No abstract available.
Humans ; Osteosarcoma*

Liver function tests before treatment showed abnormalities of liver function tests during treatment, while 15(68. 2%) of 22 patients who had abnormal liver function tests before treatment showed abnormalities during treatment. In 12 of the 25 patients who showed abnormalities of liver function tests during treatment with allopurinol, allopurinol was stopped and all patients showed improvement of liver function tests. In remaining 13 patients, 10 patients were improved and other 2 patients showed only mild abnormalities of liver function tests despite of continuing allopurinol and 1 patient was lost during follow-up. CONCLUSION: Abnormalities of liver function tests were common during treatment with allopurinol. Most patiensts who had mild abnormalities of liver functions tests during treatment with allopurinol were improved regardless of continuing allopurinol.
Allopurinol* ; Follow-Up Studies ; Gout* ; Humans ; Liver Function Tests* ; Liver*

The purpose of this study was to evaluate the Waters' views, panoramic and periapical radiograms as well as clinic al symptoms in the diagnosis of maxillary sinusitis. The author analyzed the types of mucosal thickenings, the types of bony wall changes, the pathologic changes of antra l floors and total amount of agreement on radiograms in 495 patients with 505 maxillary sinuses which demonstrated radio graphic changes. The results were obtained as follows : 1. 125 cases (24.8%) showed the mucosal thickening of antral floor and lateral wall(Type II), 106 cases (20.9%) showed the mucosal thickening around the whole antral wall(Type IV) and 75 cases (14.8%) showed increased radiopacity of whole antrum. 2. Among 505 cases of mucosal thickening, 319 cases(63.2%) showed the bony wall changes: 114 cases (35.9%) showed the thining of lateral walls, 105 cases(32.8%) showed the thickening of lateral walls and 47 cases(14.7%) showed indistinct antral walls. 3. Among 6 types of mucosal thickenings, the incidence of bony wall changes was high in type VI(73.3%) and in type IV(7 1.6%). 4. 139 cases(25.1%) showed no pathologic change of antral floor, 127 cases(22.9%) showed the indistinct antral floor an d 022 cases (22.1%) showed the halo appearance of antral floor on panoramic and periapical radiograms. 5. 449 cases(88.9%) showed apparent increased radiopacity and 47 cases(9.3%) showed suspicious increased radiopacity on Waters' views. 280 cases(71.6%) showed apparent increased radiopacity and 88 cased (22.5%) showed suspicious increased radiopacity on panoramic radiograms. And 141 cases(31.6%) showed apparent increased radiopacity and 133 cases(33.4%) showed suspicious increased radiopacity on periapical radiograms.
Diagnosis ; Humans ; Incidence ; Maxillary Sinus* ; Maxillary Sinusitis*

The purpose of this study was to evaluate the Waters' views, panoramic and periapical radiograms as well as clinic al symptoms in the diagnosis of maxillary sinusitis. The author analyzed the types of mucosal thickenings, the types of bony wall changes, the pathologic changes of antra l floors and total amount of agreement on radiograms in 495 patients with 505 maxillary sinuses which demonstrated radio graphic changes. The results were obtained as follows : 1. 125 cases (24.8%) showed the mucosal thickening of antral floor and lateral wall(Type II), 106 cases (20.9%) showed the mucosal thickening around the whole antral wall(Type IV) and 75 cases (14.8%) showed increased radiopacity of whole antrum. 2. Among 505 cases of mucosal thickening, 319 cases(63.2%) showed the bony wall changes: 114 cases (35.9%) showed the thining of lateral walls, 105 cases(32.8%) showed the thickening of lateral walls and 47 cases(14.7%) showed indistinct antral walls. 3. Among 6 types of mucosal thickenings, the incidence of bony wall changes was high in type VI(73.3%) and in type IV(7 1.6%). 4. 139 cases(25.1%) showed no pathologic change of antral floor, 127 cases(22.9%) showed the indistinct antral floor an d 022 cases (22.1%) showed the halo appearance of antral floor on panoramic and periapical radiograms. 5. 449 cases(88.9%) showed apparent increased radiopacity and 47 cases(9.3%) showed suspicious increased radiopacity on Waters' views. 280 cases(71.6%) showed apparent increased radiopacity and 88 cased (22.5%) showed suspicious increased radiopacity on panoramic radiograms. And 141 cases(31.6%) showed apparent increased radiopacity and 133 cases(33.4%) showed suspicious increased radiopacity on periapical radiograms.
Diagnosis ; Humans ; Incidence ; Maxillary Sinus* ; Maxillary Sinusitis*

