Bronchopulmonary dysplasia (BPD) is one of the most common serious chronic respiratory diseases in premature infants.In recent years,BPD has been significantly increasing with the improved survival rate of extremely preterm babies.About 10％ of neonates with mechanical ventilation might suffer from BPD,and this may lead to a great burden and costs to both the family and the society.A variety of risk factors has been proposed to be associated with BPD in preterm infants.However recent abroad researches indicated that genetic factors might predispose to BPD of preterm neonates,and initial results of domestic related researches inferred that several susceptibility genes might contribute to BPD development in Han preterm infants.This review focuses on recent publications related to genetic factors that may potentially contribute to BPD.

Coordinated care delivery is faced with various challenges to carry out in China,which are major decisions to make for decision makers,including how to push forward,how to deliver resources, services and patients to primary institutions,and how to ease the difficulties and affordability of seeing doctors.Based on analysis of roadblocks in coordinated care delivery in China,the authors provided near-term and long-term policy recommendations on the system,including how to build a scientific and reasonable healthcare delivery system,coordinated care delivery by stages,building incentives and constraint mechanisms,and enhancing public awareness and patient-doctor education.

Concept of coordinated care delivery is clearly defined,before a comparative analysis is made between such a concept and the integrated care delivery concept which is popular overseas and similar.On such basis,a theory framework is established for building and implementing such care delivery in line with the integrated theory of care delivery systems.Coordinated care delivery system now in place in China aims at rationally delivering medical resources,services and patients to primary institutions,by means of efficiently distributing resources and service systems and integrating care delivery flows,thus offering patients with cost effective and appropriate services and optimizing the care delivery system.

Enterovirus 71(EV71),a member of human enterovirus family,was first isolated from faeces of a central nervous system infected infant in 1969.In recent 30 years,EV71 outbreaks every 2-3 years in the Asia-Pacific regions,and is the main pathogen causing severe hand-foot-mouth disease(HFMD).Severe HFMD caused by EV71 involves in central nervous system and respiratory system disorder.In general,EV71 associated complication is related to the viral invasion of central nervous system,leads to pulmonary edema or pulmonary hemorrhage.It is of great significance to study the clinical features and pathogenesis of EV71 infection,and then take positive and effective measures to block the occurrence of its complications.

Hydronephrosis is one of the most common urological diseases in children.Most of hydronephrosis caused by ureteropelvic junction obstruction.Whether these children need operations were being argued.The current tendency is when the renal function become worse,operation is suggested needed,in order to save the renal function.So the methods how to evaluate the renal function are especially important,this article related to the current research and review.

Antiviral Agents ; therapeutic use ; Child ; Deoxyribonuclease (Pyrimidine Dimer) ; therapeutic use ; Humans ; Immunization, Passive ; Infant ; Picornaviridae Infections ; drug therapy ; therapy ; Respiratory Syncytial Virus Infections ; drug therapy ; therapy ; Ribavirin ; therapeutic use

Analyzed in the paper is the present development of medical rehabilitation service system in Beijing,Changsha,and Urumqi,in an effort to identify key measures,and discover problems found with the policy environment and system building.Based on such findings,the authors proposed such measures as developing policies and regulations, optimizing resource allocation, strengthening training of rehabilitation personnel and greater publicity.

Rhoptry proteins are the major virulence factors of Toxoplasma gondii. They locate in different parts of the host cells and can affect the membrane cytoskeleton structure and active factors of the host cells so as to block the cell intrinsic de-fense mechanisms of the host and let T. gondii invade parasitize and proliferate in the host successfully. The function and ac-tion mode of rhoptry proteins reflect the pathogenic mechanism of T. gondii which holds great significance to looking for toxo-plasmosis drug targets and developing molecule vaccines. This paper reviews the research progess of the interaction between rhoptry proteins of T. gondii and host cells.

Abstract Treating different diseases with same method and treating same disease with different methods have profound theoretical origins as an important content of TCM syndrome differentiation and treatment system.This theory is introduced into studies of TCM prevention and treatment of fibrosis and sclerosis of the liver,kidney.lung and other organs to search for effective drugs for common treatment of multiple organ fibrosis.so as to reveal the essenee of fibrosis and sclerosis of organs and open a new way for TCM prevention and treatment of refractory diseases;to provide experimental basis for TCM theory of treating different diseases with same method and treating same disease with different methods,and to provide new thinking and new method for studies of integrated western and Chinese medicine,TCM modernization and standardization.

AIM To study the effects of vitamin E succinate (VES) on the cell growth and the DNA synthesis of human gastric carcinoma cell (SGC 7901). METHODS The growth curve was determined with counting viable cell numbers. The colony formations were counted with Giemsa dye staining. The cell cycle was analyzed using flow cytometry (FCM) and the DNA synthesis was observed with the 3H TdR incorporation method. RESULTS VES could inhibit the growth and colony formation of SGC 7901 cells. Growth curve display:after SGC 7901 cells were treated with 5 mg?L -1 、10 mg?L -1 and 20 mg?L -1 VES for seven days, the inhibition rate are 41 2%、98 3% and 100%, respectively. The colony formation of SGC 7901 cell at 24 h was inhibited 6 7%、50 4%、87 2%, and at 48 h was 24 7%、73 4%、100%, respectively. FCM analysis revealed that VES could decrease the percentage of cells in G 2 M phase after treated 48 h in a dose dependent manner, while increase the percentage of cells in S pheise. The assays of 3H TdR incorporation into DNA showed obvious inhibition dose dependently after exposure to VES for 48 h. CONCLUSION VES could inhibit gastric carcinoma cell growth by arresting DNA synthesis in vitro .