No abstract available in English.
Electric Stimulation

We performed a clinical study of the effect of electrical current on the congenital pseudarthrosis of the tibia from May, 1980 to January, 1984. Eight congenital pseudarthrosis were treated with direct current stimulation, six of which had received previous treatment at least more than one time in any manner and two had none. Four were failures in previous treatment with vascularized fibular graft due to the non-uoion at the proximal or distal sites of grafted bones. Six of eight congenital pseudarthrosis were treated with invasive type electrical stimulators, and the remaining two were treated with semi-invasive type. The average follow-up period was 26 months (range from 8 to 39 months). As a result satisfactory union has occured in seven out of eight cases. The mean time for union was 27 weeks (range from 15 weeks to 48 weeks). No serious complication was observed, but in our experience, the semi-invasive type, comparing to invasive type, was handicaped with minor complications such as pin tract infection and skin sloughing due to the irritation by anode pad, and needed frequent recharging to maintain adequate voltage. With above result, we think that the electrical stimulation has revealed to be one of the reliable methods in the treatment of surgery-resistant congenital pseudarthrosis.
Clinical Study ; Electric Stimulation ; Electrodes ; Follow-Up Studies ; Pseudarthrosis ; Skin ; Tibia ; Transplants

Colorectal cancer is the second most frequent malignant tumor in the United States and fourth most frequent tumor in Korea. Surgery has been used as a primary treatment modality but reported overall survivals after curative resection were from 20% to 50%. Local recurrence is the most common failure in the treatment of locally advanced colorectal cancer. Once recurrence has developed, surgery has rarely the role and the five year survival of locally advanced rectal cancer is less than 5%, this indicated that significant improvement of local conrol could be achieved. We performed 6 cases of IORT for locally advanced colorectal cancer which is he first experience in Korea. Patient's eligibility, treatment applicator, electron energy, dose distribution on the surface and depth within the treatment field and detailed skills are discussed. We hope that our IORT protocol can reduce local failure and increase the long term survival significantly.
Colorectal Neoplasms* ; Hope ; Korea ; Radiotherapy* ; Rectal Neoplasms ; Recurrence ; United States

Local control is the important prognostic factor in cancer treatment because local control decrease the relative risk of metastatic spread and increse distant metastasis free survival. IORT is the modality which could increase local control without incressing complication, combined with curative operation. Eventhough we could achieve significant deacreased local failure by IORT and curative resection, it should not be committed as a main treatment modality without proving acceptable complications. Therapeutic Radiology Department of Yeungnam University Medical Center have tried 58 IORT from June 15, 1988, and performed 53 IORT in patients with gastric cancer. No local failure has been reporte? by regular follow up so far. Nine cases(17%) of treatment related complifaiton were reported including intestinal obstrution, hemorrhage, sepsis, and bone marrow depression. These complications could be comparable to Jo's 25.2% (chemotherapy + operation), Kim's 18% (chemotherapy only in inoperable patients), because our treatment regimen is consisted of IORT (1500 cGy), external irradiation(--4500 cGy) and extensive chemotherapy (FAM, 5FU+MMC, BACOP). Our data encouraged us to re-inforce further IORT in stomach cancer treatment.
Academic Medical Centers ; Bone Marrow ; Depression ; Drug Therapy ; Follow-Up Studies ; Hemorrhage ; Humans ; Neoplasm Metastasis ; Radiation Oncology ; Sepsis ; Stomach Neoplasms*

PURPOSE: The purpose of this study was to evaluate the clinical usefulness of chest high-resolution computed tomography(HRCT) in patients with chronic coughs or persistent wheezing with normal chest X-ray finding. METHODS: We reviewed the charts, chest X-rays, and HRCT findings of patients with chronic coughs or persistent wheezing of less than 2 years of age. The records were sourced from the Department of Pediatrics, Inha University Hospital covering the period from July, 1999 to June, 2000. Chronic cough was defined as a cough which was prolonged for more than 3 weeks. RESULTS: The sample consisted of 24 patients(male 15 and female 9, mean age 4.7+/-3.8 months old). Among them, 16 patients showed normal findings(66.7%) and 8 patients showed abnormal (33.3%) in simple chest X-rays. Among 16 patients who had the normal chest X-rays, 13 patients showed abnormal chest HRCT findings(81.3%) such as air space consolidation of the dependent portion(62.5%), bronchiolitis obliterans(12.5%), and bronchopulmonary dysplasia(6.3%). CONCLUSION: We suggest that the chest HRCT is a useful diagnostic tool in the evaluation of patients with chronic cough or persistent wheezing with normal chest X-ray, especially below 2 years of age.
Bronchiolitis ; Cough* ; Female ; Humans ; Pediatrics ; Respiratory Sounds ; Thorax*

