Ultraviolet radiation of skin leads to a systemic alteratior tkat inhibits the normal pattern of immunologic tumor rejection., suppresses the contact hypersemisivity and transiently alters the morphology and the surface marker characteristics of Langerhans cells. Moreover, Ultraviolet radiation elaborates the ETAF, neuropeptides, proteins, and urocaicacid which may alter immunologic responses. But no other study about the effects of UVB irradiation on the systemic immunologic functions of the macrophages of internal organs was reported. The macrophages of the reticuloendothelial system (RES) play a central role in cell-mediated immunity, because they are involved both in the initiation of responses as antigen-presenting, cells, and in the effector phase as inflammatory, tumoricidal and microbicidal cells. The present study was intended to investigate the effects of UVB irradiation on the immunologic functions of mouse peritoneal macrophages. Normal 6-8-week-old BALB/c mice were exposed at the dose rate of 20mJ/cm and 40mJ/cm of UVB per day, 5 days per weeks for 2 weeks, 4 weeks and 8 weeks. Then the peritoneal macrophages were obtained from the mice and the changes of cell count, chemotactic index, phagocytic index, NBT reduction rate and superoxide (0) production were examined. The results were as follows : 1)the number of mouse peritoneal macrophages was decreased by UVB radiation, 2) the chemotactic index of mouse peritoneal macrophage was not altered by UVB radiation, 3) phagocytic activity of mouse pertoneal macrophage was significsntly decreased by UBV radiation, 4) NBT reduction rate in mouse aeritoneal macrophage after UVB radiation was sinificanily decreased in all experimental group, and 5) Superoxide (0) production in mouse peritoneal macrophage after UVB radiation was decreased in all experimental groups.
Animals ; Cell Count ; Immunity, Cellular ; Langerhans Cells ; Macrophages ; Macrophages, Peritoneal* ; Mice* ; Mononuclear Phagocyte System ; Neuropeptides ; Skin ; Superoxides

Hand injuries in the industries have been steadily increasing in this country in recent years. All structures are damaged when a hand is caught in punch presses, gears or under falling objects. Irreversible loss of blood supply to the part is only real indication for primary amputation. Statistical observations were carried out on 240 patients of hand injuries who were treated at the Deparement of Orthopedic Surgery, College of Medicine, Hanyang University from May, 1972 to April, 1977 and following results were obtained. 1. The peak incidence was in the age group from 11 to 20 years in 83 cases(38.4%) and of the 226 patients, 204(85.0%) were male and 36(15.0%) were female. 2. In general, the incidence of hand injuries per year was annually increased and was much more occurred on April than other months of year. 3. The injured ratio of both hands was almost equal and main causes of hand injury were industrial accident (72.1%), traffic accident(12.9%) and electric accident(6.3%). 4 Most of hand injured patients(81.7%) arrived at our hospital within 6 hours after accidents 5. Of 240 injuries, 78(32.5%) were crushing injury with open comminuted fracture, 39(16.2%) were open fracture and 30(12.5%) were closed fracture. 6. Of injured fingers, 126(51.2%) were mondigit and the remained were polydigits. 7. The most frequency of monodigit injury was index finger(32.5%) and of polydigits injury was middle finger(28.2%) 8. In mondigit amputation, index finger were generally amputated at metacarpo-phalangeal joint and middle finger at proximal phalangeal level. 9. Of 457 injuries with facture, 213(46.6%) were treated by debridement and primary suture, and 94 (20.6%) by debridement and open reduction with Kirschner wire fixation. 10. Of 240 patients, 46 cases(19.2%) were infected and the main causative organisms were pseudomonas aeruginosa (41.3%), Staphylococcus aureus(17.3%) and Alkaligenus fecalis(10.9%).
Accidental Falls ; Accidents, Occupational ; Amputation ; Clinical Study ; Debridement ; Female ; Fingers ; Fractures, Closed ; Fractures, Comminuted ; Fractures, Open ; Hand Injuries ; Hand ; Humans ; Incidence ; Joints ; Male ; Orthopedics ; Pseudomonas aeruginosa ; Staphylococcus ; Sutures

Dermabrasion involves the removal of the epidermis and the upper dermis by means of a motor-driven rotary abrasive instrument or a brush using ethyl chloride or dichlorotetrafluoroethane(Freon) as the evaporative refrigerant-anesthetic. Kurtin(1952) developed this refrigeration-abrasion method and named it skin planing. The technique of skin planing was introduced to Korea in early 1960s and it was extensively used for corrective surgery of scar induced by small pox until early 1970s. The indication for dermabrasion includes correction of scars, prophylaxis and correction of aging of the skin, removal of congenital nevoid anomalies, malignant and benign skin tumors, tattoos and others. The authors dermabased the cutaneous lesions of xeroderma pigmentosum, angiofibroma (adenoma sebaseum), nevus sebaceus of Jadassohn, epidermal verrucous nevus and linear porokeratosis, using Stryker' pneumatic powered dermabrader, with successful results. The technique of dermabrasion and the literature were briefly reviewed.
Aging ; Angiofibroma ; Cicatrix ; Dermabrasion* ; Dermis ; Epidermis ; Ethyl Chloride ; Korea ; Nevus, Sebaceous of Jadassohn ; Porokeratosis ; Skin ; Skin Diseases* ; Xeroderma Pigmentosum