The melanotic neuroectodermal tumor of infancy is a rare neoplasm arising in the first year of life. A 33-day-old female infant had an enlarged alveolar ridge on the right anterior maxilla. Intraoral examination revealed a nonulcerative swelling at the site. An intraoral radiograph showed an ill-defined radiolucency on the right anterior maxilla and displacement of primary incisors from their alveolar sockets. CT scans revealed an expansion of the surrounding bone and partial destruction of the anterior wall of the premaxilla. Histopathologic examination showed the cytoplasm of neuroblastic cells and eosinophilic, epithelioid cells frequently contained a dark brown granular pigment that stained positively to vimentin and HMB45, focally positive to NSE and cytokeratin. Four weeks after the operation, CT scans showed a rapidly growing soft tissue mass occupying right maxillary sinus encroaching to the orbit and nasal cavity. The final diagnosis was made as a malignant melanotic neuroectodermal tumor of infancy.
Alveolar Process ; Cytoplasm ; Diagnosis ; Eosinophils ; Epithelioid Cells ; Female ; Humans ; Incisor ; Infant ; Keratins ; Maxilla ; Maxillary Sinus ; Nasal Cavity ; Neuroectodermal Tumor, Melanotic* ; Neuroectodermal Tumors ; Orbit ; Tomography, X-Ray Computed ; Vimentin

The melanotic neuroectodermal tumor of infancy is a rare neoplasm arising in the first year of life. A 33-day-old female infant had an enlarged alveolar ridge on the right anterior maxilla. Intraoral examination revealed a nonulcerative swelling at the site. An intraoral radiograph showed an ill-defined radiolucency on the right anterior maxilla and displacement of primary incisors from their alveolar sockets. CT scans revealed an expansion of the surrounding bone and partial destruction of the anterior wall of the premaxilla. Histopathologic examination showed the cytoplasm of neuroblastic cells and eosinophilic, epithelioid cells frequently contained a dark brown granular pigment that stained positively to vimentin and HMB45, focally positive to NSE and cytokeratin. Four weeks after the operation, CT scans showed a rapidly growing soft tissue mass occupying right maxillary sinus encroaching to the orbit and nasal cavity. The final diagnosis was made as a malignant melanotic neuroectodermal tumor of infancy.
Alveolar Process ; Cytoplasm ; Diagnosis ; Eosinophils ; Epithelioid Cells ; Female ; Humans ; Incisor ; Infant ; Keratins ; Maxilla ; Maxillary Sinus ; Nasal Cavity ; Neuroectodermal Tumor, Melanotic* ; Neuroectodermal Tumors ; Orbit ; Tomography, X-Ray Computed ; Vimentin

