1.Stress and Psychoneuroendoimmunology.
Kwang Ho PYUN ; Hun Taeg CHUNG
Journal of Korean Society of Endocrinology 2000;15(6):696-707
No Abstract Available.
2.Effects of Interleukin 4 on the Production of Interleukin 6 in Human Keratinocytes.
Sang Hyun CHO ; Jin Wou KIM ; Kwang Ho PYUN ; Chung Won KIM ; Won HOUH
Korean Journal of Dermatology 1995;33(5):847-854
BACKGROUND: The human keratinocyte can synthesize interleukin 6 (IL-6) under certain conditions, and the IL-6 synthesis is inhibited by interleukin 4 (IL-4) in the human monocyte. OBJECTIVE: To find out what kind of stimulating agents can induce the IL-6 production and whether IL-4 affects the production of IL-6 in the human cultured keratinocytes. METHODS: We stimulated the keratinocytes with either lipopolysaccharide (LPS), fetal bovine serum (FBS), human recombinant interferon-gamma(IFN-gamma) to induce the IL-6 production, and treated the keratinocytes, which stimulated either with 10% FBS or human recombinant IFN-gamma, with human recombinant IL-4. RESULTS: The LPS stimulation resulted in no increase of IL-6 levels in the keratinocyte supernatants. When the keratinocytes were stimulated either with 1%, 5%, 10% FBS with or without 5 microgram/ml LPS, significantly increased amounts of IL-6 were detected. The level of IL-6 in the keratinocytes treated with the human recombinant IFN-gamma increased, too. The human recombinant IL-4 downregulates the secretion of IL-6 by the keratinocytes which were activated either with 10% FBS or human recombinant IFN-gamma. CONCLUSION: We have shown that it is possible to induce the IL-6 synthesis by stimulating the keratinocytes and that human recombinant IL-4 profoundly inhibits the synthesis of IL-6. So we suggest that there may be a cytokine network which regulates the primary immune response in the skin.
Humans*
;
Interleukin-4*
;
Interleukin-6*
;
Interleukins*
;
Keratinocytes*
;
Monocytes
;
Skin
3.Effects of IL-6 on the proliferation and ICAM-1 expression of keratinocytes.
Young YANG ; In Pyo CHOI ; Sang Hyun CHO ; Hyung Sik KANG ; Si Myung BYUN ; Kwang Ho PYUN
Korean Journal of Immunology 1993;15(2):183-189
No abstract available.
Intercellular Adhesion Molecule-1*
;
Interleukin-6*
;
Keratinocytes*
4.Regulation mechanisms of inflammatory response induced by Fc? stimulation in human monocytes and monocytic cell line, thp1.
Kang Soon YOON ; Suk Ran YOON ; Choong Eun LEE ; Hyung Soon KIM ; Kwang Ho PYUN
Korean Journal of Immunology 1993;15(2):163-171
No abstract available.
Cell Line*
;
Humans*
;
Monocytes*
5.Differentiation of human B lymphocytes by B cell stimulating cytokines.
Woo Jin NA ; Suk Ran YOON ; In Pyo CHOI ; Kwang Ho PYUN
Korean Journal of Immunology 1992;14(1):85-96
No abstract available.
B-Lymphocytes*
;
Cytokines*
;
Humans*
6.Interation of Immune and Nervous Systmes.
Hun Taeg CHUNG ; Myeong Soo LEE ; Hyun Ock PAE ; Kwang Ho PYUN
Journal of Korean Society of Endocrinology 2000;15(6):684-695
No Abstract Available.
8.Regulation of transforming growth factor-beta1 synthesis by nurine T lymphocytes and its effect of IgA antibody response.
Kyoung Bum SEO ; Se Won YIE ; Inpyo CHOI ; Kwang Ho PYUN ; Pyeung Hyeun KIM
Korean Journal of Immunology 1992;14(2):203-211
No abstract available.
Antibody Formation*
;
Immunoglobulin A*
;
T-Lymphocytes*
9.The roles of interleukin-6 in fibrosis.
Hyung Sik KANG ; Inpyo CHOI ; Jeong Sang LEE ; Kwang Ho PYUN
Korean Journal of Immunology 1992;14(2):193-202
No abstract available.
Fibrosis*
;
Interleukin-6*
10.The effects of monokines on neutrophil activation.
Su Yeon KIM ; Hyung Sik KANG ; Jeong Sang LEE ; Suk Ran YOON ; Choong Eun LEE ; Kwang Ho PYUN
Korean Journal of Immunology 1991;13(2):135-142
No abstract available.
Monokines*
;
Neutrophil Activation*
;
Neutrophils*
Result Analysis
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