1.Acute Toxic Hepatitis Caused by an Aloe Vera Preparation in a Young Patient: A Case Report with a Literature Review.
Jeonghun LEE ; Mi Sun LEE ; Kwan Woo NAM
The Korean Journal of Gastroenterology 2014;64(1):54-58
Aloe is one of the leading products used in phytomedicine. Several cases of aloe-induced toxic hepatitis have been reported in recent years. However, its toxicology has not yet been systematically described in the literature. A 21-year-old female patient was admitted to our hospital with acute hepatitis after taking an aloe vera preparation for four weeks. Her history, clinical manifestation, laboratory findings, and histological findings all led to the diagnosis of aloe vera-induced toxic hepatitis. We report herein on a case of acute toxic hepatitis induced by aloe vera.
Adult
;
Aged
;
Alanine Transaminase/blood
;
Alkaline Phosphatase/blood
;
Aloe/*chemistry/metabolism
;
Drug-Induced Liver Injury/*diagnosis/etiology/pathology
;
Female
;
Humans
;
Liver/pathology
;
Male
;
Middle Aged
;
Plant Extracts/*adverse effects/*chemistry
;
Splenomegaly/diagnosis
;
Tomography, X-Ray Computed
;
Young Adult
2.The Comparison of Histopathology of Cats Received Conventional Mechanical Ventilation and High Frequency Oscillation Ventilation.
Kwan Ho LEE ; Young Jo KIM ; Jae Chun CHUNG ; Hyun Woo LEE ; Hae Joo NAM ; Tae Sook LEE
Yeungnam University Journal of Medicine 1989;6(2):39-46
The tracheobronchial histopathologic findings in 7 healthy cats used with high frequency oscillation ventilation (HFOV) were compared with those in 6 cats used with conventional mechanical ventilation (CMV). 4-point, 9-variable scoring system was used to evaluate the injury in the trachea, right & left main bronchi and parenchyma. The following results were obtained; 1) The tracheobronchial tree received HFOV had no significant damage compared with CMV (P>0.05). 2) Intraepithelial mucus loss and emphysema were slightly more prominent in CMV groups. As above results; the tracheobronchial histopathologic difference was not prominent between CMV and HFOV groups received with relatively short period, however, the cellular of function and barotrauma may be more prominent in CMV groups. From now on, as causes of tracheobronchial injury in HFV, interaction between humidification and mechanical trauma considers further study.
Animals
;
Barotrauma
;
Bronchi
;
Cats*
;
Emphysema
;
High-Frequency Ventilation*
;
Mucus
;
Respiration, Artificial*
;
Trachea
;
Trees
3.Angiomyolipoma of the liver: a case report.
Yong Woo LEE ; Jae Chun CHANG ; Woo Mock BYUN ; Bok Hwan PARK ; Hong Jin KIM ; Moon Kwan JUNG ; Hey Joo NAM
Journal of the Korean Radiological Society 1993;29(3):475-479
Angiomyolipoma arising from the liver is a rare primary benign lipomatous tumor of the lever. We experienced a case of surgically proven hepatic angiomyolipoma, which was preoperatively diagnosed by definning of its characteristic histologic components and benign radiologic nature with various imaging modalities including ultrasound, dynamic computed tomography, angiography, and magnetic resonance imaging. It was the first reported case in the world that full radiologic evaluation was taken and internal vascular proliferation was defined by using dynamic bolus CT prior to angiography.
Angiography
;
Angiomyolipoma*
;
Liver*
;
Magnetic Resonance Imaging
;
Ultrasonography
4.Angiomyolipoma of the liver: a case report.
Yong Woo LEE ; Jae Chun CHANG ; Woo Mock BYUN ; Bok Hwan PARK ; Hong Jin KIM ; Moon Kwan JUNG ; Hey Joo NAM
Journal of the Korean Radiological Society 1993;29(3):475-479
Angiomyolipoma arising from the liver is a rare primary benign lipomatous tumor of the lever. We experienced a case of surgically proven hepatic angiomyolipoma, which was preoperatively diagnosed by definning of its characteristic histologic components and benign radiologic nature with various imaging modalities including ultrasound, dynamic computed tomography, angiography, and magnetic resonance imaging. It was the first reported case in the world that full radiologic evaluation was taken and internal vascular proliferation was defined by using dynamic bolus CT prior to angiography.
Angiography
;
Angiomyolipoma*
;
Liver*
;
Magnetic Resonance Imaging
;
Ultrasonography
5.Characteristics of the Posterior Aortic Wall Motions in M-mode Echocardiogram of the Patients with Various Valvular Heart Diseases.