OBJECTIVES: The purpose of this study was to evaluate the optimal distance and angle of observers by modulation transfer functions(MTFs) and receiver operating characteristics(ROCs). MATERIALS AND METHODS: Digital periapical radiograms were taken from 43 patients who have dental diseases(19 patients : dental caries, 12 patients : periapical lesions, 12 patients : periodontal diseases). Segmental images(4x4cm) were evaluated by 4 MTFs and ROC analysis. RESULTS: The optimal distance(magnification) using MTF by Mannos & Sakrison was 12.97, and those by Nill, Ngan and Rao were 8.39, 4.78, 5.84 respectively. The optimal distance obtained from 4 radiologists by ROC analysis was 32cm(Az value : 0.89), and it was 40cm(Az value : 0.78) from 4 non-radiologists. There were significant differences of Az values between 4 radiologists and 4 non-radiologists at 24, 32 and 40cm (p<0.05). No significant differences of optimal distances were observed using 4 MTFs among +20, +10, 0, -10, -20 degrees(p>0.05). The optimal angle obtained from 4 radiologists by ROC analysis was +20 degrees (Az value : 0.91), and no significant differences of Az values were observed among +20, +10, 0, -10 and 20 degrees(p>0.05). The optimal angle obtained from 4 non-radiologists by ROC analysis was 0 degree(Az value : 0.81), and no significant differences of Az values were observed among +20, +10, 0, -10 and 20 degrees(p>0.05). And there was significant difference of Az value between 4 radiologists and 4 non-radiologists at +20 degree(p<0.05), but no significant differences of Az values were observed among +10, 0, -10 and -20 degrees(p>0.05).
Dental Caries ; Humans ; ROC Curve

The purpose of this study was to aid in the use of the digital images by edge-detect interpolation for direct digital periapical images using edge-deted interpolation. This study was performed by image processing of 20 digital periapical images; pixel replication, linear non-interpolation, linear interpolation, and edge-sensitive interpolation. The obtained results were as follows ; 1. Pixel replication showed blocking artifact and serious image distortion. 2. Linear interpolation showed smoothing effect on the edge. 3. Edge-sensitive interpolation overcame the smoothing effect on the edge and showed better image.
Artifacts

The purpose of this study was to compare E-speed film, CDR, and modified CDR images by means of observing some artificial defects of alveolar bone wall in the sound human dried mandibles. High diagnostic accuracy was shown in 1 wall and 4 wall defects by all 5 observers (2 Radiologists, 2 Periodontists, 1 General practitioner), but the diagnosis in 2 wall and 3 wall defects was inaccurate. Modified CDR images had the more diagnostic accuracy than E-speed film and CDR images, but there was no statistical difference among them. Finally, radiologist used modified CDR images more than others and used equalization effect more than the change in contrast and/or brightness.
Diagnosis ; Humans ; Mandible ; Radiographic Image Enhancement*

The purpose of this study was to aid in the prediction of tumor cell tolerance to radiotherapy and/or chomotherapy . For this study, cell surviving curves were obtained for mouse lymphoma YAC-1 cell line using semiautomated MTT assay. 2, 4, 6, 8, 10Gy were irradiated at a dose rate of 210cGy/min using 60Co Irradiator ALDORADO 8. After irra diation, YAC-1 cell lines(3X10(4) cells/ml) were exposed to bleomycin or cisplatin for 1 hour. The viable cells were determined for each radiation dose and/or each concentration of drug at the 4th day. And they w ere compared to control values. The obtained results were as follows: 1. The surviving curve with gentle slope was obtained after irradiation of 2, 4, 6, 8, 10Gy on YAC-1 cell line. 2. The cytotoxicity of bleomycin or cisplatin was increased significantly at all concentration of 0.2microgram/ml, microgram/ml an d 20microgram/ml on YAC-1 cell line (P<0.01). 3. There were no significant differences of surviving fractions among 4Gy, 6Gy, and 8Gy after irradiation of each radia tion dose with 2microgram/ml of bleomycin compared with irradiation only on YAC-1 cell line(P<0.05). 5. There were significant differences of surviving fractions between the groups of irradiation only and the groups of i rradiation with 2microgram/ml of bleomycin or cisplatin at all doses of 2, 4, 6, 8 and 10Gy on YAC-1 cell line(P<0.05).
Animals ; Bleomycin ; Cell Line* ; Cisplatin ; Lymphoma ; Mice ; Radiation Tolerance* ; Radiotherapy