Objective To observe whether the high-flow nasal cannulae (HFNC) can reduce the rate of re intubation after extubation in patients with tracheal intubation in the intensive care unit (ICU). Methods 134 patients with mechanical ventilation in ICU were divided into 2 groups according to the order of ICU. The control group and the observation group were divided into 67 groups. Patients in control group were used routine oxygen inhalation (nasal duct and mask) after weaning, while the observation group was HFNC. All the other patients with the same treatment and care. The rate of re intubation was compared between the 2 groups. Results In the observation group, the rate of reintubation was 4.48%(3/67) of all. The control group was 14.92%(10/67), two groups of patients with reintubation rate difference was statistically significant (χ2= 4.17, P < 0.05). Conclusions HFNC can decrease the rate of re intubation after extubation in patients with tracheal intubation.

Spinal giant cell tumor of bone (GCTB) is a kind of primary benign bone tumors in the spine. It is rich in blood supply,aggressive,and easily recurring and lung metastasizing. So the benign GCTBs of the spine remains a challenge to treat.This article reviews the therapeutic methods in spinal GCTBs,including surgery,radiation therapy,arterial embolization. The treatment for the tumor with lung metastasis is also covered in this review. It is established that En bloc resection with wide margins is the most effective method to spinal GCTBs. To eliminate the residual tumor cells,adjuvant radiation should be done when complete resection is not available. Arterial embolization can be used to treat the huge sacral GCTBs.For those with lung metatasis,they can be controlled by lobectomy and /or chemotherapy.

With the higher and higher application level of medical information technology, the construction of digital hospital has been a trend in the field of medical information. Based on the opinions of domestic and foreign experts, this paper introduces the definition of digital hospital and analyzes different application levels in digital hospital. The key technology is discussed in detail.

Bilateral ablation of the cerebral parietal cortex in adult rats was performed. After appropriate days, the tissue surrounding the wound was removed and the brain wound tissue extract (EWTE) was prepared. Newborn rat cerebral cortical neurons were used as a culture model to test the neuronotrophic factors (NTFs) and neuritepromoting factors (NPFs) in EWTE. In order to investigate the origin of above mentioned factors whether related to the macrophages which appeared in the brain wound region at early stage, we designed to culture macrophages and collected the macrophage conditioned medium (M?CM) to measure their NTF and NPF activities for cultured cerebral cortical neurons. On the other hand, we also observed the effect of EWTE and M?CM on PC 12 (phehrmytema) cells and further studied the action of NPFs. Cur experimental results show that EWTE and M?CM contained NTFs and NPFs for cultured cerebral cortical neurons. These factors appeared in EWTE at 4 days post-lesion, with maximal level of their activities reached between 5 and 6 days post-lesion and there was another peak of NPF activity at 9 days post-lesion, until 13 days post-lesion also detected their activities. The NTF activity in M?CM was lower than that in BWTE, in contrast, the NPF activity in M?CM was higher than that in BWTE. There was NPF activity to PC 12 cells in BWTE and M?CM. According to the experimental assays, we suppose that the neurotrophic factors in BWTE mainly come from the macrophages which appear in the lesion site at early stage of injured brain, subsequently, it may relate to the astrocytes. The components of these factors may be complexity and multiplicity that remain to be solved.

Objective To investigate the influence of insulin pump on type 2 diabetes mellitus.Methods 51 patients were randomized into two groups: 31 cases controlled with insulin pump,20 treated with oral antidiabetic drugs.Serum level of C-peptide concentration was observed.Results There was a markedly increase in C-peptide level in both insulin treating group(P<0.001) and oral drug group(P<0.01).Half an year later,the insulin group was improved in β-cell function better than oral drug group.Conclusions Several days controlling of severe hyperglycemia with insulin pump could not eliminate the β-cell inhibition of glucose toxicity.Newly diagnosed severe type 2 diabetes(FPG≥14 mmol/L) could be treated with insulin for several months.

