Mutation of the p53 gene frequently results in overexpression of the p53 protein and loss of its tumor-suppressing properties. The overexpression of the p53 gene could be an indicator of rapid proliferation, poor differentiation, advanced stages, or poor prognosis. The prognostic value of the overexpression of the p53 gene in colorectal carcinoma is equivocal. The presence of DNA aneuploidy has been described as a powerful adverse prognostic indicator in relation to survival. To investigate the prognostic significance of p53 expression, and the relationship with DNA ploidy, 92 cases of colorectal carcinomas were analyzed. The overexpression of p53 gene product was present in 50(54.4%) of 92 cases. p53 expression only correlated with recurrence or metastasis during the follow-up periods (p=0.045). DNA aneuploidy was observed in 32(39.1%) of 82 cases. DNA ploidy was strongly associated with lymph node invasion(p=0.005), Dukes' stage(p=0.003), TNM classification (p=0.003), and recurrence or metastasis during the follow-up periods (p=0.045). The frequency of DNA aneuploidy was higher in the p53-positive colorectal carcinomas(58.3%) than in the p53-negative colorectal carcinomas (21.6%) (p=0.003). p53-positive colorectal carcinomas had a higher rate of cell proliferation than p53-negative cases(p<0.001). These results suggest that checking the p53 expression and DNA ploidy could be useful prognostic indicators of colorectal carcinoma.
Neoplasm Metastasis ; Genes, p53

No abstract available.
Varicose Veins

Clinical observation was made on the 16 patients of penile carcinoma admitted to the Department of Urology, Seoul National University Hospital during the period from September, 1967 to August, 1976 and the following results were obtained. 1. The incidence of penile carcinoma was 0.5% of total inpatients of urologic department and 3.5% of male genitourinary tumors. 2. Age distribution was between 29 and 78, snowing highest incidence at 50-59 years. 3. Clinical findings were; mass 77%, discharge 28%, ulcer 25%, bleeding 13%, and inguinal lymphadenopathy 50%. 4. The average duration of the symptoms on admission to hospital was 10 months with the highest incidence in 1 to 6 months. 5. The locations of the tumors were; preputial cavity 87%, confined to glans 6%, penile shaft involved 6%. 6. Treatments were made with partial amputation in 50%, partial amputation with inguinal lymphadenectomy in 37%, and biopsy in 13%.
Age Distribution ; Amputation ; Biopsy ; Hemorrhage ; Humans ; Incidence ; Inpatients ; Lymph Node Excision ; Lymphatic Diseases ; Male ; Penis* ; Seoul ; Snow ; Ulcer ; Urology

No abstract available.
Epilepsies, Partial* ; Paragonimiasis*

OBJECTIVE: To investigate the response of hyperplastic endometrium to Medroxyprogesterone acetate according to the histologic types such as simple typical, complex typical and atypical hyperplasia. METHODS: A total of 79 patients with histologically proved endometrial hyperplasia were enrolled into this prospective study between March 1996 and May 1998. Patients without atypia were placed on a regimen of cyclic therapy with 10mg MPA orally, each day for 14days per month for 3 months. In the cases in which hyperplasia did not regress , MPA was increased to 20mg. Patients with atypical hyperplasia received continuous MPA therapy, 20mg orally each day for 3 month. All patients were followed up for a minimum of 3 months and a maximum of 1 year(mean 7 months). RESULTS: In patients with simple typical hyperplasia, 45 patients(80.4%) had regression, 11 patients(19.6%) had persistence and none had progression. In patients with complex typical hyperplasia, 10 patients(83.3%) had regression, 2 patients(16.7%) had persistence and none had progression. But, in patients with atypical hyperplasia 5 patients(45.4%) had regression, 4 patients(36.4%) had persistence and 2(18.2%) patients had well differentiated endometrial adenocarcinoma. There was no recurrence during the follow up. CONCLUSION: This data suggest that most women with typical hyperplasia respond to progestin therapy, but there is high failure rate of response to progestin therapy and risk of endometrial cancer in patients with atypical hyperplasia. If the young patient desires to preserve her fertility, then progestin therapy may be considered as primary treatment in patients with atypical hyperplasia. But older patients in whom fertility is not an issue, hysterectomy should be selected as treatment of choice for atypical lesion.
Adenocarcinoma ; Endometrial Hyperplasia* ; Endometrial Neoplasms ; Endometrium ; Female ; Fertility ; Follow-Up Studies ; Humans ; Hyperplasia ; Hysterectomy ; Medroxyprogesterone Acetate ; Medroxyprogesterone* ; Prospective Studies ; Recurrence

