1.Association of Prostate Specific Antigen (PSA) Velocity with Age and Initial PSA in Healthy Korean Men.
Young Sam CHO ; Kwan Joong JOO
Korean Journal of Andrology 2010;28(1):16-21
PURPOSE: Prostate specific antigen (PSA) is a test with relatively low specificity used for determination of risk for prostate cancer. PSA velocity (PSAV) has been used as a complimentary test. We investigated the association of PSAV with age and an initial PSA. MATERIALS AND METHODS: We enrolled 989 healthy men with initial PSA of 4.0ng/ml or lower. The PSA levels were measured at intervals of at least 12 months. We analyzed the influence of age and initial PSA on the PSAV. RESULTS: PSAV was directly correlated with age and the initial PSA. The initial PSA was not correlated with the PSAV when adjusted by age (r=0.009, p=0.773); age was correlated with PSAV when adjusted by initial PSA level (r=0.276, p<0.001). The mean PSAV in cases with initial PSA of 2.1-4.0 ng/ml was significantly greater compared to the cases with an initial PSA of 0-2.0 ng/ml (p<0.01). The ratio of the men with a PSAV greater than 0.75 ng/ml/year was significantly higher in cases with an initial PSA of 2.1-4.0 ng/ml (p<0.05). CONCLUSIONS: PSAV is associated with age and an initial PSA level in healthy Korean men. Men with initial PSA of 2.1-4.0 ng/ml had an abnormal PSAV in high proportion, and therefore annual follow up PSA would be useful for the early detection of prostate cancer in these cases.
Follow-Up Studies
;
Humans
;
Male
;
Prostate
;
Prostate-Specific Antigen
;
Prostatic Neoplasms
;
Sensitivity and Specificity
2.A Case of Atrial Septal Defect in Identical Twins.
Jong Tae LEE ; Hun Kwan LIM ; Tae Myeung CHOI ; Sung Koo KIM ; Young Joo KWON
Korean Circulation Journal 1994;24(5):722-725
Atrial septal defect is one of the most common congenital heart diseases in adult, of which absolute causes is not confirmed, but explained by multifactorial inheritance. In Korea, there has been no case report of atrial septal defect in identical twins in spite of some reports of atrial septal defect in relatives and twins in other countries. We present a first case of atrial septal defect in identical twins whose mother had no infection or medication history during pregnancy.
Adult
;
Heart Diseases
;
Heart Septal Defects, Atrial*
;
Humans
;
Korea
;
Mothers
;
Multifactorial Inheritance
;
Pregnancy
;
Twins
;
Twins, Monozygotic*
3.A Short-Term In-Vitro Chemosensitivity Test for Ovarian Cancer: Nuclear Damage Assay.
Young Tak KIM ; Kwan Ja JI ; Yong Man KIM ; Joo Hyun NAM ; Jung Eun MOK
Korean Journal of Gynecologic Oncology and Colposcopy 1997;8(1):47-54
No abstract available.
Ovarian Neoplasms*
4.Persistence of antibodies after immunization with the inactivated vaccine against hemorrhagic fever with renal syndrome in humans.
Chang Hong LEE ; Kwan Soo BYUN ; Woo Joo KIM ; Young Dae WOO ; Ho Wang LEE
Journal of the Korean Society of Virology 1992;22(2):239-243
No abstract available.
Antibodies*
;
Hemorrhagic Fever with Renal Syndrome*
;
Humans*
;
Immunization*
5.Anticardiolipin antibody and pregnancy outcomes.
Ki Jung HAN ; Kwan Young JOO ; Duck Ho BAE ; Myung A LEE ; Sung Jin CHO ; In Suh PARK
Korean Journal of Obstetrics and Gynecology 1993;36(6):755-763
No abstract available.
Antibodies, Anticardiolipin*
;
Female
;
Pregnancy
;
Pregnancy Outcome*
;
Pregnancy*
7.A Case of Hemispherectomy for the Treatment of Infantile Hemiplegia with Uncontrolled Epilepsy.
Soon Kwan CHOI ; Joo Myung KIM ; Duck Young CHOI ; Kwang Seh RHIM
Journal of Korean Neurosurgical Society 1977;6(2):519-524
Infantile hemiplegia is the end state of various pathological conditions affecting the cerebral hemisphere before or during birth, or in first few years of life. In 1950, Krynauw first reported that total hemispherectomy could be carried out with beneficial results for infantile hemiplegia with uncontrollable convulsion, temper tantrum and mental deficiency. Hemispherectomy is not suitable for all cases of infantile hemiplegia, but is seems clear that it should be undertaken in any case of established infantile hemiplegia with fits which cannot be controlled by drugs, or in which there is backwardness or deterioration in the patient's intellectual or emotional state. We have recently experienced a 8-year-old boy who was suffering left hemiplegia with intractable epilepsy. Both carotid angiogram and pneumoencephalogram showed right cerebral hemiatrophy. After right hemispherectomy intractable seizure was controlled and personality disorder disappeared completely. But left hemiplegia wasn't definitely improved.
