No abstract available.
Thyroidectomy*

PURPOSE: This study was to investigate factors influencing the Framingham risk score-Coronary heart disease (FRS-CHD) according to gender and body mass index (BMI) of adults who participated in the 5th Korea National Health and Nutrition Examination Survey (KNHANES V-3). METHODS: This study used a cross-sectional design with secondary analysis with KNHANES V-3. The FRS-CHD scores were measured with ages, sex, blood pressure, cholesterol, high density lipoprotein, smoking, and diabetes mellitus. With demographic characteristics, family history of ischemic heart disease, types (intensity) and days of physical activities, perceived stress, drinking, menopause (in female), and BMI scores were measured. The data were analyzed with descriptive statistics, Pearson's correlation coefficients, and multiple regressions. RESULTS: FRS-CHD was significantly associated with types (intensity) and days of physical activities, educational level, occupation, and marital status, explaining 19.1~76.8% of the variance in men. FRS-CHD was significantly associated with types (intensity) and days of physical activities, menopause, and education level, explaining 55.0~59.5% of the variance in women. CONCLUSION: Factors influencing FRS-CHD were significantly different according to gender and BMI. To reduce the risk of coronary artery disease, it is necessary to develop gender-specific physical activity programs according to BMI.
Adult ; Blood Pressure ; Body Mass Index ; Cholesterol ; Coronary Artery Disease ; Coronary Disease ; Diabetes Mellitus ; Drinking ; Education ; Family Characteristics ; Female ; Heart Diseases* ; Humans ; Korea ; Lipoproteins ; Male ; Marital Status ; Menopause ; Motor Activity ; Myocardial Ischemia ; Nutrition Surveys ; Occupations ; Smoke ; Smoking

Lipoid pneumonia is chronic, interstitial, proliferative inflammation resulting from aspiration of lipoid material. Mineral oil is a hydrocarbon that physicians often use to treat chronic constipation in children and adults. Mineral oil may not elicit a normal protective cough reflex and may impair mucociliary transport. We experienced a case of exogenous lipoid pneumonia caused by aspiration of mineral oil given as a laxatives confirmed by fiberoptic bronchoscopy with bronchoalveolar lavage and bronchial biopsy in a 9-month-old boy with chronic cough and radiologic evidence of parenchymal lung disease.We reported this case with a brief review of related literatures.
Adult ; Biopsy ; Bronchoalveolar Lavage ; Bronchoscopy ; Child ; Constipation ; Cough ; Humans ; Infant ; Inflammation ; Laxatives* ; Lung ; Male ; Mineral Oil ; Mucociliary Clearance ; Pneumonia* ; Reflex

No abstract available.
Ultrasonography*

This study was performed to evaluate the influence of clonidine pretreatment on the car- diovascular toxic effects of bupivacaine overdose induced by constant intravenous infusion. Thirty male rabbits were used for this study and they were divided into saline pretreatment group(15) and clonidine-pretreatment group(15). The changes of mean arterial pressure, heart rate and electrocardiogram by the bupivacaine-induced toxic effect during intravenous infusion of bupivacaine were observed. The results were as follows; 1. Mean arterial pressure was significantly decreased in clonidine-premedicated group compared with control group (P<0.01) before infusion of bupivacaine, but the times occuring 25% and 50% decrease of mean arterial pressure were significantly prolonged in clonidine group compared with control group (P <0.001 ). 2. Heart rate was significantly decreased in clonidine group compared with control group (P<0.01) before infusion of bupivacaine, but the times occuring 25% and 50% decrease of heart rate were significantly prolonged in clonidine group compared with control group (P< 0.001). 3. The times occuring the first QRS modification and first dysrhythmia and the final systole were significantly prolonged in clonidine group compared with control group (P < 0.001). In conclusion, clonidine given prophylactically delays the cardiotoxicity caused by bupivacaine overdose snd does not accentuate the subsequent hypotension.
Arterial Pressure ; Bupivacaine* ; Clonidine* ; Electrocardiography ; Heart Rate ; Humans ; Hypotension ; Infusions, Intravenous ; Male ; Rabbits* ; Systole

No abstract available.
Abscess* ; Animals ; Immunoglobulin G* ; Mice*

Deep cervical space abscess may cause life-threatening complications despite the advent of antibiotics, so early detection and localization of the abscess are essential for management decision. To evaluate the efficacy of utilizing CT scanning in deep cervical space abscess, we retrospectively revieweed CT of 17 patients confirmed by surgery. CT was found tobe very accurate in defining the presence, location, and extent of the abscess along with the demonstration of life-threatening complications such as airway compression and mediastinal extension. In conclusion, CT can play and essential role in guiding surgical approach to deep cervical space abscess.
Abscess* ; Anti-Bacterial Agents ; Humans ; Retrospective Studies ; Tomography, X-Ray Computed

