PURPOSE: The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-1beta(IL-1beta), cyclooxygenase2 (COX-2) and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse. MATERIAL AND METHODS: Mice of this study were devided into 4 groups: Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply). RESULTS: Hyaluronic group showed less expressions of IL-1beta, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope. Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope. CONCLUSION: It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.
Animals ; Cytokines ; Dinoprostone ; Ear ; Edema ; Electrons ; Gene Expression ; Hyaluronic Acid ; Inflammation ; Light ; Mice ; RNA, Messenger

Animals ; Dinitrofluorobenzene ; Ear ; Electrons ; Erbium ; Gene Expression ; Humans ; Inflammation ; Interleukin-1beta ; Laser Therapy ; Lymphocytes ; Male ; Mice ; Skin ; Tumor Necrosis Factor-alpha

Chin ; Contracts ; Genioplasty ; Humans ; Mandible ; Osteotomy ; Tissue Donors ; Transplantation, Homologous ; Transplants