Seung Kwan KIM ; Sang Jin PARK ; Kwang Woo NAM ; Myung Ho JEONG ; Young Gun YOON ; Jung Chaee KANG ; Ock Kyu PARK
Korean Circulation Journal 1985;15(4):587-593
To observe the characteristics of the posterior aortic wall motions of the patients with various valvular heart diseases the aortic root echocardiogram of the 60 patients with various valvular diseases were examined. 15 cases in each group of patients with mitral stenosis, mitral insufficiency, mitral stenoinsufficiency or aortic insufficiency. Thirty normal subjects were served as a control group. In each, the total amplitude of the aortic posterior wall motion(OV), the amplitude of the motion evented at atrial systole(AV), AV/OV ratio, atrial emptying index(AEI), left atrial and aortic root dimensions (LAD and AOD), and LAD/AOD were measured. The results were as follows ; 1) The AV was significantly increased in mitral stenosis(P<0.01) and decreased in mitral insufficiency(P<0.05) compared with control group. 2) The OV was increase in mitral insufficiency and aortic insufficiency(p<0.01, p<0.05), but decreased in mitral stenosis(p<0.05). 3) The AV/OV was increased in mitral stenosis(p<0.01) and decreased in mitral insufficiency and aortic insufficiency(p<0.01). 4) The AEI was decreased in all patient groups(p<0.01) and LAD was increase in all compared with control group(p<0.01). 5) The AOD was increased only in aortic insufficiency(p<0.01). 6) The LAD/AOD ratio was increased in all patient groups(p<0.01).
Heart Valve Diseases*
;
Humans
;
Mitral Valve Insufficiency
;
Mitral Valve Stenosis
6.A case of pseudomelanosis duodeni associated with chronic renal failure.
Jin Ho PARK ; Byeong Ik JANG ; Seung Ho KANG ; Tae Nyun KIM ; Moon Kwan CHUNG ; Hyun Woo LEE ; Hae Joo NAM
Korean Journal of Medicine 1993;45(4):538-542
No abstract available.
Kidney Failure, Chronic*
7.One Family of Familial Combined hyperlipidemia Associated with Various Metabolic Abnormalities.
Kwan Woo LEE ; Sung Kyu LEE ; Yun Suk CHUNG ; Hyun Man KIM ; Yoon Jung KIM ; Eun Kyung HONG ; Bong Nam CHAE ; Ji Won PARK
Journal of Korean Society of Endocrinology 1999;14(2):418-424
Familial combined hyperlipidemia is one af the manogenic disorders frequently found in humans and is seen in 0.5~2% of the general populatian, accounting for at least 10% of persons with pemature atlmmcletusis. The distinguishing feature of familial combined hyperlipidemia, in camparison with other single-gene abnarmalities of lipoprotein metabolism, is that not all affected members have the same plasma lipid phenotype; some individuals have an elevation of cholesterol concentration alane(type IIa lipoprotein pattern), while some athers have an elevation of triglyceride concentration alone(type IV pattem), and still others have elevations of both values(type IIb pattem). In any one persan, the lipid phenotype can change as a result of dietary or drug treatment. Familial combined hyperlipidemia should be suspected in those subjects with moderate hypertriglyceridemia and/or moderate hypercholestaolemia (lipoprotein types IIa, Ilb, IV), especially when premature coronary heart disease is evident in the family histary. Low plasma HDL-cholesterol, obesity, insulin resistance and hyperuricemia are often . Family members affected by familial combined hyperlipidemia should be identified and be treated, since tbe condition is associated with premature caronary heart diasease. We have found one family of familial combined hyperlipidemia with one member(case 1) associated with insulin resistance, hyperuricemia and gout, and another member(case 2) associated with diabetes mellitus and infertiTity.
Cholesterol
;
Coronary Disease
;
Diabetes Mellitus
;
Gout
;
Heart
;
Humans
;
Hyperlipidemia, Familial Combined*
;
Hypertriglyceridemia
;
Hyperuricemia
;
Insulin Resistance
;
Lipoproteins
;
Metabolism
;
Obesity
;
Phenotype
;
Plasma
;
Triglycerides
8.Effect of Coronary Collateral Circulation on Left Ventricular Function in Acute Myocardial Infarction.
Hyeon Seok NAM ; Jae Kwan SONG ; Kyu Hyung RYU ; Dae Won SOHN ; Byung Hee OH ; Young Bae PARK ; Yun Shik CHOI ; Jung Don SEO ; Young Woo LEE
Korean Circulation Journal 1988;18(3):329-335
To evaluate effect of coronary collateral circulation on left ventricular function in patients with acute myocardial infarction, global ejection fraction(EF), left ventricular end distolic pressure(LVEDP), peak creatine kinase(CK) level and regional wall motion were analysed and compared in 30 patients with acute myocardial infarction according to grade of coronary collateral circulation. Patients with total or near total(above 95% of diameter) occlsion of left anterior descending coronary artery without significant lesion in right coronary artery or left circumflex artery were selected and divided into 3 groups according to the degree of collateral circulation on coronary angiography, to be compared by the index of ejection fraction, peak creatine kinase level, left ventricular and diastolic pressure and regional wall motion. The result are as following : 1) There were no statistically significant differences in ejection fraction, peak creatine kinase level, left ventricualr and diastolic pressure among the groups. 2) Regional wall motion of infarct related area of G2+3 group(adequate collateral) were better than that of G0(no collateral) group(p<0.05). Therefore, adequate coronary collateral circulation in acute myocardial infarction is thought to have beneficial effect on left ventricular function especially in regional wall motion of infarct related area.
