No abstract available.
Cardiomyoplasty*

A clinical observation was made on 97 cases of hydronephrosis who were admitted to the Urologic Department of the Maryknoll Hospital during the period from July 1, 1976 to December 31, 1981 (5 and 1/2 years). The results are as follows: 1. The rate of hydronephrosis accounted for 8.7% of the total patients (1,109 patients) admitted to the Urologic Department and 20.6% of the patients with urinary tract obstruction (471 patients). 2. The patients in this series were distributed over all ages, from a 12-month-old baby up to a 76-year-old patient. The most common age group Was the 5th decade (29.9%) and the male to female ratio was 1.5 to 1. 3. In underlying diseases, the most common cause of hydronephrosis was ureteral stone (40.2%), and 16.5%was idiopathic. 4. In lateralization of hydronephrosis, the left side was more affected than the right side by about 1.2 times and 19.6% was bilateral. In site and level of obstruction, upper tract was 76.3%, mid and lower tract was 7.2%, intraurinary tract lesion was 97.9% and extraurinary tract lesion was 2.1%. 5. The most commonly obstructed organ was the ureter (59.8%). 6. The most common symptom on admission was flank pain (46.8%). 7. In laboratory findings, increased B.U.N. and creatinine was 11.3%. Pyuria was 58.8% in urinalysis and the most common organism in urine culture was E. Coli (50.0%). 8. The most common complication of hydronephrosis was non-functioning kidney (42.2%). 9. In treatment, surgical treatment was 75.3% and conservative treatment, 24.7%. Of the surgical treatment, the most common operation was nephrectomy (30.9%), while the rate of conserving kidney was 69.1% and about 2.2 times higher than nephrectomy cases.
Aged ; Creatinine ; Female ; Flank Pain ; Humans ; Hydronephrosis* ; Infant ; Kidney ; Male ; Nephrectomy ; Pyuria ; Ureter ; Urinalysis ; Urinary Tract

BACKGROUND: Angiogenesis plays a critical role in human tumor growth and metastasis. Microvessel count, as a measure of tumor angiogenesis, has been significantly correlated with invasive and metastatic patterns in breast, prostate and cutaneous carcinomas. Materials and METHODS: Fifty patients with curatively resected non-small cell lung cancer were evaluated. Tumor tissues embedded in paraffin block were stained by anti CD 31 (PECAM, platelet endothelial cellular adhesion molecule) using immunohistochemical method to assess microvessel count. Microvessels were counted in the most active areas of neovascularization(microscopy, 200×). RESULTS: 1) Mean microvessel count was 47.1 ± 17.7(per 200×field) in total 50 cases. 2) Mean microvessel count of adenocarcinoma (54.4±19.9) was significantly higher than that of squamous cancer(43.9±16.2)(p<0.05), but there were no relationship between microvessel count and TNM stages. 3) Median survival time, 2-year and 5-year survival rates of the low microvascular group(microvessel count<45, 22cases) were 61 months, 80% and 40%, respectively, and those of the high microvascular group(microvessel count ≥ 45, 28 cases) were 46 months, 75% and 12%, respectively. As results, prognosis of low microvascular group is statistically significantly superior to that of the high microvascular group(p=0.0162, Kaplan-Meier, log-rank). CONCLUSION: Angiogenesis assessed by microvessel count can be used as one of the significant prognostic factors in non-small cell lung cancer.
Adenocarcinoma ; Blood Platelets ; Breast ; Carcinoma, Non-Small-Cell Lung* ; Humans ; Microvessels ; Neoplasm Metastasis ; Paraffin ; Prognosis ; Prostate ; Survival Rate

PURPOSE: To identify chronologic trends and characteristics, and to gain some insights into the future direction of the Korean Journal of Urology (KJU), all articles published in the KJU over the past 5 decades were analyzed. MATERIALS AND METHODS: The bibliometric data of the entire 6,730 articles published in the KJU were classified according to publication type (original articles, review articles, case reports), publication content (experimental articles, clinical articles), and 8 genitourinary fields: oncology, voiding dysfunction/female urology, endourology/urolithiasis, urinary tract infection (UTI), sexual dysfunction/infertility, pediatric urology, trauma, and medical/miscellaneous. The data were analyzed in the following chronological order: 1960s, 1970s, 1980s, 1990s, and 2000s. RESULTS: The number of articles published in the KJU has continuously increased annually. The proportion of original articles, which constituted 72.9% of articles overall, significantly increased in the 2000s (79.5%). Articles in the field of oncology constituted the largest proportion (37.6%) of total articles. The oncology and voiding dysfunction/female urology fields showed an increasing trend, but the UTI field showed a decreasing trend. The fields of sexual dysfunction/infertility and voiding dysfunction/female urology began to increase in the 1990s. The percentage of experimental articles, which was 8.4% in the 1970s, and 9.0% in the 1980s, increased to 20.4% in the 1990s. Recently, the KJU was registered in some international journal databases in recognition of its scientific excellence. CONCLUSIONS: These results make up an index reflecting academic and practicing performances in urology. We hope that the KJU will soon be recognized as one of the high-quality international peer-reviewed journals.
Bibliometrics ; Korea ; Publications ; Urinary Tract Infections ; Urology

