No abstract available.
Cervix Uteri* ; Female

No abstract available.
Glomerulonephritis*

No abstract available.
Cleidocranial Dysplasia*

An open clinical trial was conducted to evaluate the efficacy and tolerability of isradipine in 30 cases (male 16, female 14 cases, average age 52.6+/-7.94) of mild to moderate essential hypertension using 1.25-2.5mg twice a day for 8 weeks of active treatment. Blood pressure was significantly reduced from 168.5+/-14.33/108.3+/-6.37mmHg, 163.7+/-9.74/105.5+/-7.1mmHg to 141.0+/-13.69/92.0+/-9.27mmHg, 138.8+/-13.46/92.3+/-11.16mmHg in sitting and standing position respectively. The extent of reduction was 27.5/16.3mmHg in sitting position and 29.9/13.2mmHg in standing position. This comprised the mean response rate in terms of reduction of DBP of 10mmHg or more being 90% and the normalization rate, deficed as DBP lowering to 90mmHg or below, being 70%. Heart rate, hematology and blood chemistry including blood sugar and lipids were not changed significantly after treatment with isradipine. No significantl side effect was observed except 2 cases of mild transient facial flushing and nausea during the treatment, so could proceed the trial without drug discontinuation in all 30 cases. The results suggest that isradipine is one of the useful and safe drugs in the treatment of mild to moderate essential hypertension.
Blood Glucose ; Blood Pressure ; Chemistry ; Female ; Flushing ; Heart Rate ; Hematology ; Humans ; Hypertension* ; Isradipine* ; Nausea

An open trial was carried out to investigate the efficacy and tolerance of isosorbide 5-mononitrate(Elantan(R)) in 30 patients diagnosed as angina pectoris at Pusan national university hospital. Drugs were given 20mg two times daily for 2 to 3 weeks and the results were assessed in terms of effects on anginal pain and untoward side effects experienced during administration of medication. Treament resulted in an overall improvement in 25 patients(83.4%), complete abolition of anginal attacks in 17 patients(56.7%) and reduction in frequency of attacks in 8 patients(26.7%). So called "Nitrated headache" was observed in 5 patients(16.6%) but improved with proceeding of administration in 3 patients. This trial indicates that isosorbide 5-mononitrate should be efficacious as well as tolerated in patients with coronary heart disease.
Angina Pectoris* ; Busan ; Coronary Disease ; Humans ; Isosorbide*

No abstract available.
Burkitt Lymphoma* ; Skin*

Weber-Christian disease is an inflammatory disease of subcutaneous fat tissue which is characterized by relapsing, febrile tender nodules and histologically lobular panniculitis. Many cases originally considered as examples of Weber-Christian disease were later found to be other diseases when lobular panniculitis was reclassified, and some authors believe that Weber-Christian disease should no longer be considered as a distinctive entity. However, there are still occasional cases which cannot be diagnosed as other specific diseases but have the characteristic manifestations of Weber-Christian disease, and they attest to the fact that Weber-Christian disease could be a distinctive disease entity. We report here a case of Weber-Christian disease in a 22-year-old female who was treated successfully with steroid pulse therapy.
Female ; Humans ; Panniculitis ; Panniculitis, Nodular Nonsuppurative* ; Subcutaneous Fat ; Young Adult

For applying the quality assurance (QA) of volumetric modulated arc therapy (VMAT) introduced in Eulji Hospital, we classify it into three different QA steps, treatment planning QA, pretreatment delivering QA, and treatment verifying QA. These steps are based on the existing intensity modulated radiation therapy (IMRT) QA that is currently used in our hospital. In each QA step, the evaluated items that are from QA program are configured and documented. In this study, QA program is not only applied to actual patient treatment, but also evaluated to establish a reference of clinical acceptance in pretreatment delivering QA. As a result, the confidence limits (CLs) in the measurements for the high-dose and low-dose regions are similar to the conventional IMRT level, and the clinical acceptance references in our hospital are determined to be 3 to 5% for the high-dose and the low-dose regions, respectively. Due to the characteristics of VMAT, evaluation of the intensity map was carried out using an ArcCheck device that was able to measure the intensity map in all directions, 360degrees. With a couple of dosimetric devices, the gamma index was evaluated and analyzed. The results were similar to the result of individual intensity maps in IMRT. Mapcheck, which is a 2-dimensional (2D) array device, was used to display the isodose distributions and gave very excellent local CL results. Thus, in our hospital, the acceptance references used in practical clinical application for the intensity maps of 360degrees directions and the coronal isodose distributions were determined to be 93% and 95%, respectively. To reduce arbitrary uncertainties and system errors, we had to evaluate the local CLs by using a phantom and to cooperate with multiple organizations to participate in this evaluation. In addition, we had to evaluate the local CLs by dividing them into different sections about the patient treatment points in practical clinics.
Humans ; Radiotherapy, Intensity-Modulated

