1.From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor-1 expression in cancers.
Fariz NURWIDYA ; Fumiyuki TAKAHASHI ; Kunihiko MINAKATA ; Akiko MURAKAMI ; Kazuhisa TAKAHASHI
Anatomy & Cell Biology 2012;45(2):73-78
Hypoxia, defined as a decrease of tissue oxygen levels, represents a fundamental pathophysiological condition in the microenvironment of solid tumors. Tumor hypoxia is known to be associated with radio/chemo-resistance and metastasis that eventually lead to cancer progression contributing to poor prognosis in cancer patients. Among transcription factors that accumulated under hypoxic conditions, hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that has received the most intense attention in this field of research due to its capacity to modulate several hundred genes. With a clearer understanding of the HIF-1 pathway, efforts are directed at manipulation of this complex genetic process in order to ultimately decrease cellular HIF-1 levels. Some novel agents have been shown to have HIF-1 inhibition activity through a variety of molecular mechanisms and have provided promising results in the preclinical setting.
Anoxia
;
Genetic Processes
;
Humans
;
Neoplasm Metastasis
;
Oxygen
;
Prognosis
;
Transcription Factors
2.From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor-1 expression in cancers.
Fariz NURWIDYA ; Fumiyuki TAKAHASHI ; Kunihiko MINAKATA ; Akiko MURAKAMI ; Kazuhisa TAKAHASHI
Anatomy & Cell Biology 2012;45(2):73-78
Hypoxia, defined as a decrease of tissue oxygen levels, represents a fundamental pathophysiological condition in the microenvironment of solid tumors. Tumor hypoxia is known to be associated with radio/chemo-resistance and metastasis that eventually lead to cancer progression contributing to poor prognosis in cancer patients. Among transcription factors that accumulated under hypoxic conditions, hypoxia-inducible factor-1 (HIF-1) is a master transcription factor that has received the most intense attention in this field of research due to its capacity to modulate several hundred genes. With a clearer understanding of the HIF-1 pathway, efforts are directed at manipulation of this complex genetic process in order to ultimately decrease cellular HIF-1 levels. Some novel agents have been shown to have HIF-1 inhibition activity through a variety of molecular mechanisms and have provided promising results in the preclinical setting.
Anoxia
;
Genetic Processes
;
Humans
;
Neoplasm Metastasis
;
Oxygen
;
Prognosis
;
Transcription Factors
Result Analysis
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