3.Effectiveness and Safety of Biolimus A9™-Eluting stEnt in Patients with AcUTe Coronary sYndrome; A Multicenter, Observational Study (BEAUTY Study)
Keun Ho PARK ; Myung Ho JEONG ; Young Joon HONG ; Youngkeun AHN ; Hyun Kuk KIM ; Young Yub KOH ; Doo Il KIM ; Sang Wook KIM ; Weon KIM ; Seung Woon RHA ; Jay Young RHEW ; Jong Seon PARK ; Hun Sik PARK ; Jang Ho BAE ; Jang Whan BAE ; Seok Kyu OH ; Sung Yun LEE ; Seung Wook LEE ; Jae Hwan LEE ; Sang Yeob LIM ; Jang Hyun CHO ; Kwang Soo CHA ; Jai Keon CHAE ; Seung Ho HUR ; Sun Ho HWANG ; Jin Yong HWANG
Yonsei Medical Journal 2018;59(1):72-79
PURPOSE: This study sought to determine the 1-year clinical effectiveness and safety of a biodegradable, polymer-containing Biolimus A9™-eluting stent (BES) in Korean patients with acute coronary syndrome (ACS). MATERIALS AND METHODS: A total of 1000 ACS patients with 1251 lesions who underwent implantation of BESs at 22 centers in Korea were enrolled between May 2011 and July 2013. We assessed major adverse cardiac events (MACE) defined as the composite of cardiac death, non-fatal myocardial infarction (MI), and clinical-driven target vessel revascularization at 12 months. RESULTS: Patient mean age was 62.6±11.4 years. 72.8% of the patients were male, 28.5% had diabetes, 32.8% had multi-vessel disease (MVD), and 47.9% presented with acute MI (AMI). The mean global registry of acute coronary events risk score of all patients was 103.0±27.6. The number of stents per patient was 1.3±0.6. The incidences of MACE and definite stent thrombosis at 12 months were 3.9% and 0.2%, respectively. On multivariate Cox-regression analysis, age ≥65 years was identified as an independent predictors of 1-year MACE (hazard ratio=2.474; 95% confidence interval=1.202−5.091). Subgroup analyses revealed no significant differences in the incidence of MACE between patients with and without diabetes (4.3% vs. 3.7%, p=0.667), between those who presented with and without AMI (4.4% vs. 3.4%, p=0.403), and between those with and without MVD (4.6% vs. 3.5%, p=0.387). CONCLUSION: Our study demonstrated excellent 1-year clinical outcomes of BES implantation in patients at low-risk for ACS.
Acute Coronary Syndrome/drug therapy
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Aged
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Drug-Eluting Stents/adverse effects
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Female
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Humans
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Incidence
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Kaplan-Meier Estimate
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Male
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Middle Aged
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Multivariate Analysis
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Proportional Hazards Models
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Republic of Korea
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Sirolimus/adverse effects
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Sirolimus/analogs & derivatives
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Sirolimus/therapeutic use
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Time Factors
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Treatment Outcome
4.Clinical features and outcomes of gastric variceal bleeding: retrospective Korean multicenter data.
Moon Young KIM ; Soon Ho UM ; Soon Koo BAIK ; Yeon Seok SEO ; Soo Young PARK ; Jung Il LEE ; Jin Woo LEE ; Gab Jin CHEON ; Joo Hyun SOHN ; Tae Yeob KIM ; Young Suk LIM ; Tae Hyo KIM ; Tae Hee LEE ; Sung Jae PARK ; Seung Ha PARK ; Jin Dong KIM ; Sang Young HAN ; Chang Soo CHOI ; Eun Young CHO ; Dong Joon KIM ; Jae Seok HWANG ; Byoung Kuk JANG ; June Sung LEE ; Sang Gyune KIM ; Young Seok KIM ; So Young KWON ; Won Hyeok CHOE ; Chang Hyeong LEE ; Byung Seok KIM ; Jae Young JANG ; Soung Won JEONG ; Byung Ho KIM ; Jae Jun SHIM ; Yong Kyun CHO ; Moon Soo KOH ; Hyun Woong LEE
Clinical and Molecular Hepatology 2013;19(1):36-44
