PURPOSE: Beginning in the eighth week of fetal life the neuroblasts migrate from the midline to the periphery to form the gray matter of the cerebral cortex. Abnormalities of cell migration are characterized by ectopic location of neurons in the cerebral cortex. This broad group of anomalies include lissencephaly, schizencephaly, cortical dysplasia, gray matter heterotopia, and unilateral hemimegalencephaly. The purpose of this study was to correlate clinical data with anatomic data, which was evaluated by brain magnetic resonance imaging characteristics that are most useful in predicting clinical METHODS: The clinical records, EEG, and MRI findings of 20 patients with neuronal migration disorders were retrospectively reviewed. RESULTS: The 20 patients with neuronal migration disorders consisted of 11 with lissencephaly, 7 with cortical dysplasia, 2 with heterotopia, and 2 with schizencephaly. Clinically, seizure was the most common symptom in 85%, next developmental delay in 50%, and then delayed speech in 25%, motor deficit 15% in order. The main associated brain anomalies included absence of septum pellucidum in 20%, periventricular leukomalacia in 15%, and corpus callosal agenesis in 15% of Patients. Bilateral involvement of lesion in MRI was 60%, comparing to unilateral lesion in 40% of the patients. The most common involved lobes was frontoparietal region. An abnormality of EEG examination was showed in 11 cases of patients(68.7%). Patients with diffuse, bilateral lesion in MRI findings of neuronal migration disorders had significantly developmental delay than those with unilateral lesion(p=0.0007). Patients with unilateral lesion had significantly motor deficit than those with bilateral lesion(p=0.04). CONCLUSION: Seizures were the most common symptoms among neurological manifestations of neuronal migration disorders. Statistically significant correlations of delayed developement with bilateral lesion and motor deficit with unilateral lesion were found.
Brain* ; Cell Movement ; Cerebral Cortex ; Electroencephalography ; Humans ; Infant, Newborn ; Leukomalacia, Periventricular ; Lissencephaly ; Magnetic Resonance Imaging* ; Malformations of Cortical Development ; Neurologic Manifestations ; Neuronal Migration Disorders* ; Neurons* ; Retrospective Studies ; Seizures ; Septum Pellucidum

PURPOSE: recent studies have reported that the expression of Drg-1 is up-regulated by androgen. It has been suggested that Drg-1 gene be used as a molecular marker for prostate cancer therapies like PSA. To de termine the role of Drg-1 gene as a molecular marker during intermittent androgen deprivation(IAD) therapy, we investigated the expression of Drg-1 and compared it with PSA expression in human prostate cancer cell lines treated with dihydrotestosterone (DHT) continuously or intermittently. MATERIALS AND METHODS: Two prostate cancer cells having different status of androgen receptor [LNCaP (androgen dependent) and PC-3 (androgen independent)] were used in this study. To know the change in PSA and Drg-1 expression after DHT treatment the cells were cultured in steroid-free RPMI media for 24 hours. 10(-7) and 10(-8)M of DHT and 10(-7)M bicalutimide was added into the cells and then cultured for 72 hours. And we established in vitro IAD model using LNCaP cells. Northern analyses were performed to determine the expression level of both PSA and Drg-1genes. Also, western analyses were performed to determine the protein level of proliferating cellular nuclear antigen and androgen receptor. RESULTS: Transcripts of Drg-1 were detected in both LNCaP and PC-3 cells but PSA was not expressed in PC-3 cells. The expression of Drg-1gene in LNCaP cells was up-regulated by 10(-8)M of DHT like PSA gene and down-regulated by 10(-7)M bicalutamide. In the treatment of intermittent androgen deprivation, the expression pattern of Drg-1was similar to that of PSA. However, up-regulation of PSA was detected earlier than of Drg-1. CONCLUSIONS: Based on observation, Drg-1 was up-regulated by androgen and down-regulated by anti-androgen. This suggests that Drg-1gene is useful for determining the androgen independency of prostate cancer during IAD.
Cell Line ; Dihydrotestosterone ; Humans ; Prostate* ; Prostatic Neoplasms* ; Receptors, Androgen ; Up-Regulation