We have encountered many patients with dermatologic problems caused by animals, but there are not so many systematized literature about them in Korea. Since these causative animals are different from foreign animals in their distribution and habitat, there have been much difficulties in making diagnosis and in studying them based on foreign literature. We have undertaken this study to get the basic material for the possible causative animals in Korea by comparing with foreign literature, searching out the books of zoological claasification, and through personal contacts. One hundred and five species are found to be identical with the species reported in foreign literature, but 324 species are not, although they could be placed in the same genus.
Animals* ; Diagnosis ; Ecosystem ; Epidemiologic Studies* ; Humans ; Korea* ; Skin Diseases* ; Skin*

PURPOSE: To evaluate the fundus findings of diabetes mellitus (DM) patients who visited the department of ophthalmology for the first time and to emphasize the importance of early diagnosis and treatment of diabetic retinopathy (DR). METHODS: After 84 DM patients were asked to respond to the questionaire regarding previous medical histories and underwent the general ophthalmological examination, their fundus findings were analyzed and the incidence rates of DR were evaluated according to the prevalence period of DM and the compliance with treatment for DM as well. RESULTS: Motivations of visit to ophthalmology were impairment of visual acuity (46.4%) and requests by medical doctors (35.7%), examinations for other ophthalmologic diseases (13.1%), and mass media (1.2%) in the order. Diagnosis rate of DR in 84 patients who visited our department for the first time was 52.4% and among these, occupying rates of non-proliferative DR and proliferative DR were 47.7% and 52.3% respectively. Incidence rates of DR according to prevalence period of DM were 26.9% in 5 and 10 15 years. Incidence rates of DR according to compliance with treatment for DM were 45%, 50% in regularly and irregularly treated patients respectively. CONCLUSIONS: These results showed that high percentage of DM patients did not take the ophthalmological examination and treatment even though they already had various degree of DR. In these patients, the longer prevalence period of DM, the higher incidence rate of DR, and irregularly treated patients tended to increase the incidence rate of DR compared to regularly treated patients. Thus we emphasize that active public information is required urgently on the importance of early diagnosis and treatment of DR to primary medical doctors to care DM patients as well as DM patients themselves.
Compliance ; Diabetes Mellitus* ; Diabetic Retinopathy ; Diagnosis ; Early Diagnosis ; Humans ; Incidence ; Mass Media ; Ophthalmology ; Prevalence ; Visual Acuity

OBJECTIVE: This study was designed to evaluate the efficiency of tumor markers level for early diagnosis of ovarian malignancy and for differentiation between benign and malignant ovarian tumors. MATERIALS AND METHODS: We determined preoperative serum tumor markers level in patients who were going to have an operation due to ovarian tumor in OB & GY Dept. of Chonnam University Hospital from April 1993 to September 1999. RESULTS: 1) The average values of serum tumor markers in patients with malingnant ovarian tumors were statistically higher than those of benign ovarian tumors. among malignant ovarian tumors, positive rate of all serum tumor markers was highest in epithelial ovarian carcinoma group. and among ovarian tumor markers, and positive rate of CA 125 was highest in epithelial ovarian carcinoma. 2) Dermoid cyst and endometioma were correlated to CA 19-9, CA 125 levels respectively. for malignant tumors, mucinous ovarian adenocarcinoma and non-mucinous ovarian adenocarcinoma were CA 19-9, CA 125 levels respectively. 3) Among ovarian tumor markers, CA 125 was the most in sensitivity and CA 72-4 was the most in specificity and diagnostic efficiency. 4) For postmenopausal women with ovarian tumors, elevated levels of at least one of the 4 tumor markers were present in the serum in 85.7% of the women who developed cancer, 62.5% of women with borderline, 27.8% of women with benign ovarian tumors. Conclusion; It is suggested that determination of serum tumor markers in patient suspected of ovarian tumor may be helpful to clinician for early diagnosis, differentiation between malignant and benign ovarian tumors.
Adenocarcinoma ; Dermoid Cyst ; Early Diagnosis ; Female ; Humans ; Jeollanam-do ; Mucins ; Sensitivity and Specificity ; Biomarkers, Tumor*

No abstract available.
Hepatitis, Chronic* ; Interferon-alpha* ; Killer Cells, Natural* ; Prednisolone*

Pearly penile papules are small, smooth, dome-shaped, grayish to skin-colored papules, that are arranged in one or several rows. These are commonly located circumferentially on the corona and sulcus of the glans penis. A 36-year-old male patient had had asymptomatic numerous pearly smooth 1 * 1mm -sized dome-shaped papules for several months. A Histopathological examination revealed an increased number of fibroblasts on the papillary dermis, vascular proliferation and a mild lymphocytic infiltration. We diagnosed the condition as pearly penile papules. No treatment other than reassurance was given. We report, herein, a case of pearly penile papules.
Adult ; Dermis ; Fibroblasts ; Humans ; Male ; Penis