Ear reconstruction with conventional modalities necessitates time consumming, expenses and multi-stage operations, a lot of time, and cost. Although single stage ear reconstruction with vascularized temporoparietal fascia has been developed, it is not always suitable due to precious surgery or trauma. Recently, prefabrication of a secondary island flap by transferring axial vessels and revascularizing target tissues has been attempted. The prefabricated composite secondary island flap can be transferred to other sites by micro-vascular anastomoses of the axial vessels in a second stage operation. In 10 rabbits, a 5x11cm sized bipedicled abdominal flap including panniculus carnosus muscle, concomitantly pedicled on the superficial inferior epigastric vessels was elevated. A 2.5x4cm sired auricular cartilage carried in the shape of a human auricle was tacked on the inner surface of the flap, and the flap was tubed with 4-0 nylon sutures. The abdominal donor wound was primarily closed. At 17 days after elevation, the tubed abdominal flap was trimmed into a human ear shaped composite island flap connected only by the superficial epigastric vascular bundles, and the caudal pole was sutured back to the abdominal skin. Skin surface fluorometry was performed to assess the degree of skin perfusion. The percentage of skin flap survival was recorded 14 days later. The mean Dye Fluorescence Index was 68 14% of normal. Almost 100% of the skin was survived in all rabbits. The histologic study revealed infiltration of homogeneous granulation tissue between the cartilage and flap. The grafted cartilage was healthy and showed normal appearance. Using this principal of ear prefabrication through delay and revascularization of various tissues as an island composite flap, it can be applied in humans with scaring of the temporo-parietal region.
Cartilage* ; Ear ; Ear Cartilage ; Fascia ; Fluorescence ; Fluorometry ; Granulation Tissue ; Humans ; Nylons ; Perfusion ; Rabbits ; Skin ; Sutures ; Tissue Donors ; Transplants ; Wounds and Injuries

No abstract available.
Hand* ; Tendons* ; Transplants*

No abstract available.

The objective of this study was to clarify the different inhibitory effects against necrosis according to the injection time of hydrocortisone on adriamycin extravasated wounds. The extravasation of chemotherapeutic agents yields severe inflammatory responses, crust formation, skin necrosis, and ulceration. Thus, many studies on the prevention and alleviation of this tissue injury have been made. However, a comparative study on the inhibitory effect of antidots according to the injection time after extravasation of chemotherapeutic agents has not yet been made. We compared the effect of hydrocortisone succinate on adriamycin-induced tissue necrosis according to its injection time. Sixty mature male Sprague-Dawley rats were divided into 6 groups and each group contained 10 rats. Administration of adriamycin(1.0mg/ml) 0.5ml by subcutaneous injection on the dorsal side of the rats was followed by injection of hydrocortisone succinate(20mg/ml) 0.5ml on the same site according to a time protocol. Group 1(the co-ntrol group): adriamycin injection only; gorup 2(the normal saline group): injection of normal saline 30 minutes after adriamycin injection; group 3: injection of hydrocortisone 30 minutes after adriamycin injection; group 4: injection of hydrocortisone 6 hours after adriamycin injection; group 5: injection of hydrocortisone one day after adriamycin injection; group 6: injection of hydrocortisone 3 days after adriamycin injection. Mean areas of ulcer, measured in mm2, which developed 4 week after adriamycin injection were as follows; group 1 (the control group): 67.3; group 2(the normal saline group):44.8; group 3: 12.9; group 4: 18.9; group 5: 46.7; group 6:72.0. Significant differences among the groups were noted. The groups which received hydrocortisone injection showed smaller ulcers compared to the control group or the normal saline group. As well, earlier injection time correlated with smaller ulcer formation. These findings showed the inhibitory effect of hydrocortisone succinate on tissue damage caused by adriamycin, as well as the increased effectiveness of the inhibitory effect when earlier injections were made. An analysis of this study can be applied in clinical situations for extravasation of adriamycin by administering proper agents such as hydrocortisone succinate. The administration of these agents will also help to minimize tissue necrosis.
Animals ; Doxorubicin ; Humans ; Hydrocortisone* ; Injections, Subcutaneous ; Male ; Necrosis* ; Rats ; Rats, Sprague-Dawley ; Skin ; Succinic Acid ; Ulcer ; Wounds and Injuries

No abstract available.
Carcinoma*

No abstract available.
Lower Extremity* ; Melanoma*

No abstract available.
Cleft Lip*

No abstract available.
Free Tissue Flaps* ; Neck*

No abstract available.
Surgical Flaps*

No abstract available.
Syndactyly*