Introduction: Recently, ointment bases have been considered to play more important roles in wound healing than those played by their main agents. There has been an increasing interest in the use of macrogol (MAC) because it is considered to accelerate the epithelialization of pressure ulcers. We compared the effectiveness of MAC and vaseline (VAS) in healing d2 (partial-thickness skin loss) sacral pressure ulcers.Methods: Twenty-five cases of d2 sacral pressure ulcers, which occurred in patients in long-term-care beds in our hospital, were initially included in this study. VAS was applied to d2 sacral pressure ulcers in 13 cases (VAS group), and MAC was also applied in 12 cases (MAC group). After VAS or MAC was applied, all pressure ulcers were covered with non-adhesive, water-absorbing gauzes. One case of in-hospital mortality was excluded from the MAC group; therefore, 13 cases in the VAS group and 11 cases in the MAC group were included in the final analysis. The healing periods were compared between the two groups.Results: There were no significant differences in the patients' background between the two groups. The healing period (days) in the MAC group (8 [7-11.5]) was significantly shorter than that in the VAS group (16 [12-32]) (P=0.029).Conclusion: MAC may accelerates the healing process of d2 sacral pressure ulcers.