In recent several decades, studies have reported the representation of attention deficit/hyperactivity disorder(ADHD) symptoms could co-morbid in children with autism spectrum disorders(ASD).Compared with the ASD-only group, children with both ADHD and ASD often have a more obvious representation of autism symptom as well as more impaired cognitive functions which could deeply impact on their daily life.There is a brief review of observation and executive functions in ASD children co-morbid ADHD-symptoms.

Objective To observe the efficacy and safety of Compound Kaliziran Tincture combined with 0.1%Mometasone Furoate Cream in the treatment of vitiligo. Methods A total of 120 patients of vitiligo were randomly recruited into a control group (54 cases) and a treatment group (66 cases). The treatment group was treated with compound kaliziran tincture combined with 0.1% mometasone furoate cream for external use, while the control group was treated with topical 0.1% mometasone furoate cream. Both groups received the treatment for one course of three months. Efficacy was assessed at the end of the course. Results The total effective rate was 60.94% and 32.69% in the treatment group and the control group respectively, the difference showing statistical significance (χ2=7.86, P＜0.05) . Conclusion It is safe and effective for compound kaliziran tincture combined with 0.1% mometasone furoate in the treatment of vitiligo with few side effects. The combined therapy is better than single using 0.1% mometasone furoate cream.

OBJECTIVEA fluorescence probe marked with a specific angle protein antibody by using quantum dots QDs605-CK (AE1/AE3) was utilized to detect metastasis and micrometastasis rates of early submandibular lymph node metastatic carcinoma in a nude mouse model. The method was compared with traditional immunohistochemistry (IHC) staining and hematine-eosin (HE) staining to explore a new method for early diagnosis and treatment of tongue squamous cell carcinoma.

METHODSHuman tongue Tca8113 cells were cultured and inoculated in 18 nude mice tongue body tissues (except the midline) to establish submandibular lymph node metastasis in tumor-bearing nude mice models. The nude mice were sacrificed, and the mandibular lymph node was dissected after injecting tumor cells for six weeks. One lymph node was divided into two parts: one was used to create a serial section embedded by paraffin then detected in HE staining and IHC staining; the other was immediately frozen in liquid nitrogen and detected using the fluorescence probe marked with a specific angle protein antibody by using quantum dots. Lymph node metastasis and micrometastases rates were calculated.

RESULTSThe rates of metastasis in the submandibular lymph node via quantum dot immunofluorescence staining, IHC staining, and HE staining showed positive values of 66.7%, 61.1%, and 27.8%, respectively. The micrometastases rates were 38.9% and 33.3% via quantum dot immunofluorescence staining and IHC staining, respectively. The positive rates of detecting lymph nodes metastasis with quantum dot labeled keratin CK (AEl/AE3) immunofluorescence and keratin CK (AE1/AE3) IHC staining were higher than that of conventional HE staining ('=6.379, P<0.05). The two methods showed no statistical difference (chi2 = 0.120, P > 0.05).

CONCLUSIONQuantum dots fluorescent probe marked with the angle protein antibody CK (AE1/ AE3) can precisely locate the submandibular lymph node metastasis tumor cell of the nude mice tongue squamous cell carcinoma, and the emitted red fluorescence showed strong specificity, high resolution, and a clear background. The method could be utilized to detect submandibular lymph node metastasis and micrometastasis of tongue squamous cell carcinoma in nude mice.

Animals ; Fluorescence ; Humans ; Immunohistochemistry ; Lymph Nodes ; Lymphatic Metastasis ; Mice ; Mice, Nude ; Neck ; Neoplasm Micrometastasis ; Quantum Dots ; Tongue ; Tongue Neoplasms

High quality of fertility and pregancy is a specific presentation of family planning in this new historic environment. Our country adopted two-child policy from November, 2013. This symbolized an adjustive stage of reproduction policy in 21st century. It is a major adjustment in the development of national population. As a contry of tremendous population, it is very important to have a high- quality fertility and pregancy for the future of the whole nation, which would improve population quality and restrict development of population. The morbidity of infertility has increased significantly, which brings a huge crisis for national population. Under the guidance of high-quality fertility and pregancy in Chinese medicine theory, improving fertile women's ability of high-quality fertility and pregancy, and follow-up studying is of vital importance for evaluating the treatment of abortion prevention by traditional Chinese medicine and human health of high-quality fertility and pregancy.
Adult ; Blood Circulation ; drug effects ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Follow-Up Studies ; Humans ; Infertility, Female ; drug therapy ; physiopathology ; Kidney ; drug effects ; physiopathology ; Medicine, Chinese Traditional ; Pregnancy ; Pregnancy Outcome ; Reproduction

