No abstract available.
Anemia* ; Gastrectomy* ; Vitamin B 12 Deficiency* ; Vitamin B 12* ; Vitamins*

The antihypertensive effect and side reactions of perdipine were evaluated in 30 patients with essential hypertension. The results were as follows; 1) Before medication and after 2, 4, 5 and 8 weeks of medication, the over all average systolic and diastolic blood pressure were 170+/-13/104+/-7, 152+/-13/93+/-6, 146+/-11/91+/-6, 143+/-9/90+/-7, and 141+/-10/89+/-7mmHg, respectively. In 89% of all cases, marked or moderate degree of antihypertensive effect was observed. 2) There were no significant changes in heart rates before and after treatment. 3) In 83% of all cases, improvement of symptoms were observed. 4) The side reactions of oral perdipine were mild constipation, anorexia, facial flushing, dizziness, and headache, respectively one case. but there were no side reactions which required discontinuing the treatment, except 1 case which discontinued the medication because of severe bradycardia and dizziness.
Anorexia ; Blood Pressure ; Bradycardia ; Constipation ; Dizziness ; Flushing ; Headache ; Heart Rate ; Humans ; Hypertension ; Nicardipine*

No abstract available.
Animals ; Chiroptera* ; Korea* ; Murinae* ; Polymerase Chain Reaction* ; Puumala virus

Kimura's disease is a chronic inflammatory disorder of unknown cause and is most prevalent among Asians. The cytologic findings of Kimura's disease are significant numbers of eosinophils in a background of lymphoid cells, occasional fragments of collagenous tissue, proliferation of vessels, and Warthin-Finkeldey polykaryocytes. Among these features, the most important cytologic feature of Kimura's disease is a significant numbers of eosinophils. We experienced a case of Kimura's disease in the parotid gland which we failed to recognize on cytology due to the apparent paucity of eosinophils. On careful retrograde reviewing of the cytologic findings, a few scattered leukocytes, previously interpreted as polymorphous leukocytes, had bilobed nuclei and coarse green but granular cytoplasm on Papanicolaou preparation. These leukocytes showed obvious orange-red intracytoplasmic granules as in eosionophils on Giemsa stain. The paucity of eosinophils may be due to the thick fibrosis around lymphoid follicles or any technical error during aspiration. Whereas the Warthin-Finkeldey type giant cell is not a sensitive cytologic marker of Kimura's disease, it may be a helpful cytologic feature. To reach a correct cytologic diagnosis of Kimura's disease, it is important to keep in mind that searching for Warthin-Finkeldey type giant cells and evaluation of Giemsa stain for detection of eosinophils would be helpful.
Asian Continental Ancestry Group ; Azure Stains ; Biopsy, Fine-Needle* ; Collagen ; Cytoplasm ; Diagnosis ; Eosinophils ; Fibrosis ; Giant Cells ; Humans ; Leukocytes ; Lymphocytes ; Parotid Gland*

There is increasing evidence that genes involved in normal cell growth and differentiation (oncogenes) or genes that encode for growth factors are important in determining the development and biologic aggressiveness of gastric carcinoma. This study was undertaken to define the prognostic value of the overexpression of p53 protein, c-erbB-2 protein, EGFr protein and PCNA in gastric carcinomas. Using monoclonal antibodies, immunohistochemical studies were performed on formalin-fixed, paraffin-embedded tissue sections from 84 primary gastric carcinomas. Overall, 34% of gastric carcinomas had nuclear-staining for p53 protein, 34% of carcinomas membrane staining for the c-erbB-2 and 74% of carcinomas membrane and cytoplasmic staining for EGFr, showing distribution in a heterogeneous fashion. PCNA was expressed as Grade 2 and 3 in 75% of patients with gastric carcinomas. Both c-erbB-2 and p53 staining was significantly associated with high grade expression of PCNA. p53 staining tended to be associated with positive nodal status and metastasis, and c-erbB-2 staining with positive nodal status only. Multivariate analysis using the Cox model showed that overexpression of p53 protein, c-erbB-2 protein and PCNA was not an independent prognostic variable in gastric carcinoma. These results suggest that expressions of p53 and c-erbB-2 protein are heterogeneous and that p53 and c-erbB-2 overexpressions are significantly associated with high proliferative activity in gastric carcinoma.
Antigens, Neoplasm/analysis ; Humans ; Immunohistochemistry ; Multivariate Analysis ; Neoplasm Proteins/analysis ; Nuclear Proteins/*analysis ; Prognosis ; Proliferating Cell Nuclear Antigen ; Proto-Oncogene Proteins/*analysis ; Receptor, Epidermal Growth Factor/*analysis ; Receptor, erbB-2 ; Retrospective Studies ; Stomach Neoplasms/*chemistry/immunology/mortality ; Survival Rate ; Tumor Suppressor Protein p53/*analysis

