Through reviewing domestic and foreign literature on augmentative and alternative communication in patients with motor neuron disease,this paper summarized the characteristics of communication disorders in patients with motor neuron disease,the effect caused by poor communication,as well as the application of augmentative and alternative communication. The purpose of this study is to provide an appropriate augmentative and alternative communication system for patients with motor neuron disease with communication disorders,so as to improve the quality of life of patients,improve negative psychological emotions,and reduce the burden of caregivers.