Pediatric infection with Helicobacter pylori may occur early in childhood and persist lifelong. Global pediatric clinical studies have reported a decreasing tendency in the overall rate of H. pylori eradication. In pediatric patients with H. pylori infection, pediatric patients with peptic ulcer, and the first-degree relatives of patients with a history of gastric cancer, it is commonly recommended that H. pylori strains be eradicated. Antibiotic drug resistance to H. pylori, which has been reported to vary widely between geographic regions, is mainly associated with treatment failure in these patients. It is therefore imperative that the antibiotic resistance rates of H. pylori in children and adolescents be meticulously monitored across countries and throughout geographic regions. This paper particularly focuses on the antibiotic drug resistance of H. pylori and the thearpy of pediatric H. pylori infection cases.
Adolescent ; Anti-Bacterial Agents* ; Child* ; Drug Resistance ; Drug Resistance, Microbial ; Helicobacter pylori* ; Helicobacter* ; Humans ; Peptic Ulcer ; Stomach Neoplasms ; Treatment Failure

The present study evaluated the effect of various dosages of soybean isoflavone extract on body weight changes, glucose tolerance and liver function in streptozotocin-induced diabetic rats. One group of normal rats (normal control) was fed an AIN-76-based experimental diet and four groups of diabetic rats were fed the same diet supplemented with four different levels of soybean isoflavone extract for seven weeks. The daily dosages of pure isoflavone for four diabetic groups were set to be 0 mg (diabetic control), 0.5 mg (ISO-I), 3.0 mg (ISO-II) and 30.0 mg (ISO-III) per kilogram of body weight, respectively. The daily consumption of isoflavone at the level of 3.0mg per kilogram of body weight resulted in the suppression of body weight loss and increased the survival rate of diabetic animals one and half times compared to that of the diabetic control group. Blood glucose levels in a fasting state and after the oral administration of glucose were significantly lower in the ISO-II group during the oral glucose tolerance test. The ISO-II group showed a tendency to elongate the gastrointestinal transit time. The activity of serum aminotransferases, indicator of liver function, was not negatively affected by any intake level of isoflavone. The present study demonstrated that the soybean isoflavone extract may be beneficial to diabetic animals by improving their glucose tolerance and suppressing weight loss without incurring hepatotoxicity at the daily dosage of 3.0 mg per kg of body weight.
Administration, Oral ; Animals ; Blood Glucose ; Body Weight ; Body Weight Changes ; Diet ; Fasting ; Gastrointestinal Transit ; Glucose Tolerance Test ; Glucose* ; Liver ; Rats* ; Soybeans* ; Streptozocin ; Survival Rate* ; Transaminases ; Weight Loss

BACKGROUND: The concept of "neovascularization", which was first applied to describe the pathogenesis of diseases such as diabetic retinopathy or rheumatoid arthritis, has been extended to other fields of study such as myocardial ischemia and tumorigenesis. Endothelial progenitor cells (EPCs), play a critical role in neovascularization and have been reported to also be capable of colonizing vascular grafts. In this study, EPCs were isolated from cord blood, peripheral blood and bone marrow, and then cultured. Various cytokines, such as vascular endothelial growth factor(VEGF), Insulin growth factor(IGF), endothelial growth factor(EGF) fibroblast growth factor-basic(FGF-b), stem cell factor(SCF), flt3-ligand(FL), and thrombopoietin(TPO) were added to the cultures and observed for their effects on endothelial cells for their potential use in antineoplastic therapy or treatment of regional ischemia. METHODS: The mononuclear cells (MNCs) were isolated from cord blood, peripheral blood buffy coat, and bone marrow. They were collected from healthy donors using Ficoll-Hypaque. CD34+ cells were isolated by MACS system. To evaluate the effect of various cytokines, purified CD34+ cells were cultured under conditions of various cytokine combinations including SCF, Fl, TPO, VEGF, EGF, IGF, and FGF-b. After four weeks of culture, umbilical cord blood and bone-marrow derived adherent cells were analyzed for endothelial markers by immunohistochemical stain. RESULTS: Cultured adherent cells expressed the endothelial specific markers, such as KDR, CD34, CD31, CD62E, and CD cadherin but did not express vWF antigen. Typical morphology of endothelial cells was observed, such as the cord-like structure and cobblestone appearance during the culture period, which suggested that the adherent cells were consistent with endothelial cells. CONCLUSION: We described the experimental conditions in which endothelial progenitors were differentiated from CD34+ cells isolated from three hematopoietic stem cell sources: bone marrow, peripheral blood and cord blood.
Arthritis, Rheumatoid ; Blood Buffy Coat ; Bone Marrow ; Bone Marrow Cells ; Carcinogenesis ; Colon ; Cytokines ; Diabetic Retinopathy ; Endothelial Cells ; Epidermal Growth Factor ; Fetal Blood ; Fibroblasts ; Hematopoietic Stem Cells* ; Humans ; Insulin ; Ischemia ; Myocardial Ischemia ; Stem Cells* ; Tissue Donors ; Transplants ; Vascular Endothelial Growth Factor A