No abstract available.
Incidence

BACKGROUND: The macrofollicular variant of papillary thyroid carcinoma (MVPC) is characterized by macrofollicles occupying more than half of the tumor and demonstrating nuclear features of classic papillary carcinoma. It is difficult to recognize on fine needle aspiration (FNA) cytology due to the paucity of aspirated neoplastic cell clusters, especially when the tumor is associated with extensive areas of hemorrhage. CASE: A 34-year-old female presented with a well-demarcated nodule in the thyroid gland, diagnosed as a benign nodule on ultrasonography and computed tomography. FNA cytology smear revealed a few small aggregates of follicular cells with morphological features suspicious for papillary carcinoma, set in a background of hemorrhage, inflammatory cells, and hemosiderin-laden macrophages. Intraoperative frozen section revealed macrofollicular nests filled with hemorrhage and composed of follicular cells demonstrating nuclear clearing and grooves. CONCLUSION: MVPC is a rare but distinctive variant of papillary carcinoma, which is easily mistaken for adenomatous goiter or benign macrofollicular neoplasm on radiologic findings. The cytopathologist should alert oneself on encountering benign radiologic findings and any smear composed of scant numbers of follicular cells with nuclear features suspicious for papillary carcinoma despite the bland-looking background of hemorrhage and hemosiderin-laden macrophages, and recommend intraoperative frozen sections for a definite diagnosis.
Adult ; Biopsy, Fine-Needle ; Carcinoma, Papillary ; Diagnosis ; Female ; Frozen Sections ; Goiter ; Hemorrhage* ; Humans ; Macrophages ; Thyroid Gland* ; Thyroid Neoplasms* ; Ultrasonography

OBJECTIVES: The authors studied the effects of cigarette smoking on the cognitive function with topographic mapping of auditory event-related potential P300. METHODS: The subjects, 24 smokers and 14 nonsmokers, were assessed in the latencies and amplitudes of topographic auditory event-related potential P300 determined by Global Field Power Measurement. RESULTS: 1) There were significant differences of P300 latencies between smokers and controls artier smoking(ANOVAL F=10.45, P=0.0026). 2) There were no significant differences of P300 amplitude but a trend was present between smokers and nonsmokers after smoking(ANOVAL F=3.77, P=0.06). 3) There were no significant differences of difference between amplitude in maximal point and amplitude in minimal point but a trend was present between smokers and nonsmokers artier smoking(ANOVAL F=3.68, P=0.063). 4) There were no significant differences of maximal point in X-axis and in Y-axis, minimal point in X-axis and in Y-axis of P300 between smokers and nonsmokers artier smoking. CONCLUSIONS: These results support that auditory event-related potential P300 change by cigarrete smoking is indicative of enhanced cognitive function.
Evoked Potentials* ; Smoke ; Smoking* ; Tobacco Products*

Vigabatrin (gamma vinyl GABA) was used in an open study of add-on therapy in adult patients with refractory epilepsy. Sixteen chronic epileptic patients (9 males and 7 females) with eight complex partial seizure, seven generalized tonic-clonic seizure and one rnixed seizure were selected from the Neurology department in St. Mary's Hospital of CUMC. Mean duration of epilepsy was 14. 1years, and mean frequency of epileptic attack was 5.2 times a month. Before the entry for the study, all the patients had optimal serum drug levels and were taking one antiepileptic drug to limit of their tolerance. Maintenance doses of vigabatrin ranged from 2 to 3 gram/day. Seizure counts and safety data were assessed at intervals during 6 months follow-up period. Three patients complained of dizziness and G-I trouble and one patient gained weight. No changes in routine laboratory tests and EEG were observed during drug administration. Following administration of 2-3 gram/day vigabatrin, a 75-100% reduction in seizure frequency was observed in 31.3% of patients, and a 50-74% decrease in a further 18.8%. In 37.5% of the patients, the seizure frequency was not changed and more aggravated in one patient. Vigabatrin thus appears to be a well tolerated drug with antiepileptic efficacy in drug resistant cases.
Adult ; Dizziness ; Electroencephalography ; Epilepsy* ; Follow-Up Studies ; Humans ; Male ; Neurology ; Seizures ; Vigabatrin*

The ischemic coitis proximal to obstructive colon cancer was firstly reported by MacCallum and Kaisch in 1947. Nowsdays, its clinical importance and the study of pathogenesis is reported frequently. Because of the rare inciedence of this complicated condition this lesion could be overlooked which then could result anastomotic leakage, fecal fistula and peritonitis. Recently, we have examined a 61 year-old Korean male patient who had the complaints of acute abdominal pain and bloody diarrhea. The diagnosis of gangrenous ischemic colitis associated with obstucting rectal cancer was confirmed on the basis of sigmoidoscopic and operative and associated histopathological findings. After prompt surgical intervention, the patient was discharged with good improvement. The literatures are reviewed here with the case presentation.
Abdominal Pain ; Anastomotic Leak ; Colitis, Ischemic* ; Colonic Neoplasms ; Diagnosis ; Diarrhea ; Fistula ; Humans ; Male ; Middle Aged ; Peritonitis ; Rectal Neoplasms