BACKGROUND: Previous studies have shown that in vitro exposure to ultraviolet B(UVB) radiation resulted in a dose-dependent inhibition of natural killer activity(NK activity) of normal human peripheral blood mononuclear cella(PBMC), and that in vivo exposure to snlight also induced NK activity suppression. The precise meehanism of the UV-regulation on the riat iral killer system(NK system) is not established. Objective & METHOD: The purpose of this study is to examine whether the addition of interleukin-2(IL-2) and/or free oxygen radical scavengers, superoxide dismutas(SOD) or sodium azide(SA), is effective in reducing the UVJ3-induced suppression of NK activity of FBMC. RESULTS: The results are as follows 1. The suppressive effect of UVB radiat,ion on NK activity could successfully be prevented in the presence of SOD(100 and 1,000U/ml) during the radiation. 2. SA( LO and 10 M/ml) did not prevent the suppression of NK activity. 3. IL-2(100U/ml) markedly enhanced the NK activity of nonirradiated PBMC, but had no effect on irradiated PBMC. 4. Combination treatment with both IL-2 and free radical scavengers on UVB-irradiated PBMC resulted in no additive or synergistic effect on the prevention of the suppression of NK activity compared with a single treatment with either IL-2 or free radical scavengers. CONCLUSION: In the presserit study, we found that SOD providec a protective effect on NK activity during the UVB radiation and we suggest that superoxide anion(O ) might play a major role in the UV-regulatory mechanisms of the NK system.
Free Radical Scavengers ; Humans* ; Interleukin-2* ; Oxygen ; Sodium ; Superoxides

No abstract available.
Child* ; Humans

No abstract available.
Aged* ; Humans ; Nursing Homes* ; Nursing*

No abstract available.
Nephrotic Syndrome* ; T-Lymphocyte Subsets* ; T-Lymphocytes*

In open wounds of the hand that have exposed bone or tendons, management may be difficult. Compared with conventional cutaneous pedicle flaps, the fascial radial flap transfer has several advantages : (1) one operation is required by one operating team reliably and easy to perform, (2) the appearance is not bulky, (3) the donor area is closed primarily, and (4) the hand is free for early motion of the shoulder and the elbow. One potential disadvantage is the permanent loss of the contribution of the radial artery to the circulation of the hand. One case of the fascial radial flap transfer was performed at the Department of Orthopaedic Surgery of Hanyang University Hospital, and satisfactory result was obtained.
Elbow ; Hand ; Humans ; Radial Artery ; Shoulder ; Tendons ; Tissue Donors ; Wounds and Injuries

Ossification of the anterior longitudinal ligament of the spine was first reported by Dr. Forestier and Dr.Rotes in 1950. However, in no other countries but Japan there have been reports on the ossification of the posterior longitudinal ligament of the spine which was first reported by Tsukimoto in 1960. About 45% of ossification of the posterior longitudinal ligament of the spine have a combination of ossification of the anterior longitudinal ligament and yet it is considered to be a variety of the spinal geriatric conditions, favorable to the cervical spine. The condition develops similar symptoms of cervical spondylosis. Authors report two cases of ossification of posterior longitudinal ligament of cervical spine of Korean nationals at St. Marys hospital, Catholic Medical College.
Japan ; Longitudinal Ligaments ; Ossification of Posterior Longitudinal Ligament ; Spine ; Spondylosis

The congenital dislocation of the hip is one of the most common congenital disease of the infants. The diagnosis and treatment of comgemital dislocation of the hip has been developcd since Lorenz published the methods of the closed reduction and immobilization in 1895. By replacing the displaced femoral head in the acetabular socket in early time, the normal development of acetabulum and femoral head were expected. So the early diagnosis and treatment were very important for good results. The authors studied 19 cases of 18 patients of congenital dislocation of the hip at the Department of Orthopedic Surgery of Hanyang University Hospital from June, 1972 to June, 1977. As results of this study, the following concolusion were result reached: 1. The proponderance of girl to boy was 13: 5. 2. The ratio of left side to right was 12:7. 3. The chief complaints were shortening of lower extremity, limitation of hip motion(esp. abduction) below 1 year old age and limping in over 1 year old age. 4. The associated congenital anomaly was abserved in a case of internal tibial torsion and metatarsus varus deformity. 5. In birth history, there was 1 case of breech presentation. 6. The acetabular index was much decreased in involved hip than the sound hip in treatment. 7. The arthrogram was valuable to detect any obstacles of closed reduction. 8. In 16 cases of 15 patients, 13 cases were treated by closed reduction, 1 case was open reduction, 1 case was derotation osteotomy, 1 case was varus and derotation osteotomy. 9. The results of treatment was Excellent:8 Good:8.
Acetabulum ; Breech Presentation ; Clinical Study ; Congenital Abnormalities ; Diagnosis ; Dislocations ; Early Diagnosis ; Female ; Head ; Hip ; Humans ; Immobilization ; Infant ; Lower Extremity ; Male ; Metatarsus ; Orthopedics ; Osteotomy ; Pregnancy ; Reproductive History