Arteries
;
Blood Pressure
;
Collateral Circulation*
;
Coronary Angiography
;
Coronary Vessels
;
Creatine
;
Creatine Kinase
;
Humans
;
Myocardial Infarction*
;
Ventricular Function, Left*
9.Antibody-dependent Cell-mediated Cytotoxitity as a Prognostic Indicator in the Medical Treatment of Graves' Disease.
Kwan Woo LEE ; Young Goo SHIN ; Hye Rim RO ; Sung Kyu LEE ; Yun Suk CHUNG ; Hyun Man KIM ; Yoon Jung KIM ; Eun Kyung HONG ; Bong Nam CHAE
Journal of Korean Society of Endocrinology 1998;13(4):554-562
BACKGROUND: The several forms of treatment of Graves disease-thyroidectomy, antithyroid drugs and radioiodide therapy-are in wide use now. But which therapy is best is a matter of debate. Some authors reported that in patients who underwent thyroidectomy, higher titers of serum antimicrosomal antibody were associated with 1) higher formation rates of germinal centers, 2) more lymphocyte infiltration in the thyroid tissue, 3) higher incidence of hypothyroidism, and 4) lower incidence of recurrence. We were interested in the relationship of thyroid autoantibody titers, ADCC(antibody-dependent cell-mediated cytotoxicity) activity and the clinical response to antithyroid medication. METHODS: We measured ADCC activities from patients in Graves disease(n-48), Hashimoto thyroiditis(n=17) and normal control(n=9). The patients of Graves disease were followed up for more than 1 year, and they were grouped into A(n=17, well responsed group to antithyroid medication) and B(n=31, poorly responsed group). We examined ADCC activities of patients' sera by chromium release assay. RESULTS: 1) Mean age of patients with Graves disease was 34.4210.4 years and 15 patients were male(31%). 2) Results of thyroid function tests of the Graves' patients were T 585.9 +/- 255.3 ng/dL, T4 21.3 +/- 12.2 mg/dL, TSH 0.11 +/- 0.06mIU/mL. Concentrations of antimicrosomal antibody, antithyroglobulin antibody and thyrotropin binding inhibitory immunoglobulin were 1279.1 +/- 1486.7 IU/mL, 488.1 +/- 751.1 IU/mL, and 38.5 +/- 33.4U/L respectively. 3) There was no significant difference between levels of thyroid hormones or concentrations of thyroid autoantibodies and ADCC activities in graves patients. 4) The ADCC activity of the Graves patient group(24.49%) was significantly higher than that of the normal control group(3.76%), and significantly lower than that of the Hashimotos thyroiditis group(36.34%). 5) There was no significant difference in ADCC activity between group A(18.24 +/- 13.44%) and B(27.91 +20.02%). CONCLUSION: From this results, we suggested that ADCC activity seems to be no value as a prognostic factor in predicting the response to antithyroid drugs in Graves disease patients. But, further studies, larger number of patients and long-term follow up, are needed.
Antibody-Dependent Cell Cytotoxicity
;
Antithyroid Agents
;
Autoantibodies
;
Chromium
;
Follow-Up Studies
;
Germinal Center
;
Graves Disease*
;
Humans
;
Hypothyroidism
;
Immunoglobulins
;
Incidence
;
Lymphocytes
;
Recurrence
;
Thyroid Function Tests
;
Thyroid Gland
;
Thyroid Hormones
;
Thyroidectomy
;
Thyroiditis
;
Thyrotropin
10.A Case of Bronchitis and Bronchial Dysplasia Associated with Typhoid Fever.
Jun Ho SEOK ; Ki Beom KIM ; Jin Hong CHUNG ; Kwan Ho LEE ; Hyun Woo LEE
Tuberculosis and Respiratory Diseases 1998;45(1):227-233
Typhoid fever is an acute systemic febrile disease caused by Salmonella typhi. The classic picture of the disease consists of prolonged continuous or remitting fever, abdominal pain, diarrhea, rose spots and delirium. Salmonella infection can lead to diffuse organ involvement, including bone, lung, thyroid, kidney, liver, spleen, heart, pericardium, intestine and skin and cause a variety of complications. Pulmonary manifestations occur in only 1 percent of the patients. Mild cough with sticky sputum is the earliest symptom and bronchitis, pneumonia and lung abscess were presented. Recenfly we experienced a case of typhoid fever complicated by bronchitis, dysplasia in a 37-year-old male physician who was improved with ceftriaxone and ciprofloxacin We report this case with a review of the literature.
Abdominal Pain
;
Adult
;
Bronchitis*
;
Ceftriaxone
;
Ciprofloxacin
;
Cough
;
Delirium
;
Diarrhea
;
Fever
;
Heart
;
Humans
;
Intestines
;
Kidney
;
Liver
;
Lung
;
Lung Abscess
;
Male
;
Pericardium
;
Pneumonia
;
Salmonella Infections
;
Salmonella typhi
;
Skin
;
Spleen
;
Sputum
;
Thyroid Gland
;
Typhoid Fever*