No abstract available.
Cerebrospinal Fluid* ; Cholesteatoma*

No abstract available.
Hypophysectomy*

No abstract available.
Cholesterol* ; Granuloma*

No abstract available.
Otitis Media* ; Otitis* ; Tympanoplasty*

No abstract available.
Animals ; Guinea Pigs* ; Guinea* ; Perilymph*

No abstract available.
Mouth* ; Oropharynx*

BACKGROUND: Intubation granuloma of the larynx occurs from direct mechanical irritation of mucosa from a traumatic or prolonged endotracheal intubation. Surgical excision can be accomplished with microlaryngeal instruments or with CO2 laser under general anesthesia. OBJECTIVE: To investigate clinical characteristics of intubation granuloma and to suggest a jet ventilation technique appropriate in general anesthesia. MATERIAL AND METHOD: The clinical presentation, management of 14 consecutive cases of intubation granuloma were reviewed retrospectively from August, 1989 to December, 1995. RESULTS: 1) Age distribution was mostly in the 20-49 years old group(86%). The ratio of male to female was 2:12, with female predominance. 2) The site of lesions were bilateral in 3 cases and unilateral in 11 cases(left in 2 cases, right in 9 cases). The locations were vocal process of arytenoid cartilage in 12 cases(86%), and posterior 1/3 of true vocal cord other than vocal process in 2 cases(14%). 3) Thirteen cases were developed after general anesthesia using endotracheal intubation and 1 case after endotracheal intubation in drug intoxication. Among the 13 cases of general anesthesia, there were 8 cases of Cesarian section delivery. 4) We used the suspension laryngoscope in all cases, high-frequency jet ventilation technique was used for anesthesia in 8 cases and neuroleptic anesthesia in 6 cases. The CO2 laser was used in 5 cases among the jet ventilation technique. There was no complication associated with jet ventilation. CONCLUSION: Jet-ventilation is a useful anesthetic technique in removal of intubation granuloma.
Age Distribution ; Anesthesia ; Anesthesia, General ; Arytenoid Cartilage ; Female ; Granuloma* ; High-Frequency Jet Ventilation ; Humans ; Intubation* ; Intubation, Intratracheal ; Laryngoscopes ; Larynx ; Lasers, Gas ; Male ; Mucous Membrane ; Retrospective Studies ; Ventilation ; Vocal Cords

We retrospectively analyzed 125 patients of salivary gland tumor operated at Asan medical center from 1989 to 1996. The most commonly involved gland was parotid(69.6%) and the most frequent tumor was pleomorphic adenoma(56%). The proportion of the malignancy was 25.8% in parotid, 17.6% in submandibular gland, respectively. Facial palsy was developed postoperatively in 29 patients, however, seven patients were lost of follow up because five were died of disease and two were transferred to other hospitals. Persistent facial palsy were seven:four in the benign tumor, three in the malignant tumor. Transient facial palsy were 15:12 in the benign tumor, three in the malignant tumor. In the transient facial palsy, 10 patients were recovered within three months. Among 32 malignant tumor, the number of recurrence or distant metastasis were 12:four were distant metastasis alone, two were metastasis to the cervical lymph node, four were local recurrence alone and two were local recurrence with distant metastasis. The highest recurrence of the tumor was found in high grade-mucoepidermoid carcinoma(83.3%). Overall tumor recurrences were significantly related to positive cervical lymph node metastasis or positive resection margin:recurrence rate of the positive lymph node metastasis was 44.4%(four of nine) and the recurrence rate of positive resection margin was 50%(seven of 14).
Chungcheongnam-do ; Facial Paralysis ; Follow-Up Studies ; Humans ; Lymph Nodes ; Neoplasm Metastasis ; Postoperative Complications* ; Prognosis* ; Recurrence ; Retrospective Studies ; Salivary Glands* ; Submandibular Gland

PURPOSE: Structural alterations of p53 and overexpression of the p53 protein are the most common genetic abnormalities in various kinds of human cancers. In this study, we examined the mutational status and the frequency of p53 mutations in head and neck squamous cell carcimona (HNSCC) cell lines. MATERIALS AND METHODS: 7 human head and neck squamous cell carcinoma cell lines were included in this analysis. Using polymerase chain reaction(PCR), single strand confonmation polymorphism(SSCP) and PCR-DNA sequencing analysis, we tested the mutational status of 7 cell lines. Exon 4~9 of the p53 gene was amplified for the direct DNA sequencing analysis. RESULTS: Our results showed 100% nuclear p53 immunostaining and 3 electrophoretic abnomalities by PCR-SSCP in three cancer cell lines and mutations of the p53 gene including 2 base substitutions and 1 base deletion were detected in 3 cancer cell lines using PCR directed DNA sequencing analysis. CONCLUSION: 7 HNSCC cell lines examined in this study provide excellent systems for study of gene therapy using p53 gene.
Carcinoma, Squamous Cell* ; Cell Line* ; Exons ; Genes, p53 ; Genetic Therapy ; Head* ; Humans ; Neck* ; Polymerase Chain Reaction ; Sequence Analysis, DNA

Oncocytic Schneiderian papilloma (OSP) is a rare neoplasm of the nose and paranasal sinuses, and is often mistaken histologically for papillary adenocarcinoma or even rhinosporidiosis. Recently, we experienced a case of oncocytic Schneiderian papilloma of the left maxillary sinus developed in 53-year-old female patient. She complained of unilateral nasal obstruction, bloody rhinorrhea and frontal headache. The tumor mass was resected surgically through intranasal endoscopic and Caldwell-Luc's approach. We report its clinical manifestations and histologic characteristics.
Adenocarcinoma, Papillary ; Female ; Headache ; Humans ; Maxillary Sinus* ; Middle Aged ; Nasal Obstruction ; Nose ; Papilloma* ; Paranasal Sinuses ; Rhinosporidiosis