Embryonic diapauses mean that early embryos stop developing for some reasons in early pregnant stage. The embryo has dead in uterine cavity, but has not yet discharged. The early clinical manifestation in the areas of traditional Chinese medicine (TCM) can be classified as "pregnant vaginal bleeding", "fetal irritability" and other diseases. Embryonic diapause is a common and difficult gynecologic clinical disease. The prevalence rate which is increasing has become a major reproductive health problem. So the prevention research of embryonic diapauses is very significant. In this paper, through the induction and the summary of Chinese and Western medicine dynamic researches and control methods of embryonic diapauses, detailing a list of pathogenesis and treatment progress in embryonic diapauses. Besides, it can lay the foundation for further study and reducing embryonic diapauses incidence, which can promote reproductive health development.
Fetal Growth Retardation ; etiology ; metabolism ; prevention & control ; psychology ; Humans ; Medicine ; methods ; Medicine, Chinese Traditional ; methods ; Western World

With rapid social development rhythm, the incidence of gynecological diseases gradually rise. Traditional Chinese medicine has made irreplaceable position in the treatment of gynecological disease. Due to the characteristics of gynecological diseases, the syndrome differentiation and treatment has unique characteristics. In this paper, according to menstrual disease, leukorrheal diseases, pregnancy diseases, puerperal diseases and miscellaneous diseases in order, combining documents discussion and old doctors of traditional Chinese medicine treatment of gynecological disease experiences, illustrate the key points of drug selection in the treatment process. We can get a revelation that appropriate choice of tradition Chinese medicine is an indispensable part for healing effects. Through the analysis of characteristics of drugs, we can understand the feature of each period in disease of department of gynecology, increase the ability of usinig traditional Chinese medicine and improve the level of clinical treatment.
Female ; Genital Diseases, Female ; drug therapy ; Humans ; Leukorrhea ; drug therapy ; Medicine, Chinese Traditional ; methods ; Menstruation Disturbances ; drug therapy ; Practice Patterns, Physicians' ; Pregnancy ; Pregnancy Complications ; drug therapy ; Puerperal Disorders ; drug therapy ; Treatment Outcome

Spinal giant cell tumor of bone (GCTB) is a kind of primary benign bone tumors in the spine. It is rich in blood supply,aggressive,and easily recurring and lung metastasizing. So the benign GCTBs of the spine remains a challenge to treat.This article reviews the therapeutic methods in spinal GCTBs,including surgery,radiation therapy,arterial embolization. The treatment for the tumor with lung metastasis is also covered in this review. It is established that En bloc resection with wide margins is the most effective method to spinal GCTBs. To eliminate the residual tumor cells,adjuvant radiation should be done when complete resection is not available. Arterial embolization can be used to treat the huge sacral GCTBs.For those with lung metatasis,they can be controlled by lobectomy and /or chemotherapy.

Objective:To observe the effect of ischemic preconditioning(IP)on hepatocellular apoptosis caused by ischemia-reperfus ion(IR)injury and expression of apoptosis regulatory genes(Survivin,HIF-1?)protein,to explore the protective mechanisms of IP on IR injury in rat liver.Methods:Ninty SD rats were randomly divided into sham operation(SO)group,ischemia-reperfusion(IR)group,ischemic preconditioning(IP)group.In SO group,the hepatoduodenal ligament of rat was only pulled and separated,and then closed the abdomen;IR group subjected to 30 minutes of ischemia;IP group was achieved by ischemia for 5 minutes,followed by reperfusion for 5 minutes before continuous to ischemia for 30 minutes.Ten rats of each group were killed after reperfusion for 2,6,12,24 hours respectively,then liver tissues were taken out.The rats in SO group were killed after operation for 2 hours.To detect the Apotosis index(A)Iand Survivin,HIF-1? protein levels.Results:AI of hepotocytes significantly increased in IR group and IP group than that in SO group(P

Objective To investigate the changes of blood cell distribution width and D-dimer in patients with chronic obstructive pulmonary disease.Methods 60 cases with chronic obstructive pulmonary disease were selected and according to the course of disease were divided into two groups.30 healthy people were selected to be the control group.MCV, RDW and D-dimer were detected and compared.ResuIts Compared with the control group, MCV and RDW of acute phase group and remission stage group are higher(P<0.05), compared with the remission stage group, MCV and RDW of acute phase group were higher(P<0.05), and RDW and MCV in the acute stage group were positively correlated with the remission stage group (r=0.717, 0.902, P<0.05).Compared with the control group, D-dimer of acute phase group and remission stage group were higher(P<0.05), compared with the remission stage group, D-dimer of acute phase group were higher(P<0.05), and D-dimer in the acute stage group were positively correlated with the remission stage group (r=0.727, P<0.05).ConcIusion The distribution of blood cell distribution width and D-dimer levels in patients with chronic obstructive pulmonary disease in acute stage and remission stage group were increased, and the increasing of patients with chronic obstructive pulmonary disease in the acute stage is more obvious.