No abstract available.
Aged* ; Humans ; Nursing Homes* ; Nursing*

The popularity of baseball has resulted in an increase in medical attention directed toward participating players. This study focuses on injuries of the throwing arm in adolescents which occur during participation in organized youth baseball matches. History taking, physical examination and roentgenographic study of both elbows were made on 67 adolescent baseball players who visited the Department of Orthopaedic Surgery of Hanyang Vniversity Hospital from December, 1981 to January, 1982. The results obtained were as follows: 1. The average age was 12.4 years and average career playing baseball was 1 year 11 months. 2. There were 18(85.7%) overhand type pitchers. This was the most common pitching style. 3. 7(10.4%) complained of elbow pain. In all cases the pain was located on the medial aspect of the elbow. 4, On physical examination, hypertrophy of the forearm was seen in 19(28.4%), hypertrophy of the arm in 27(40.3%), limb length discrepancy in 28(41.8%), cubitus valgus deformity in 2(3.0%), and flexion contracture of the elbow in 6(9.0%) cases. 5. On roentgenographic study, cortico-trabecular hypertrophy of the humerus, and separation and fragmentation of the medial humeral epicondyle were the common findings. 6. The pain and flexion contracture of the elbow were more marked in pitchers. 7. To prevent these injuries of the elbow, the following recommandations were made by authors. Use a pitching machine in batting exercise. Restrict the number of innings pitched per game, Abolish curve ball throwing in this age group. Ensue an adequate warmup period before exercise or games. Inform parents and coaches of the possible harmful nature of excessive throwing.
Adolescent ; Arm ; Baseball ; Clinical Study ; Congenital Abnormalities ; Contracture ; Elbow ; Extremities ; Forearm ; Humans ; Humerus ; Hypertrophy ; Parents ; Physical Examination

Following is a case report of giant cell tumor of the metacarpal bone of rlght thumb treated with surgical method. The metacarpal bone except both articular surfaces was excised and replaced with an autogenous iliac bone graft. The graft bone was fixed with 3 Kirschner's wires and the thumb was immobilized with plaster cast. There has been no evidence fo recurrence during the 6 years following and function of the hand is normal.
Casts, Surgical ; Giant Cell Tumors ; Giant Cells ; Hand ; Methods ; Recurrence ; Thumb ; Transplants

In spite of numerous clinical and patho-anatomical studies made in the past, there are still different opinions concerning the machanism of low back pain. We have focused attention on the posterior structures as an alternative source of low back pain with leg radiation, so we have studied and analyzed the effect of the injection of mixture methylprednisolone acetate suspension (20-40 mg) and local anesthetic (1% procaine, 1cc) into the posterior facet joint. In this paper, the records of 41 in-patients who have chiefly compalned of low back pain wlth leg radiation and have been treated at the Departmnt of Orthopedics, Han Yang University Hospital from May, 1979 to April, 1980 were studied. The following results are recognized by observing and analyzing their chief complalnts, physical examination, x-ray findings, the effect of facet block and the follow-up studies after facet block. 1. Low back pain with sciatica was 1.9 times more common in female than male, and frequently occured In 4th to 6th decades (75.7%). 2. The abnormal findings of plain x-rays were osteophyte (35.6%), marginal sclerosis (27.1%), narrowing of disc spce (18.6%), lumbarization (11.9%), spina bifida (3.4%), and tropism (3.4%). 3. The most frequent site of abnormal posterior facet joints was at the level between 4th and 5th lumbar vertebra (42.9%), and all were on lower lumber region. 4. The range of lumbar motion was decreased in the cases of abnormal posterior facet jolnt or degenerative changes, and it was especially more decreased in the combined cases. 5. The effect of facet block was as follows; In initial assessment, 29 of 41 cases (70.7%) showed complete rellef and one month later, 16 of 29 cases (55.2%) showed continuous rolief, 4 of 18 cases (22.2%) which were followed for 3 more months showed complete relief. 6. The effect of facet block according to pain character was as follows: 20 of 26 cases (76.9%) of numbness, 5 of 6 cases (83.3%) of dull pain and 4 of 8 cases (50.0%) of radlating pain were completely relleved and a case of burning pain was partially relleved.
Burns ; Female ; Follow-Up Studies ; Humans ; Hypesthesia ; Leg ; Low Back Pain ; Male ; Methylprednisolone ; Orthopedics ; Osteophyte ; Physical Examination ; Procaine ; Sciatica ; Sclerosis ; Spinal Dysraphism ; Spine ; Tropism ; Zygapophyseal Joint

