No abstract available.
Denture, Partial, Removable*

No abstract available.

No abstract available.

Horseshoe kidney is a nonfatal anomaly of renal development characterized by fusion of one poles of both kidneys. Most clinical problems are caused by infection, hydronephrosis and renal calculi. Herein, we report a case of horseshoe kidney with staghorn calculi and hydronephrosis in a 66 year-old-woman. The patient was managed by division of the isthmus and left nephrectomy with a good result.
Calculi* ; Humans ; Hydronephrosis* ; Kidney Calculi ; Kidney* ; Nephrectomy

Squamous cell carcinoma of the renal pelvis is an uncommon tumor, comprising about 0.5-2% of all primary malignant tumor of the kidney. The patients of this disease usually presented late with extensive local infiltration. In addition, poor response to surgery, radiotherapy and chemotherapy result in a poor prognosis and short survival. We report a patient of squamous cell carcinoma of renal pelvis with staghorn calculi in a 66-year-old woman who had a history of right sided renal colic and palpable abdominal mass.
Aged ; Calculi* ; Carcinoma, Squamous Cell* ; Drug Therapy ; Female ; Humans ; Kidney ; Kidney Pelvis* ; Prognosis ; Radiotherapy ; Renal Colic

The authors experienced 21 myasthenia gravis patients who were admitted to Kyung Hee University Hospital and Han Yang University Hospital from March 1979 to August 1983. Following results were obtained through treatment and follow up evaluation. 1. There was no sexual difference between male and female, of 21 patients male to female ratio was 10:11. The prevalent age group was 20s and 30s. (10 of 21 patients, 47.6%). 2. The most common initial symptom was ptosis (71.4%), followed by diplopia (38.0%), generalized muscle weakness (38.0%), swallowing difficulty(19.0%), Mastication difficulty (9.5%), dysarthria (4.8%), respiratory difficulty (4.8%), in order. 3. Among 21 patients, thymomas were found in 2 patients. (9.5%) 4. According to the modified Osserman's classification, the peak incidence group was IIA (7 cases, 33.3%) then IIB (5 cases, 23.8%). Group III and neonatal type were not seen. 5. In 14 patients (66.6%), diagnosis was made within 1 year after the onset of the symptoms, but the other 7 patients (33.3%) spent more than 1 year for the diagnosis. 6. All patients who received corticosteroid therapy or thymectormy were improved significantly after the treatment. 7. After the discharge, 3 patients (14.3%) make normal life, on the other hand 17 patients (80.9%) are in more or less restricted life.
Classification ; Deglutition ; Diagnosis ; Diplopia ; Dysarthria ; Female ; Follow-Up Studies ; Hand ; Humans ; Incidence ; Male ; Mastication ; Muscle Weakness ; Myasthenia Gravis* ; Thymoma

The authors experienced 21 myasthenia gravis patients who were admitted to Kyung Hee University Hospital and Han Yang University Hospital from March 1979 to August 1983. Following results were obtained through treatment and follow up evaluation. 1. There was no sexual difference between male and female, of 21 patients male to female ratio was 10:11. The prevalent age group was 20s and 30s. (10 of 21 patients, 47.6%). 2. The most common initial symptom was ptosis (71.4%), followed by diplopia (38.0%), generalized muscle weakness (38.0%), swallowing difficulty(19.0%), Mastication difficulty (9.5%), dysarthria (4.8%), respiratory difficulty (4.8%), in order. 3. Among 21 patients, thymomas were found in 2 patients. (9.5%) 4. According to the modified Osserman's classification, the peak incidence group was IIA (7 cases, 33.3%) then IIB (5 cases, 23.8%). Group III and neonatal type were not seen. 5. In 14 patients (66.6%), diagnosis was made within 1 year after the onset of the symptoms, but the other 7 patients (33.3%) spent more than 1 year for the diagnosis. 6. All patients who received corticosteroid therapy or thymectormy were improved significantly after the treatment. 7. After the discharge, 3 patients (14.3%) make normal life, on the other hand 17 patients (80.9%) are in more or less restricted life.
Classification ; Deglutition ; Diagnosis ; Diplopia ; Dysarthria ; Female ; Follow-Up Studies ; Hand ; Humans ; Incidence ; Male ; Mastication ; Muscle Weakness ; Myasthenia Gravis* ; Thymoma

No abstract available.
Carcinogenesis* ; Humans* ; Oncogenes*

No abstract available.
Carcinogenesis*

Human monoclonal antibodies have considerable potential in the prophylaxis and treatment of viral disease. By cloning human Ig gene segments from the B cells of volunteer into pComb3 phagemid vector, antibody library was created of filamentous phage particles displaying Fab fragments on their surface after being rescued with M13KO7 helper phages. The size of library was 7x10' pfu. Phage antibodies (phabs) were panned against biotinylated preS1 using streptavidine coated Dynabead. The soluble Fab antibodies were prepared from phagemid colonies and assayed directly for the ability to bind preS1 by ELISA. And then 3DW and SGW specific to preS1 which have both heavy and light chain to form Fab fragment, were selected. The soluble Fab antibody from 3DW was expressed highly at the concentration of 0.1 - 1.0 mM of IPTG, and 5 hours postinduction. The soluble antibodies from 3DW and SGW showed their relative affinities of 2x10' M ', and Sx10 M ', respectively, and the specificities to preS1 on ELISA. Our results suggest that antibody phage display library is very useful method to generate the human monoclonal antibody and that the human Fab monoclonal antibodies specific to preS1 selected in this study open the way to treat hepatitis B as a component of passive irnmunotherapeutics.
Antibodies ; Antibodies, Monoclonal ; B-Lymphocytes ; Bacteriophages* ; Clone Cells ; Cloning, Organism ; Enzyme-Linked Immunosorbent Assay ; Genes, Immunoglobulin ; Hepatitis B virus* ; Hepatitis B* ; Hepatitis* ; Humans* ; Immunoglobulin Fab Fragments ; Isopropyl Thiogalactoside ; Streptavidin ; Virus Diseases ; Volunteers