Objective To investigate the role of new contrast agent and real time gray scale contrast tuned imaging in the evaluation of the perfusion and echogenicity of liver neoplasms and to discuss the diagnostic value.Methods Thirty five patients with unconfirmed liver neoplasms were enrolled in the study.Nine of them were diagnosed clinically,while the other 26 cases with pathological evidence through surgery or needle biopsy.Contrast agent SonoVue,Technos DU6 and CnTI technology were used.The contrast agents were delivered intravenously or through bolus injection.Results Timing of all phases following contrast injection in normal and cirrhotic liver was observed.And then the perfusion processs of liver neoplasms was recorded.Among the 23 cases of typical hepatocellular carcinoma(HCC),21 cases(91%) presented with early artery enhancement and immediate wash out,while the other 2 cases of small(

Through the questionnaire survey of 2,000 patients with dysmenorrhea, the clinical characteristics of dysmenorrhea were investigated, and the reference basis for preventing and controlling dysmenorrhea was provided. The results found that the age of menarche, short menstrual cycle, by volume, long period of time has no obvious relationship with the occurrence of dysmenorrhea. Dysmenorrhea main influence factors to feel cold; syndrome (symptoms) characteristics for the actual situation inclusions mainly, with severity, deficiency symptoms more obvious; in different degrees of dysmenorrhea, frequency of belly chills symptoms appear most, and cold coagulation and blood stasis syndrome (symptoms) appear higher frequency; The type of cold coagulation and blood stasis dysmenorrhea was 53.2%. Dysmenorrhea measures to select bed rest most, accounting for 79.6%. For severe dysmenorrhea in patients with drug choice to traditional Chinese combined with western medicine accounted for 43.4%. Selection of Chinese medicine formulations in patients with dysmenorrhea Decoction formulation accounted for the most 26.5%. The survey results, to avoid cold and have a positive effect on the prevention of dysmenorrhea, dysmenorrhea treatment should pay attention to warming channels to dispel cold.
Adolescent ; Adult ; Child ; China ; epidemiology ; Drugs, Chinese Herbal ; administration & dosage ; Dysmenorrhea ; diagnosis ; drug therapy ; epidemiology ; Female ; Humans ; Middle Aged ; Surveys and Questionnaires ; Young Adult

Dingkun Dan is a representative of the classic gynecological medicine. With Tonifying the liver and kidney, supplementing Qi and nourishing blood, regulating menstruation Shuyu, promoting the role of pain. Used in treatment of liver and kidney deficiency, deficiency of both qi and blood, Qi stagnation and blood stasis caused by irregular menstruation, menstrual pain, uterine bleeding, leukorrhea with reddish discharge, bruise blood removal, infertility, and various postpartum deficiency and bone steaming hot flashes of gynecological common disease. In recent years, Dingkun Dan's new uses have been reported, the clinical application value is worth further digging. In this paper, clinical application and research progress of Dingkun Dan since the founding of new China were briefly discussed, and summarize for the randomized controlled trials.
China ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Infertility, Female ; drug therapy ; physiopathology ; Kidney ; drug effects ; physiopathology ; Liver ; drug effects ; physiopathology ; Menstruation ; drug effects ; Randomized Controlled Trials as Topic

Perimenopausal syndrome refers to a series of physical and mental symptoms ,caused by the fluctuation of the sex hormones in the menopause, which is one of the common diseases in gynecology. With the acceleration of the aging population ir the world, it has caused the world's attention. Modern medicine has developed rapidly in the field of basic theory and clinical research, but there are still some problems in the treatment. Clinical treatment is mainly in hormone replacement therapy, but there are some potential risks, adverse reactions and many contraindications, thereby reducing patients' compliance and tolerance. Traditional Chinese medicine under the guidance of the concept of wholism cure perimenopausal syndrome based on syndrome differentiation, which has unique advantages, such as a variety of ways, less side effect, curative effect, which was patients more and more welcome. It is very important for the study to explore the perimenopausal syndrome.
Drugs, Chinese Herbal ; administration & dosage ; adverse effects ; Female ; Hormone Replacement Therapy ; adverse effects ; methods ; Hormones ; administration & dosage ; adverse effects ; Humans ; Perimenopause ; drug effects ; physiology ; psychology

As the typical example of controlled release preparation, osmotic pump-controlled release preparation is a new technique of preparation characterized by zero order release kinetics. Osmotic pressure is the motivation for releasing drug. The release behavior of osmotically controlled release systems is independent of external pH and food, and the in vivo-in vitro correlation is good, so they have attracted wide attention at home and abroad. After years of development, with the constant innovation of the mechanism, the structure of the osmotic pump has been continuously improved, and many products have been marketed. In this article, the development history and the mechanism of osmotic pump-controlled release preparation are briefly reviewed. Based on solubility, osmotic pressure, the delivery orifice and the coating membrane, the critical factors affecting the release rate and the research progress on osmotic pump controled release preparation are mainly discussed.

