We evaluated the characteristics of HMB-45 monoclonal antibody(MoAb) and compared it with a polyclonal anti-S-100 antibody in immunohistochemical staining of 22 primary melanomas of the skin ; 13 acral lentiginous melanomas(ALM), 3 superficial spreading melanomas(SSM), 4 lentigo maligna melanomas(LMM), 3 nodular melanomas(NMM). All speimens were formalin-fixed and paraffin-embedded, and were studied with the avidin-biotin-peroxidase complex technique. The results can be summarized as follows : l. In all tissue specimens, all or some of the melanoma cells in the dermis reacted with HMB-45 MoAb and anti-S-100 protein. 2. HMB-45 MoAb is more sensitive in detecting malignant melanoma cell heterogeneity t,han anti-S-100 protein. 3. Melanoma cells within the epidermis in 6 of 12 ALMs and 3 of 4 LMMs did not react with anti-S-100 antibody, whereas most melanoma cells within epidermis of 12 ALMs and 4 LMMs reacted with HMB-45 monoclonal antibody. These results indicated that immunohistochemical staining with HMB-45 MoAb and anti-S-100 protein is very useful in the study of biologic behavior of malignant, melanoma.
Dermis ; Epidermis ; Hutchinson's Melanotic Freckle ; Melanoma* ; Population Characteristics ; Skin

Treatments of tibia shaft fracture are closed reduction followed by cast immobilization, external fixation, intramedullary nailing and internal fixation with plate and screws. Among these, intramedullary nailing is commonly used method today. The tibia nailing has high rate of union, but malunion, infection, the joint stiffness and anterior knee pain develops frequently. We reviewed the clinical and radiological result of anterior knee pain retrospectively after tibia nailing. The result were as follows: l. Age distribution of tibia shaft fracture was 17 to 76, and mean age was 40 male patients were 35 and female 13. 2. The open fractures were 17 and the closed fractures were 34. 3. The causes of' tibia shaft fracture were traffic accidents(30cases), fall down injuries(6 cases), slip down injuries(1 1 cases) and other injuries(4 cases) Among the these, 19 cases were cornbined with other fractures or neuri.isurgical injuries. 4. The incision methods were recorded as follows: parapatella tendon incision were 9 cases, patella splitting incision were 25 cases and unrecorded were 17cases. 5. According to the radiological analysis, the average nail plateau distance was 10.3mm and the extent of nail protrusion beyond the anterior cortex was -1.73mm. Among these, protrusion of proximal targeting screws were 8 cases. 6. Insertion of nail through the patella tendon was associated with a hipher incidence of knee pain compared to paratendon site of insertion. The extent of nail protrusion were related to anterior knee pain after tibia intramedullary nailing.
Age Distribution ; Female ; Fracture Fixation, Intramedullary* ; Fractures, Closed ; Fractures, Open ; Humans ; Immobilization ; Incidence ; Joints ; Knee* ; Male ; Patella ; Patellar Ligament ; Retrospective Studies ; Tendons ; Tibia*

No abstract available.
Gestational Age* ; Intracranial Hemorrhages*

No abstract available.
Thanatophoric Dysplasia*

No abstract available.
Animals ; Chitosan* ; Eating* ; Mice*

No abstract available.
Animals ; Chitosan* ; Rats* ; Water*

Adenocarcinoma of the bladder is a rare tumor. It's incidence figures in the ranges of 0.5 to 2.0 percent of all epithelial bladder neoplasms. Adenocarcinoma of the bladder occurs more frequently in areas which schistosomiasis is endemic and is the most common malignant tumor arising in the exstrophic bladder or urachus. Primary adenocarcinoma of the bladder must be carefully differentiated from the adenocarcinomas that originate within the urachus, prostate, seminal vesicle, breast, gastrointestinal tract or other organs. This report describes a 43 years old male who was diagnosed as an infiltrative adenocarcinoma of the bladder by the preoperative evaluation and transurethral resection of bladder and was confirmed by the pathologic examination following pelvic exenteration as the primary adenocarcinoma or the bladder extended to the prostate and rectum and was followed by chemotherapy without evidence of metastasis.
Adenocarcinoma* ; Adult ; Breast ; Drug Therapy ; Gastrointestinal Tract ; Humans ; Incidence ; Male ; Neoplasm Metastasis ; Pelvic Exenteration* ; Prostate ; Rectum ; Schistosomiasis ; Seminal Vesicles ; Urachus ; Urinary Bladder Neoplasms ; Urinary Bladder*

OBJECTIVE: To report the pregnancy which was made by in vitro fertilization using recombinant follicle stimulating hormone and gonadotropin releasing hormone antagonist. MATERIAL AND METHOD: Case report. RESULTS: Six oocytes were retrieved and all were fertilized by intracytoplasmic sperm injection. Six embryos were transferred and the pregnancy was confirmed. CONCLUSION: It is envisaged that the availability of recombinant gonadotropins and gonadotropin releasing hormone antagonists will ultimately lead to shorter, cheaper and safer treatments, using reduced dosages.
Pregnancy ; Female ; Humans

PURPOSE: To evaluate the effectiveness of intreaepithelial photorefractive keratectomy (IE-PRK) for the treatment of myopic regression after laser in situ keratomileusis (LASIK) METHODS: 38 eyes of 22 patients who had previous LASIK for myopia were selected and retreated with IE-PRK, in which a photoablation was performed directly in the epithelium without damage to Bowman's layer. All eyes were elapsed at least 6 months after the LASIK. Follow-up was up to 6 months and within +/-0.50 of emmetropia on 6 months after surgery was considered as a success. RESULTS: Before IE-PRK, the eyes regressed to a mean of .1.26+/-0.45 D spherical equivalent (SE). The mean SE at 1 week after IE-PRK was .0.44+/-0.88 D, 1 month was .0.59+/-0.45 D, 3 month was .0.63+/-0.41, 6 month was .0.62+/-0.43 (p<0.05). 23 of the 38 eyes (60.5%) had refraction within +/-0.50 and were considered as successfully treated. Preoperative mean best corrected visual acuity (BCVA) was 0.33+/-0.18 (Snellen equivalent) and final mean BCVA was 0.77+/-0.99 (p<0.01). There were no significant complications of corneal flap. CONCLUSIONS: The results of this study indicate that intraepithelial photorefractive keratectomy appears to be a safe means for treating patients for regression after LASIK procedure. But success rate was not so good as the enhancement. Controlled studies with larger population will be necessary to evaluate the accuracy of the method more correctly.
Emmetropia ; Epithelium ; Follow-Up Studies ; Humans ; Keratomileusis, Laser In Situ* ; Myopia ; Photorefractive Keratectomy* ; Visual Acuity

Recently we experienced two cases of cerebral cavernous hemangioma in children at Pediatric Department of Yonsei Medical School. We are reporting these two cases with literature review.
Child* ; Hemangioma, Cavernous, Central Nervous System* ; Humans ; Schools, Medical