In this study the dosimetric evaluation for a biological sample irradiated by gamma rays from Cs-137 irradiator (Gamma Irradiator, Chiyoda Technol Co., Japan) was performed for radiobiological experiment. A spherical water with a diameter of 3 cm was assumed as a biological sample. The absorbed dose were determined by the air kerma based dosimetric calculation system. The theoretical and Monte Carlo calculations (MCNPX) were performed and compared to evaluate measured air kerma and determined absorbed dose respectively. As a result of comparison with theoretical calculation, the measured air kerma was in good agreement within 3.1% at the distance of 100 and 200 cm from the source. In comparison with Monte Carlo results the determined absorbed dose along the central axis was in good agreement within 1.9% and 3.7% at 100 cm and 200 cm respectively. Although the preliminary results were obtained in this study these results were used as a basis of dosimetric evaluation for radiobiological experiment. Extended study will be performed to evaluate the dose in various conditions of biological samples.
Axis, Cervical Vertebra ; Gamma Rays ; Water

OBJECTIVE: Previous epidemiological studies have suggested that hyperfibrinogenemia is an independent risk factor for cerebrovascular atherosclerosis. Fibrinogen is a key factor in the coagulation cascade, and it is suggested to play in a significant role in atherosclerosis. However, there have been relatively few studies regarding the relationship between the level of fibrinogen and prognostic influence in stroke subtypes. We prospectively evaluated that whether plasma fibrinogen levels in the acute stage were related to clinical outcome in each subtype of acute ischemic stroke. METHODS: Acute ischemic stroke was classified by the Trial of Org 10172 in the Acute Stroke Treatment (TOAST) classification. Large atrery atherosclerosis (LAA), and small vessel occlusion (SVO) were included in the classification; cardioembolic (CE) occlusion, and other causes and undetermined causes were excluded from the classficiation. The level of fibrinogen was determined within 24 hours after stroke. Stroke severity and outcome was assessed using the National Institutes of Health Stroke Scale (NIHSS) score at admission (baseline) and follow-up (4 weeks later). The NIHSS changes were compared from baseline to follow-up. Patients with NIHSS changes were divided into two groups: the good group (NIHSS had improved) and poor group (NIHSS had no change or had worsened). Patients were placed into two groups based on the plasma fibrinogen level: the normal group (plasma fibrinogen level of 200~400mg/dl) and high group (plasma fibrinogen level >400mg/dl). The level of plasma fibrinogen and changes of NIHSS were analyzed by the Chi-squared tests and multiple logistic regression. RESULTS: A total of 619 patients with acute ischemic stroke were studied. Among the 619 patients, there were 251 patients with LAA and 229 patients with SVO. Multiple logistic regression analysis indicated that a high level of plasma fibrinogen (p < 0.001), a high level of C-reactive protein (p < 0.001) and the presence of diabetes mellitus (p = 0.026) were related to poor prognosis with acute stage ischemic stroke. Partial correlation analysis showed that the plasma fibrinogen levels were related to LAA (p = 0.05) and NIHSS at admission (p = 0.007) in patients with a high plasma fibrinogen level. However, there was no statistical significance of ischemic stroke subtype and NIHSS in patients with a normal level of plasma fibrinogen. CONCLUSION: An elevated level of plasma fibrinogen seemed to be associated with LAA in acute ischemic stroke and with a poor clinical outcome.
Atherosclerosis ; C-Reactive Protein ; Classification ; Diabetes Mellitus ; Epidemiologic Studies ; Fibrinogen* ; Follow-Up Studies ; Humans ; Logistic Models ; National Institutes of Health (U.S.) ; Plasma* ; Prognosis ; Prospective Studies ; Risk Factors ; Stroke*