BACKGROUND/AIMS: While gastric variceal bleeding (GVB) is not as prevalent as esophageal variceal bleeding, it is reportedly more serious, with high failure rates of the initial hemostasis (>30%), and has a worse prognosis than esophageal variceal bleeding. However, there is limited information regarding hemostasis and the prognosis for GVB. The aim of this study was to determine retrospectively the clinical outcomes of GVB in a multicenter study in Korea. METHODS: The data of 1,308 episodes of GVB (males:females=1062:246, age=55.0+/-11.0 years, mean+/-SD) were collected from 24 referral hospital centers in South Korea between March 2003 and December 2008. The rates of initial hemostasis failure, rebleeding, and mortality within 5 days and 6 weeks of the index bleed were evaluated. RESULTS: The initial hemostasis failed in 6.1% of the patients, and this was associated with the Child-Pugh score [odds ratio (OR)=1.619; P<0.001] and the treatment modality: endoscopic variceal ligation, endoscopic variceal obturation, and balloon-occluded retrograde transvenous obliteration vs. endoscopic sclerotherapy, transjugular intrahepatic portosystemic shunt, and balloon tamponade (OR=0.221, P<0.001). Rebleeding developed in 11.5% of the patients, and was significantly associated with Child-Pugh score (OR=1.159, P<0.001) and treatment modality (OR=0.619, P=0.026). The GVB-associated mortality was 10.3%; mortality in these cases was associated with Child-Pugh score (OR=1.795, P<0.001) and the treatment modality for the initial hemostasis (OR=0.467, P=0.001). CONCLUSIONS: The clinical outcome for GVB was better for the present cohort than in previous reports. Initial hemostasis failure, rebleeding, and mortality due to GVB were universally associated with the severity of liver cirrhosis.
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Asian Continental Ancestry Group
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Endoscopy
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Esophageal and Gastric Varices/*diagnosis/mortality/therapy
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Female
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*Gastrointestinal Hemorrhage
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Humans
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Male
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Middle Aged
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Multivariate Analysis
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Odds Ratio
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Prognosis
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Republic of Korea
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Retrospective Studies
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Sclerotherapy
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Severity of Illness Index
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Treatment Outcome
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Young Adult
5.Guideline for the Surgical Management of Locally Invasive Differentiated Thyroid Cancer From the Korean Society of Head and Neck Surgery
Jun-Ook PARK ; Joo Hyun KIM ; Young Hoon JOO ; Sang-Yeon KIM ; Geun-Jeon KIM ; Hyun Bum KIM ; Dong-Hyun LEE ; Hyun Jun HONG ; Young Min PARK ; Eun-Jae CHUNG ; Yong Bae JI ; Kyoung Ho OH ; Hyoung Shin LEE ; Dong Kun LEE ; Ki Nam PARK ; Myung Jin BAN ; Bo Hae KIM ; Do Hun KIM ; Jae-Keun CHO ; Dong Bin AHN ; Min-Su KIM ; Jun Girl SEOK ; Jeon Yeob JANG ; Hyo Geun CHOI ; Hee Jin KIM ; Sung Joon PARK ; Eun Kyung JUNG ; Yeon Soo KIM ; Yong Tae HONG ; Young Chan LEE ; Ho-Ryun WON ; Sung-Chan SHIN ; Seung-Kuk BAEK ; Soon Young KWON
Clinical and Experimental Otorhinolaryngology 2023;16(1):1-19
The aim of this study was to develop evidence-based recommendations for determining the surgical extent in patients with locally invasive differentiated thyroid cancer (DTC). Locally invasive DTC with gross extrathyroidal extension invading surrounding anatomical structures may lead to several functional deficits and poor oncological outcomes. At present, the optimal extent of surgery in locally invasive DTC remains a matter of debate, and there are no adequate guidelines. On October 8, 2021, four experts searched the PubMed, Embase, and Cochrane Library databases; the identified papers were reviewed by 39 experts in thyroid and head and neck surgery. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the quality of evidence, and to develop and report recommendations. The strength of a recommendation reflects the confidence of a guideline panel that the desirable effects of an intervention outweigh any undesirable effects, across all patients for whom the recommendation is applicable. After completing the draft guidelines, Delphi questionnaires were completed by members of the Korean Society of Head and Neck Surgery. Twenty-seven evidence-based recommendations were made for several factors, including the preoperative workup; surgical extent of thyroidectomy; surgery for cancer invading the strap muscles, recurrent laryngeal nerve, laryngeal framework, trachea, or esophagus; and surgery for patients with central and lateral cervical lymph node involvement. Evidence-based guidelines were devised to help clinicians make safer and more efficient clinical decisions for the optimal surgical treatment of patients with locally invasive DTC.