Objective To study the prevalence of atopic dermatitis (AD) in China. Method School children aged 6～ 20 were surveyed with questionnaire in different areas in our country. Results This survey was carried out in 22 cities and rural areas, distributed in 11 provinces. There were 548 AD patients（ 347 males and 201 females） in a total population of 78 586. The total standardized prevalence (SP) was 0.69％ . The SPs of the males and the females were 0.84％ and 0.51％ , respectively, the difference being statistically significant(P

Objective To explore the diagnostic value of color Doppler ultrasonography and ultrasonography in the differential diagnosis of ectopic pregnancy.Methods 142 patients with ectopic pregnancy were given ultrasonic examination,to observe whether intrauterine gestational sac,carefully looking for recognition of ovarian masses and distinguish the relationship and structure,and were compared with pathologic diagnosis.Results Ultrasound could clearly display the uterus,ovary,failed to break the gestational sac and blood(block) mass image structure,with pathological diagnosis coincidence rate was 95.1％ (135/142),the misdiagnosis rate was 1.4％ (2/142),the missed diagnosis rate of 3.5％ (5/142).Conclusion Ultrasound was rapid,simple,noninvasive,high-accuracy,it was the preferred method for early diagnosis of the ectopic pregnancy.

Objective To investigate the value of preoperative total abdominal spiral CT scan in evaluating the staging of ovarian cancer.Methods Clinical data of 42 patients with ovarian cancer undergoing total abdominal spiral CT were collected.The CT images were retrospectively analyzed,and the CT staging and surgical pathologic staging were compared.Results Multi-slice spiral CT on ovarian cancer invasion and metastasis has high accuracy of diagnosis.The diagnostic accuracy of this group for direct tumor invasion,peritoneal metastasis,lymph node metastasis and ascites was 66％-100％.The correct preoperative staging were 34 cases:6 cases in stage I,6 cases in stage Ⅱ,17 cases in stage Ⅲ,5 cases in stage Ⅳ,and the staging accuracy of 80.9％.Conclusion Total abdominal multi-slice spiral CT examination is of great value in preoperative staging of ovarian cancer.

OBJECTIVE:To study the effects of carbamylated erythropoietin(CEPO)on cardiovascular microcirculation in rats with diabetes mellitus. METHODS:Rats were randomly divided into blank control group,model group,CEPO low-dose,medi-um-dose and high-dose groups(500,1 000,2 000 u/kg)with 12 in each group. The rats in the last 4 groups were reduced diabetes mellitus model. All rats were given relevant medicine intragastrically twice a week,coronary microcirculation endothelial cells were separated after consecutive 4 weeks. Enzyme-linked immunosorbent assay was conducted to detect levels of peripheral serum prosta-cyclin (PGI2),vasoconstrictor endothelin-1 (ET-1),angiotensin Ⅱ(AngⅡ) and von Willebrand factor (vWF) of rats in each group;in vitro CCK 8 test was used to detect endothelial cell activity(OD value);real-time quantitative polymerase chain reaction was adopted to detect proliferation-related genes(Ki67,p16),poptosis-related genes(Bad,Bax),and expressions of protein vas-cular endothelial growth factor(VEGF)and AngⅠ. RESULTS:Compared with blank control group,levels of PGI2,ET-1,AngⅡand vWF in serum in model group increased;OD value deceased;Ki67,p16,Bax and VEGF expression decreased;the difference was statistically significant (P<0.05). Compared with model group,levels of PGI2,ET-1,AngⅡ and vWF in serum in CEPO low-dose,medium-dose and high-dose groups increased;OD value increased;Ki67,p16 and VEGF expression increased;expres-sions of Bad and Bax decreased;the difference was statistically significant(P<0.05). The others had no significant difference(P>0.05). CONCLUSIONS:CEPO maybe improve the coronary microcirculation function by upregulating VEGF expression in coro-nary microcirculation endothelial cells and promoting endothelial cells’regeneration.

Liver metastasis is the advanced stage of gastric cancer,which is a leading cause of death.Radiofrequency ablation (RFA) is an alternative method of comprehensive treatment in patients with gastric cancer liver metastasis due to its advantages of safety,minimal invasion and repetition.The efficacy of RFA alone,the efficacy of the combined treatment of RFA with other therapies and prognostic factors of RFA in gastric cancer liver metastasis were reviewed in this article.