1.QUANTITIVE AND QUALITATIVE STUDIES ON TISSUE TRIGLYCERIDE IN AGING OF RATS
SUKETSUNE IWAGAKI ; KEIZO KOBAYASHI ; KUNIHIKO HARADA ; MANABU YAMADA ; TOSHIO SAKAI
Japanese Journal of Physical Fitness and Sports Medicine 1980;29(2):110-116
Triglyceride contents of liver, heart muscle and skeletal muscles (rectus femoris, tibiaris anterior, soleus, plantaris and extensir digitrum longus) were determined on 1, 3.5, 14, 18 and 21 months-old rats, and especially on 14 and 21 months-old rats composition of triglyceride fatty acids was analyzed and interrelation of these triglyceride contents with aging of rats was studied quantitively and qualitatively. Following results were obtained
1) Changs in liver and muscular triglyceride contents appeared on 14 months-old rats and were significant increase at 21 months-old rats.
2) Liver triglyceride content significantly decreased at 21 months-old rats (p<0.05) .
3) lrriglyceride contents of tibiaris anterior and extensor digitrum longus muscles were mostly unchangeable through the aging of rats.
4) But triglyceride contents of soleus, rectus femoris and plantaris muscles in 21 months-old rats significantly increased (p<0.05) and the individual difference was great.
5) In composition of triglyceride fatty acids, increase of C18, C18-1, C18-2 and C18-3 was observed in epididymal adipose tissue, soleus and rectus femoris muscle on 21 months-old rats, but in extensor digitrum longus and tibiaris anterior muscles.
From these results, changes of tissue triglyceride contents with aging of rats are different in each tissue and increase of triglyceride content is present with qualitative changes in composition of triglyceride fatty acids, increase of long chain and unsaturated fatty acids, and organic specificity, which is related to the functional changes with aging of rats is considered.
4.STUDY ON THE ERROR THAT WAS ACCOMPANIED WITH BODY GIRTH
MITSUTSUGU ONO ; MOTOKO KOBAYASHI ; TERUO KAISE ; KAZUKO NAKAGAWA ; TAKAHIRA NOMURA ; MICHIAKI IKEDA ; HILOSHI KURATA ; AKIHITO YANAGIMOTO ; KUNIHIKO HARADA ; TERUYA AMAMIYA
Japanese Journal of Physical Fitness and Sports Medicine 1971;20(3):159-168
10 male and 8 female skillful tester on physical fitness measurements were attended. They were measured one another the body girth and blood pressure of themselves. The result obtained on the same person by the different tester were not always coincident. The following issues were obtained.
(1) Mean value of individual error finding on the systolic pressure was about 4mmHg, on the diastolic pressure was about 6mmHg. Mean value of the difference between the maximum and minimum value of the systolic pressure reported on the same person was 15.4mmHg in male group. That of the diastolic value was 21.4mmHg in male group. For the female group, that of the systolic pressure was 17.0mmHg, that of the diastolic pressure was 23.0mmHg.
(2) Mean value of individual error (as under, be showed by“error”) obtained on the chest girth was 1.43cm in male group, 1.05cm in female group. Mean value of the difference between the maximum and minimum value (as under, be showed by“breadth”) was 5.99cm in male, 4.08cm in female.
(3) “Error”observed on the overarm extended girth was 0.73cm in male, 0.79 cm in female, “breadth”was 2.96cm in male, 2.99cm in female.
(4) “Error”finding on the overarm flexed girth was 0.60cm for both sex, “breadth”was 2.81cm in male, 2.43cm in female.
(5) For the forearm girth, “Error”was 0.40cm in male. 0.24cm in female, “breadth”was 1.81cm in male, was 1.35cm in female.
(6) For the thigh girth, “Error”was 0.90cm in male, 0.69cm in female, “breadth”was 3.91cm in male, 2.93cm in female.
(7) On the calf girth measurement, in male and female group, “Error”was 0.44 and 0.40cm, “breadth”was 1.51 and 1.48cm respectively.
From above mentioned findings, we considered that“Error”is possible to regard as unavoidable error, “breadth”might be probable error.
5.Intralobar Nephroblastomatosis Mimicking Wilms Tumor Treated with Chemotherapy after Removal of the Affected Kidney
Hirozumi SANO ; Ryoji KOBAYASHI ; Satoru MATSUSHIMA ; Daiki HORI ; Masato YANAGI ; Daisuke SUZUKI ; Go OHBA ; Hiroshi YAMAMOTO ; Kunihiko KOBAYASHI
Clinical Pediatric Hematology-Oncology 2023;30(1):21-24
Nephroblastomatosis (NBM) is a precursor of Wilms tumor. We herein report a case in which Wilms tumor was initially suspected and the affected kidney was removed.The tumor was subsequently diagnosed as intralobar NBM and a favorable outcome was achieved with postoperative chemotherapy. A 2-year-old boy who presented with gross hematuria was found to have an enlarged left kidney with hydronephrosis.Needle biopsy of the left kidney suggested Wilms tumor and left nephrectomy was performed. The tumor was histopathologically diagnosed as intralobar NBM.Although NBM is regarded as a precancerous lesion, a definite treatment plan has not yet been established. In the present case, we used a similar chemotherapy regimen to that for Wilms tumor. Eight years after the completion of chemotherapy, Wilms tumor has not developed or recurred. Appropriate management plans need to be developed by accumulating similar cases.
6.Comparison of the Efficacy of Piperacillin/Tazobactam and Meropenem, with or without Intravenous Immunoglobulin, as Second-Line Therapy for Febrile Neutropenia: A Prospective, Randomized Study
Hirozumi SANO ; Ryoji KOBAYASHI ; Satoru MATSUSHIMA ; Daiki HORI ; Masato YANAGI ; Koya KODAMA ; Daisuke SUZUKI ; Kunihiko KOBAYASHI
Clinical Pediatric Hematology-Oncology 2021;28(2):75-83
Background:
Febrile neutropenia (FN) remains an important complication in pediatric cancer patients. The present study compared the efficacy of meropenem (MEPM) and piperacillin/tazobactam (PIPC/TAZ) with or without intravenous immunoglobulin (IVIG) as second-line therapy for FN in pediatric patients.
Methods:
As first-line treatment for FN, 394 episodes in 99 patients were randomly assigned to receive PIPC/TAZ (360 mg/kg/day, maximum 18 g/day) or MEPM (120 mg/ kg/day, maximum 3 g/day). Eighty-four episodes in 42 patients were judged as failures, and, thus, were enrolled for second-line treatment. In second-line treatment, antibiotics were switched to MEPM or PIPC/TAZ, and episodes were further randomized for treatment with or without concomitant IVIG at 100 mg/kg/day (maximum 5 g/day) for 3 consecutive days.
Results:
The total success rate of second-line treatment was 50.0% (52.0% in PIPC/ TAZ and 47.2% in MEPM with or without IVIG, P=0.826). The success rates of patients treated with (IVIG+ group) and without IVIG (IVIG− group) were 53.8 and 46.7%, respectively (P=0.662). In the IVIG+ group, the success rate of patients younger than 8 years old was 78.6%, which was significantly higher than that of those aged 8 years and older (40.0%, P=0.043).
Conclusion
PIPC/TAZ and MEPM were equally effective as second-line treatment. Concomitant IVIG was also effective, particularly in patients younger than 8 years.