Cerebrum
;
Child
;
Epilepsy*
;
Hemiplegia*
;
Hemispherectomy*
;
Humans
;
Intellectual Disability
;
Male
;
Parturition
;
Personality Disorders
;
Seizures
8.Proposal of Modified HIL-indices for Determining Hemolysis, Icterus and Lipemia Interference on the Beckman Coulter AU5800 Automated Platform.
Laboratory Medicine Online 2017;7(2):66-72
BACKGROUND: The amount of interference due to hemolysis, bilirubin, and lipemia can be measured on the AU5800 autoanalyzer (Beckman Coulter, USA) by spectrophotometry. This is reported as semi-quantitative indices, specifically H-index, I-index, and L-index, respectively. In this study, we evaluated the impact of interference using chemistry assays and established the concentration of interfering substances and HIL-index above which analytically significant interference exists, according to CLSI guidelines C56-A and EP7-A2. METHODS: Pooled sera including different concentrations of analytes were prepared and mixed with hemoglobin, bilirubin, or Intralipid. These samples were then tested for 35 clinical chemistry analytes by AU5800 and the bias based on interferent concentrations was computed. The interferent concentration above which significant interference exists was calculated from the 50% within-subject biological variation (desirable analytic goal), and the corresponding index was assigned. RESULTS: Among 35 items evaluated, interference was detected for 12 analytes by hemoglobin, 7 analytes by bilirubin, and 12 analytes by Intralipid. We proposed HIL-index₁ and HIL-index₂ for each analyte according to 2 different medical decision levels. HIL-index₁ and HIL-index₂ were considered more reasonable criteria than the HIL-index from the manufacturer's technical document (HIL-index(TD)). This is because HIL-index(TD) was empirically set to 5% or 10%, and had a wide tolerance range, which was not sufficient to reflect the presence of interference, compared to HIL-index₁ and HIL-index₂. CONCLUSIONS: We have demonstrated hemoglobin, bilirubin, and Intralipid interferences according to CLSI guidelines using the desirable analytic goal. Our results provide applicable information for Beckman Coulter automated chemistry analyzers.
Bias (Epidemiology)
;
Bilirubin
;
Chemistry
;
Chemistry, Clinical
;
Hemolysis*
;
Hyperlipidemias*
;
Jaundice*
;
Spectrophotometry
9.Level of Emergency Medical care Required in Religious Mass Gathering.
Kwan Mo YANG ; Tae Wook KWON ; Du Young HWANG ; Hwan LEE ; Joo Il HWANG ; Se Kyung KIM
Journal of the Korean Society of Emergency Medicine 1997;8(2):179-184
STUDY OBJECTIVE: determine the level of medical care required for mass gatherings and describe the types of medical problems encountered in a religious mass gathered ceremony. DESIGN: Standard charts and a four-tiered triage system(minor, moderate, urgent, and emergent) were developed before the event. The triage system was applied to each chart retrospectively by a single emergency physician. SETTING: Medical staff(10 physicians,13 nurses,1 pharmacist, and 54 first-aid attendants) were based in 8 advanced life support (ALS) clinics. INTERVENTIONS: First-aid attendants referred patients to the clinics, where nurses conducted initial assessments and referred patients to physicians at the venue. Three ambulances were stationed at the venues. RESULT: 22 trauma patients were developed and 183 medical complaints were encountered. Only 7 urgent medical problems were encountered.
Ambulances
;
Emergencies*
;
Humans
;
Pharmacists
;
Retrospective Studies
;
Triage
10.Stomach Cancer Arising from Remmnant Stomach 14 Years after Gastrectomy of EGC Type I (m).
U Chang CHOI ; Kyung Hee KIM ; Kwan Sik LEE ; Young Myoung MOON ; Hy De LEE ; Hyeon Joo JEONG
Korean Journal of Gastrointestinal Endoscopy 1989;9(1):25-27
Recently therapeutic efficacy of stomach cancer was greatly improved due to early diagnosis and irnproved diagnostic and therapeutic modalities. Especially in early gastric cancer, 5 year survival rate is near 100%. Recarrence of early gastric cancer after curative surgery is rarely reported. Recently authors experienced one case of recurrent stomach cancer arising from remmnant stomach 14 years after gastrectomy of EGC type I(m), so we reports it here with review of literatures.
Early Diagnosis
;
Gastrectomy*
;
Stomach Neoplasms*
;
Stomach*
;
Survival Rate