Objective To investigate the influence of insulin pump on type 2 diabetes mellitus.Methods 51 patients were randomized into two groups: 31 cases controlled with insulin pump,20 treated with oral antidiabetic drugs.Serum level of C-peptide concentration was observed.Results There was a markedly increase in C-peptide level in both insulin treating group(P<0.001) and oral drug group(P<0.01).Half an year later,the insulin group was improved in β-cell function better than oral drug group.Conclusions Several days controlling of severe hyperglycemia with insulin pump could not eliminate the β-cell inhibition of glucose toxicity.Newly diagnosed severe type 2 diabetes(FPG≥14 mmol/L) could be treated with insulin for several months.

With the higher and higher application level of medical information technology, the construction of digital hospital has been a trend in the field of medical information. Based on the opinions of domestic and foreign experts, this paper introduces the definition of digital hospital and analyzes different application levels in digital hospital. The key technology is discussed in detail.

Objective To observe whether the high-flow nasal cannulae (HFNC) can reduce the rate of re intubation after extubation in patients with tracheal intubation in the intensive care unit (ICU). Methods 134 patients with mechanical ventilation in ICU were divided into 2 groups according to the order of ICU. The control group and the observation group were divided into 67 groups. Patients in control group were used routine oxygen inhalation (nasal duct and mask) after weaning, while the observation group was HFNC. All the other patients with the same treatment and care. The rate of re intubation was compared between the 2 groups. Results In the observation group, the rate of reintubation was 4.48%(3/67) of all. The control group was 14.92%(10/67), two groups of patients with reintubation rate difference was statistically significant (χ2= 4.17, P < 0.05). Conclusions HFNC can decrease the rate of re intubation after extubation in patients with tracheal intubation.

Bilateral ablation of the cerebral parietal cortex in adult rats was performed. After appropriate days, the tissue surrounding the wound was removed and the brain wound tissue extract (EWTE) was prepared. Newborn rat cerebral cortical neurons were used as a culture model to test the neuronotrophic factors (NTFs) and neuritepromoting factors (NPFs) in EWTE. In order to investigate the origin of above mentioned factors whether related to the macrophages which appeared in the brain wound region at early stage, we designed to culture macrophages and collected the macrophage conditioned medium (M?CM) to measure their NTF and NPF activities for cultured cerebral cortical neurons. On the other hand, we also observed the effect of EWTE and M?CM on PC 12 (phehrmytema) cells and further studied the action of NPFs. Cur experimental results show that EWTE and M?CM contained NTFs and NPFs for cultured cerebral cortical neurons. These factors appeared in EWTE at 4 days post-lesion, with maximal level of their activities reached between 5 and 6 days post-lesion and there was another peak of NPF activity at 9 days post-lesion, until 13 days post-lesion also detected their activities. The NTF activity in M?CM was lower than that in BWTE, in contrast, the NPF activity in M?CM was higher than that in BWTE. There was NPF activity to PC 12 cells in BWTE and M?CM. According to the experimental assays, we suppose that the neurotrophic factors in BWTE mainly come from the macrophages which appear in the lesion site at early stage of injured brain, subsequently, it may relate to the astrocytes. The components of these factors may be complexity and multiplicity that remain to be solved.

ObjectiveTo study the expression of C3d in bullous pemphigoid lesions and its clinical significance.MethodsThe immunohistochemical SP method was used to detect the expression of C3d,IgG and IgA in tissue specimens from the lesions of 25 patients with bullous pemphigoid,10 patients with epidermolysis bullosa and normal skin of 10 human controls.The expression rates of these proteins were compared.Results The expression rates of C3d,IgG and IgA were 96％,72.0％ and 0 respectively in bullous pemphigoid tissue.Significant differences were found in the expression rates between C3d and IgG (x2 =4.17,P ＜ 0.05),as well as between C3d and IgA(x2 =22.04,P ＜ 0.01 ),in bullous pemphigoid tissue.No expression of C3d,IgG or IgA was observed in epidermolysis bullosa lesions or the control skin.ConslusionThe detection of C3d with immunohistochemistry in paraffin-embedded tissue sections may facilitate the diagnosis of bullous pemphigoid.

Objective To investigate the influence of insulin pump on type 2 diabetes mellitus.Methods 51 patients were randomized into two groups: 31 cases controlled with insulin pump,20 treated with oral antidiabetic drugs.Serum level of C-peptide concentration was observed.Results There was a markedly increase in C-peptide level in both insulin treating group(P

Spinal giant cell tumor of bone (GCTB) is a kind of primary benign bone tumors in the spine. It is rich in blood supply,aggressive,and easily recurring and lung metastasizing. So the benign GCTBs of the spine remains a challenge to treat.This article reviews the therapeutic methods in spinal GCTBs,including surgery,radiation therapy,arterial embolization. The treatment for the tumor with lung metastasis is also covered in this review. It is established that En bloc resection with wide margins is the most effective method to spinal GCTBs. To eliminate the residual tumor cells,adjuvant radiation should be done when complete resection is not available. Arterial embolization can be used to treat the huge sacral GCTBs.For those with lung metatasis,they can be controlled by lobectomy and /or chemotherapy.

Hydronephrosis is one of the most common urological diseases in children.Most of hydronephrosis caused by ureteropelvic junction obstruction.Whether these children need operations were being argued.The current tendency is when the renal function become worse,operation is suggested needed,in order to save the renal function.So the methods how to evaluate the renal function are especially important,this article related to the current research and review.

Objective To evaluate the clinical applicational value of color doppler flow image(CDFI)to perforation of ventricular septum resulting from myocardial infarct.Methods Before 7 cases confirmed perforation of ventricular septum though DSA,were examined by CDFI.The two results were compared to study the difference of bothes.Results All patients' results though CDFI were as the same as those though DSA,and accuracy rating was 100%.Conclusion CDFI may be applicated to early diagnose perforation of ventricular septum.

Objective:To explore the essence of Radix Morindae Officinalis in strengthening bones through observing the effect of medicated serum of Radix Morindae Officinalis on cultured osteoblast in vitro. Methods:The medicated serum of Radix Morindae Officinalis was added to the osteoblasts which were separated from the cranium of 24-hours newborn SD rat,in order to determining the effect of TGF-?1 and the proliferation and secreting of alkaline phosphatase and osteocalcin of the osteoblasts. Results:The proliferation of the osteoblasts were signifi cantly stimulated by the alcohol and the n-butanol extract from the Radix Morindae Officinalis; and the n-butanol extract from the Radix Morindae Officinalis could promote differentiating OB excreting the ALP and OC;in addition,the ability of the osteoblasts expressing TGF-?1 was promoted by the n-butanol extract from the Radix Morindae Officinalis. Conclusion:The n-butanol extract from the Radix Morindae Officinalis can promote the ability of the osteoblast in expressing TGF-?1 mRNA and excreting the ALP,and further promote the growth of bone.