PURPOSE: Carbon monoxide (CO) may mediate smooth muscle relaxation in the rat corpus cavernosum smooth muscle (CCSM). We hypothesized that CO plays a role in neurally derived, frequency-dependent relaxation of rat CCSM. MATERIALS AND METHODS: To study the effect of CO on CCSM relaxation induced by electrical field stimulation (EFS), a CCSM bundle was mounted on a force transducer and perfused with Hanks' balanced salt solution at 37degrees C with 95% O2 and 5% CO2. After 1 hour equilibration with -500 mg of passive tension, contraction of the CCSM bundle was elicited by 10(-5) M phenylephrine, which was continuously added with different concentrations of CO (1%, 2%, and 5%). Frequency-dependent relaxation was induced by EFS trains (0.2 ms at 0.5-32 Hz, for 10 s) repeated at 2 min intervals over 15 min in the presence of adrenergic and muscarinic receptor blocking agents (guanethidine and atropine, respectively). To study the distribution of heme oxygenase-2 (HO-2) in the rat CCSM, we performed immunohistochemical evaluation. RESULTS: CO produced a dose-dependent enhancement of EFS-induced relaxation. Pretreatment with N(G)-nitro-L-arginine (a nitric oxide synthase blocker) greatly reduced the EFS-induced relaxation in the presence of CO (-45%). Pretreatment with zinc protoporphyrin-IX (ZnPP-9, a heme oxygenase inhibitor) had no significant effect on EFS-induced relaxation in the absence or the presence of CO. We found immunoreactivity for HO-2 in CCSM and immunoreactivity for protein gene product 9.5 (PGP 9.5) in nerve fibers. CONCLUSIONS: We conclude that CO produced a dose-dependent enhancement of EFS-induced relaxation in rat CCSM bundles, but neurally derived, frequency-dependent relaxation in the rat CCSM depended mostly on nitric oxide in response to nonadrenergic noncholinergic neurotransmission. Immunoreactivity for HO-2 was found in rat CCSM but not nerve fibers.
Animals ; Atropine ; Carbon ; Carbon Monoxide ; Contracts ; Cyclic GMP ; Electric Stimulation ; Heme ; Heme Oxygenase (Decyclizing) ; Isotonic Solutions ; Male ; Muscle Relaxation ; Muscle, Smooth ; Nerve Fibers ; Nitric Oxide ; Nitric Oxide Synthase ; Penile Erection ; Phenylephrine ; Rats ; Receptors, Muscarinic ; Relaxation ; Synaptic Transmission ; Transducers ; Zinc

Penile fracture is known as a rupture of the tunica albuginea occurring during erection. Diagnosing a penile fracture is usually not difficult, and often is based on the patients history and a physical examination. However, patients with atypical clinical findings may require an accurate diagnostic procedure. Immediate surgical intervention is normally used for treating a penile fracture due to the high risk of complications associated with conservative management. The authors recently experienced 2 cases of a penile fracture and the superiority of magnetic resonance imaging (MRI) over ultrasonographic imaging for diagnosing a suspected penile fracture was shown. Therefore, MRI is recommended for diagnosing a suspected atypical penile fracture.
Diagnosis* ; Humans ; Magnetic Resonance Imaging* ; Male ; Penis ; Physical Examination ; Rupture

We present a case of recurrent left atrial myxoma which occurred 7 years and 10 months after initial operation despite resection of originaltumor and adjacent atrial septum. This is the first case report of recurrence in Korea. Among the possible causes of recurrence, regrowth from pretumorous focus seems to be the most suggesting one in this case. Histopathologic findings of recurrent myxoma showed increased cellularity with active proliferation and nuclear hyperchromasia. These findings, together with the rapidity of regrowth, suggest that recurrent myxoma may have 'wilder' behavior. Prolonged postoperative observation is important, even if ample resection was done at the initial operation including atrial septum.
Atrial Septum ; Korea ; Myxoma* ; Recurrence*

Total 28 patients with respectable, locally advanced gastric cancer were entered in our prospective randomized study from June 15, 1988 to Sep. 15, 1990 in Yeungnam University Hospital. This study consisted of curative resection, IORT, external irradiation and combination of chemotherapy. Twenty-four of 28 patients were treated with single dose of 1500 cGy per fraction, 5 days per week was started within 4th weeks postoperative days. Various chemotherapy with or without external irradiation were added for reducing hematogenous and/or peritoneal dissemination and determination of complication of each arm. Duration of follow up was 4~31 months. No serious complication related with radiation were reported compare to resection and chemotherapy only group. Although our follow up period is too short to draw any conclusion, IORT appears to improve local control, hopely further survival. Continuous follow up should be needed for evaluation of real therapeutic gain such as complication vs. improved survival.
Arm ; Drug Therapy ; Follow-Up Studies ; Hope ; Humans ; Prospective Studies ; Stomach Neoplasms*

No abstract available.
Puberty, Precocious* ; Sertoli-Leydig Cell Tumor*