ObjectiveTo study the expression of C3d in bullous pemphigoid lesions and its clinical significance.MethodsThe immunohistochemical SP method was used to detect the expression of C3d,IgG and IgA in tissue specimens from the lesions of 25 patients with bullous pemphigoid,10 patients with epidermolysis bullosa and normal skin of 10 human controls.The expression rates of these proteins were compared.Results The expression rates of C3d,IgG and IgA were 96％,72.0％ and 0 respectively in bullous pemphigoid tissue.Significant differences were found in the expression rates between C3d and IgG (x2 =4.17,P ＜ 0.05),as well as between C3d and IgA(x2 =22.04,P ＜ 0.01 ),in bullous pemphigoid tissue.No expression of C3d,IgG or IgA was observed in epidermolysis bullosa lesions or the control skin.ConslusionThe detection of C3d with immunohistochemistry in paraffin-embedded tissue sections may facilitate the diagnosis of bullous pemphigoid.

Objective To investigate the influence of insulin pump on type 2 diabetes mellitus.Methods 51 patients were randomized into two groups: 31 cases controlled with insulin pump,20 treated with oral antidiabetic drugs.Serum level of C-peptide concentration was observed.Results There was a markedly increase in C-peptide level in both insulin treating group(P

Hydronephrosis is one of the most common urological diseases in children.Most of hydronephrosis caused by ureteropelvic junction obstruction.Whether these children need operations were being argued.The current tendency is when the renal function become worse,operation is suggested needed,in order to save the renal function.So the methods how to evaluate the renal function are especially important,this article related to the current research and review.

Objective To test the reliability and validity of the Chinese Version of the Depressive Cognition Scale (DCS) among the older people.Methods The sample consisted of 570 old people,collected by a demographic questionnaire,the Chinese version of DCS,and the Center for Epidemiological Studies Depression Scale (CES-D),then all the data was analyzed by SPSS 21.0.Results The item-to-total correlation coefficients of DCS ranged from 0.65 to 0.84 (P＜0.01),and the average coefficient was 0.77.The content validity index(CVI) was 0.88.The result of exploratory factor analysis (EFA) was that one factor explained 59.72％ of the total variances,and the concurrent validity between DCS and CES-D was positive related (r=0.24-0.82,P＜0.01).Regarding CES-D as the gold standard,the sensitivity was 84.7％ and the specificity was 90.7％.The inter-item correlation coefficients of DCS ranged from 0.40 to 0.73 (P＜0.01);the Cronbach α was 0.82,and the retest reliability (intra-class correlation coefficient,ICC) was 0.92 (95％CI=0.86-0.95,P＜0.01).Conclusion DCS is proved to be a reliable and valid instrument,and it can be used to assess the depressive cognition and screen the early depressive symptoms of Chinese old adults.

Objective To test the reliability and validity of the Chinese version of the sense of coherence (SOC) scale (13-items) among the older people.Methods A random sample of 1 032 old adults was selected from community in Jinzhou,Shenyang,Dalian of Liaoning.A demographic questionnaire,the SOC-13 scale,the WHO-5 and the Center for Epidemiological Studies Depression Scale (CES-D) were used to collect the data.All the data was analyzed by SPSS 21.0 and AMOS17.0.Results The item-total correlation coefficients of SOC-13 ranged from 0.625 to 0.760 (P＜ 0.01).The result of exploratory factor analysis (EFA) was that three factors explained 74.745％ of the total variances,and the CFA confirmed the hypothesized three-factor model.SOC scale had an ideal criterion(x2/df =2.908,CFI =0.975,GFI =0.949,NFI =0.963,IFI=0.975,RMSEA=0.061).Criterion related validity test showed that the total score of SOC-13 was negatively correlated with CES-D(r=-0.55,P＜0.01),and positively correlated with WHO-5 (r=0.73,P＜ 0.01).SOC-1 3 had a Cronbach's α of 0.916,the Guttman split-half coefficient was 0.828,and the retest reliability (intra-class correlation coefficient,ICC) was 0.872 (P＜0.01).Conclusion SOC-13 is a reliable and valid instrument,which can be used to measure the lever of sense of coherence among Chinese old adults.