Search Results

The formation, maintenance, and regeneration of bone is a complex precess involving the interactions of many cellular elements with systemic and local regulators. TGF-β is one of growth factors that play an important role in the formation and remodeling of bone. In vitro studies have suggested that TGF-β regulates chondrogenesis and possibly osteogenesis by affecting replication, gene expression, and structural protein synthesis in bone formation. We investigated the effect of TGF-β1 upon fracture callus formation and maturation in mature rate. Closed femoral shaft fracture was made consistently by three point stress technique after percutaneous intramedullary nailing. TGF-β1 was injected subperiosteally at the fracture site daily for 2 weeks. We examined the effect of TGF-β1 on the fracture healing process with the radiographic, densitometric, histologic, and immunohistochemical methods. The following results were obtained. 1. Radiographic examination demonstrated that TGF-β1 injection group appeared to have more abundant callus formation and earlier callus maturation as compared to the control group. 2. Bone densitometric examination revealed that TGF-β1 injection group had higher bone mineral density and content that the control group. 3. Thermographic examination revealed that TGF-β1 injection group had higher local temperature at the injection area than the control group. 4. Histologic examination suggested that TGF-β1 stimulates and accelerates fracture callus formation and endochondral bone formation. 5. Immunohistochemical examination revealed that chondrocytes at the fracture site in the TGF-β1 injection group seemed to produce type I collagen.
Bone Density ; Bony Callus ; Chondrocytes ; Chondrogenesis ; Collagen Type I ; Fracture Fixation, Intramedullary ; Fracture Healing ; Gene Expression ; In Vitro Techniques ; Intercellular Signaling Peptides and Proteins ; Osteogenesis ; Regeneration

1.Rates of Adverse Reactions Associated with Modified DPT Vaccine in Korean Infants and Children.

2.Facial nerve decompression in Melkersson-rosenthal syndrome.

3.Anatomical measurements of the paranasal sinuses using PNS CT.

4.Urinary Ca Excretion in Children Under the 2 Years of Age.

5.Morphological study on the development of human fetal kidney.

6.An Experimental Study about the Influence of TGF-β1 upon Fracture Callus Formation

7.A case of nucleus 22-channel cochlear implant.

8.A Case of Acute Renal Failure Associated with Rhabdomyolysis in Carbon Monoxide Intoxication.

9.Captopril in Children with Renovacular Hypertension.

10.A Case of Transient Complete Atrioventricular Block in Acute Viral Myocarditis.

Display Mode

Output Records

File Type