Dermal wound healing is a complex process that involved inflammation leading to re-epithelialization, granulation tissue, and tissue remodeling. Previous studies from our laboratory have shown that polysaccharides isolated from fungus, Phellinus gilvus (PG) have various anti-inflammatory activities. In present study, we have assessed the effect of polysaccharides from PG on the dermal wound healing of polysaccharides from PG in streptozotocin-induced diabetic rat model. Six of 6-mm circular wounds were created with biopsy punch on the 4th day after induction of diabetes. After 24 hours, each test substance was applied to the wound twice a day for next 5 days. Circular wounds treated with PG showed significantly reduced wound contraction and complete reepithelialization, as compared to wounds of non-treated (p < 0.05). These results show that polysaccharides isolated from PG enhanced wound repair in diabetic impaired healing, and could be developed as a wound healing agent in such clinical settings.
Administration, Cutaneous ; Animals ; Anti-Inflammatory Agents/pharmacology ; Basidiomycota/*metabolism ; Diabetes Mellitus, Experimental/*pathology ; Histocytochemistry ; Male ; Polysaccharides/isolation&purification/*pharmacology ; Rats ; Rats, Sprague-Dawley ; Skin/*injuries ; Streptozocin ; Wound Healing/*drug effects ; Wounds, Penetrating/*drug therapy

No abstract available.
Escherichia coli* ; Escherichia* ; Humans ; Urinary Tract Infections* ; Urinary Tract*

No abstract available.
Tendon Injuries* ; Tendons*

In the treatment of Tb.knee, the preservation of mobility is an important issue, there are many difficulties due to pain and swelling in the trial of early ROM exercise, and various problems such as the recurrence of Tb. lesions, delayed wound healing and draining sinus formation. We analysed 30 cases of Tb. knee treated with synovectomy during 10 years since March, 1979. In Group I (25 cases), early ROM exercise were started about 4 weeks after synovectomy. And in Group II (5 csses), arthroscopic adhesiolysis was performed after minimum 6 month immobilization and chemotherapy following synovectomy. We compared the two Groups and the results were as followings: 1. Male was 15 patients and female was 15 patients, the average age was 28.1 years. 2. The average follow-up period was 18.3 months. 3. In Group I, the ROM exercise was performed before 4 weeks in 9 cases and after 4 weeks in 16 cases postoperatively. The average final ROM was 68.9° 4. Draining sinus formation was in 4 cases in Group I. 5. In Group II, arthroscopic adhesiolysis was performed in 5 cases after synovectomy and chemotherapy for average 8.8 months ranging from 6 to 14 months. 6. The average final ROM at follow-up was 111° in Group II. 7. In a case with the severe involvement of bone and cartilage in Tb. lesion at the synovectomy, ROM was reduced gradually to 50° after arthroscopic adhesiolysis. We could gain ROM of 120° by TKR. 8. Draining sinus formation was not found in Group II.
Cartilage ; Drug Therapy ; Female ; Follow-Up Studies ; Humans ; Immobilization ; Joints ; Knee ; Male ; Methods ; Recurrence ; Wound Healing

No abstract available.
Nasal Bone*

No abstract available.
Animals ; Rats*

No abstract available.
Drug Therapy* ; Humans ; Retreatment*

Fractures of the capitellum humeri are rare and the recommendations for treatment vary. It can involve a significant portion of the articular surface, rendering the elbow joint unstable. In this situation, it is desirable to reduce and internally fix the capitellar fragment, because this restores the articular surface and augments joint stability. We experienced two cases of capitellar fractures which one case was spontaneously anatomical reduced and the other case was treated by open reduction. In one case the capitellar fragment was spontaneous reduced to a stable position although it was noticed radiographically as an unstable displaced fracture preoperatively. The other case was treated by open reduction and internal fixation with 3.5mm, small, AO, cannulated screw and K-wire. Both cases are reported here with references.
Elbow Joint ; Joints

DSA(Digital Subtractin Angiography) is a valuable diagnostic imaging method in many clinical fields, includingranal-related conditons. Sixty four renal DSA examinations were performed in 59 patients with renal-relateddiseases from Jan. 1984 to Dec. 1985. Summary of these were as follows: 1. Intraarterial (IA)-DSA is performed in6 cases, intravenous(IV)-DSA in 58 cases. In 58 Examinations of IV-DSA, diagnostic image quality is obtained in 51cases(88%). 2. In investigations of a possible renovascular etiology of hypertension, IV-DSA,is a safe, sensitiveand accurate method. On screening for evaluation of renovascular hypertension, RSP should be replaced with IV-DSA,because IV-DSA is moe sensitive and accurate and can detect not only anatomic change of renal arttery but alsofunctional hemodynamic change. 3. IV-DSA is valuable in diseases with morphologic changes of vessels. Incharacterization of a known renal mass, and evaluation of hematuria, suspected aneurym and renal trauma, IV-DSA isvery useful diagnostic imaging modality. 4. In evaluation of potential renal donors, IV-DSA is an accurate andsafe method with 82.4% of accuracy. IV-DSA also is useful in follow-up of allograft recipients. 5. Ininvestigation of diabetic nephropathy, glomerulonephritis, pyelonephritis, IV-DSA is little helpful. 6. Theadvantages of DSA are well known, particularly post-procedure process using computer programs is helpful forobtaining informations of hemodynamic change or time-sequence-curve of density etc. More technical improvementwith this modality is required for improvement of the image quality and resolution. And more accumulation ofclinical experience is required in order to increase the diagnostic accuracy.
Allografts ; Angiography, Digital Subtraction ; Diabetic Nephropathies ; Diagnostic Imaging ; Follow-Up Studies ; Glomerulonephritis ; Hematuria ; Hemodynamics ; Humans ; Hypertension ; Hypertension, Renovascular ; Mass Screening ; Methods ; Pyelonephritis ; Tissue Donors

Cutaneous metastasis from internal malignacy is recognized but infrequently occuring manifestation. The prostatic carcinoma rarely acts as a primary source for cutaneous metastasis. We report a case of cutaneous metstasis from prostatic carcinoma. A 82-year-old male presents multiple painless erythematous nodules on suprapubic area, having an episode of surgical removal of prostate carcinoma two years ago. Histologic finding shows atypical anaplastic cell infiltration at the dermis and subcutaneous tissue, forming dermal tumor island, and have features similar to primary prostatic carcinoma. Immunohistochemical staining for prostate specific antigen shows positive reaction within cells, can assist in localization of the metatatic adenocarcinoma to a prostate origin.
Adenocarcinoma ; Aged, 80 and over ; Dermis ; Humans ; Male ; Neoplasm Metastasis* ; Prostate ; Prostate-Specific Antigen ; Subcutaneous Tissue