Thrombosis of one or both renal veins occurs in a variety of settings such as trauma, dehydration, extrinsic compression, nephrotic syndrome, pregnancy, oral contraceptives or invasion by tumor. Nephrotic syndrome and certain carcinomas seem to predispose to the development of renal vein thrombosis. The most common carcinoma which is associated with renal vein thrombosis is the renal cell carcinoma. But, renal vein thrombosis associated with tumor other than renal cell carcinoma is extremely rare. Our patient was diagnosed as lung and uterine cervical cancer by histologic examination. The patient complained of left flank pain. Abdominal CT scan shows the dilated left renal vein filled with hypodense material and parenchymal infarction on the left kidney. Renal arteriography shows cut-off sign on a branch of the left renal artery. Inferior venacavography revealed contrast-filling defect in the left renal vein. To our knowledge, renal vein thrombosis with lung and uterine cervical carcinoma is the first report in English literature. So, we have presented a rare case of a renal vein thrombosis in a patient with lung and uterine cervical cancer.
Angiography ; Carcinoma, Renal Cell ; Contraceptives, Oral ; Dehydration ; Flank Pain ; Humans ; Infarction ; Kidney ; Lung Neoplasms ; Lung* ; Nephrotic Syndrome ; Pregnancy ; Renal Artery ; Renal Veins* ; Thrombosis* ; Tomography, X-Ray Computed ; Uterine Cervical Neoplasms*

No abstract available.
Nasal Bone*

Human uniparental gestations such as androgenetic hydatidiform moles provide a model to evaluate the integrity of parent-specific gene expression,-i.e, genomic imprinting,- in the absence of a complementary parental genetic contribution. Several imprinted genes are characterized so far including the insulin-like growth factor-2 gene (IGF2) coding for a fetal growth factor and the Hl9 gene whose normal function is unknown but which is likely to act as an untranslated mRNA for its tumor-suppressing function. IGF2 is expressed exclusively from the paternal allele while Hl9 from the maternal allele. Such an alternate expression is quite interesting because both Hl9 and IGF2 genes are located close to each other on chromosome 11p15.5. An in situ hybridization analysis has shown strong expression of Hl9 and IGF2 alleles in nine hydatidiform moles. Especially, a prominent expression of Hl9 and IGF2 was detected in cytotrophoblast and the cellular localization was almost paralleled in Hl9 and IGF2 transcripts . Hl9 and IGF2 genes could be expressed either biallelically or monoallelically in the moles. However, IGF2 biallelic expression did not affect allele-specificity of Hl9 expression.. These results suggest that both H19 and IGF2 transcripts are expressed in the same cells and that the functional imprinting of H19 and IGF2 genes in hydatidiform moles can be controlled individually and independently of each other.
Alleles ; Chromosome Aberrations* ; Clinical Coding ; Female ; Fetal Development ; Genomic Imprinting* ; Humans* ; Hydatidiform Mole* ; In Situ Hybridization ; Insulin-Like Growth Factor II* ; Parents ; Pregnancy ; RNA, Messenger ; Trophoblasts

A case of malignant fibrous histiocytoma in the right thigh is reported together with a brief review of literature in this paper. This tumor characteristically consists of a solitary circumscribed and firm mass 5 × 5 × 4cm in dimension, which has originated in the deep soft tissues. Wide local excision has been the most common form of treatment for this lesion, after open biopsy has been performed for the diagnosis. Microscopically, there is a pattern of histiocytes and bizarre histiocytic giant cells intermingled in a fibrous stroma with fibroblasts arranged in storiform pattern. Foam cells and abnormal mitoses are also frequently found in this tumor. Local recurrence is common. Metastasis is less common but with metastasis the prognosis is poor. In this case local recurrence was noted two months after excisional biopsy but metastasis was not occurred.
Biopsy ; Diagnosis ; Fibroblasts ; Foam Cells ; Giant Cells ; Histiocytes ; Histiocytoma, Malignant Fibrous ; Mitosis ; Neoplasm Metastasis ; Prognosis ; Recurrence ; Thigh