No abstract available.
Angiotensin II* ; Angiotensins* ; Animals ; Endocrine System* ; Rats*

Leiomyoma is a benign tumor, which usually occur at the smooth muscle of the gastrointestinal tract and uterus but rarely occurs on the corpus cavernosum of the penis. We experienced a patient with leiomyomas on the bilateral corpus cavernosa of the penis accompanied with impotence in a 60-year-old man. The patient was treated with complete local excision and has remained well without recurrence for l year, So we report this case with review of literatures.
Erectile Dysfunction ; Gastrointestinal Tract ; Humans ; Leiomyoma* ; Male ; Middle Aged ; Muscle, Smooth ; Penis* ; Recurrence ; Uterus

Torsade de pointes (TdP) is a form of polymorphic ventricular tachycardia that is associated with prolongation of the QT interval. Although it occurs in many clinical settings, torsade de pointes is most commonly caused by drugs. The second generation antihistamines, including terfenadine and astemizole, have little sedation or other adverse effects on the CNS. They have been used widely to treat various allergic diseases, but it has been reported that overdoses or combinations with antifungal agents or macrolide antibiotics may lead to TdP. We report a case of TdP that occured during com-bination therapy of terfenadine and ketoconazole.
Anti-Bacterial Agents ; Antifungal Agents ; Astemizole ; Histamine H1 Antagonists, Non-Sedating ; Ketoconazole* ; Tachycardia, Ventricular ; Terfenadine* ; Torsades de Pointes*

BACKGROUND: The angiotensin converting enzyme(ACE) is a key component of the renin-angiotensin system thought to be important in the pathogenesis of hypertension and cadiovascular diseases. Deletion polymorphism in the ACE gene may be a risk factor for myocardial infarction. The insertion/deletion(I/D) polymorphism of the ACE detected by PCR analysis appears to be associated with hypertension in Koreans and its nucleotide was subcloned into T-vector and its nucleotide sequences were determined. We also examined an association between hypertension and genetic variance of ACE. METHODS AND RESULTS: We identified the angiotensin I-converting enzyme genotype in 127 hypertensive and 189 normotensive Korean subjects. The distribution of ACE genotype II, ID, DD were 39.2%, 40.2%, 20.6% respectively and the frequency for ACE alleles I and D were 0.593 and 0.407, respecively in all subjects. The frequency of D allele in Korean males is higher than that of Korean females(male; 0.438 : female; 0.267), and the frequency of I allele in Korean females is higher than that of Korean males(female; 0.733 : male; 0.562). Genotype distributions of angiotensin I-converting enzyme genes in Korean normal adult population were different from that of Caucasians(P<0.001). There were no significant differences in genotype frequency between the hypertensive control group(n=127) and the normotensive group(n=189). CONCLUSIONS: We observed significant differences of ACE genotype distribution between the male group and the female group in total(P=0.001) and in hypertensive Korean subjects(P=0.013).
Adult ; Alleles ; Angiotensins* ; Base Sequence ; Female ; Gene Frequency* ; Genotype* ; Humans ; Hypertension ; Male ; Myocardial Infarction ; Peptidyl-Dipeptidase A* ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Renin-Angiotensin System ; Risk Factors

Primary sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) of the thyroid gland is a very rare disease. We present the clinical and histopathologic findings of a 37-year-old woman recently diagnosed with SMECE of the thyroid gland. The patient, clinically euthyroid, who presented with a neck swelling since last 2 years along. Fine needle aspiration cytology suggested thyroid papillary carcinoma. Total thyroidectomy, central neck dissection and right selective neck dissection were performed. Although SMECE is considered to be a relatively slow growing and non-aggressive tumor, occasional metastasis does occur. We report an additional case of SMECE, with metastasis to regional lymph nodes. Physicians should be aware of extended operation, including total thyroidectomy and/or neck node dissection for metastatic lesion of the neck node. More standardized treatment is likely to evolve in the future.
Adult ; Biopsy, Fine-Needle ; Carcinoma, Mucoepidermoid* ; Carcinoma, Papillary ; Eosinophilia* ; Female ; Humans ; Lymph Nodes ; Neck ; Neck Dissection ; Neoplasm Metastasis ; Rare Diseases ; Thyroid Gland* ; Thyroidectomy

BACKGROUND: The nucleus tractus solitarius (NTS), the region of the brain stem in which primary baroreceptor afferents teminate, is critically important in the normal regulation of arterial pressure (AP). In the NTS, excitatory amino acids such as L-glutamate serve as the main neurotransmitter in the regulation of AP. However, the function of GABA in the NTS has not been established. To test the function of GABA, we applied GABAergic agents to the NTS. METHODS: The experiments were conducted on adult male Sprague-Dawley rats weighing 300-500g. A cannula (PE-50 tubing filled with heparinized saline) was inserted into the femoral artery for recording of AP and heart rate(HR). Another cannula was inserted into the femoral vein for administration of nitroprusside or phenylephrine. After rats were placed on a sterotaxic instrument, the dorsal surface of the medulla was exposed, and with the aid of a surgical microscope, the NTS was visualized. Drug injections were made into the NTS using single- or three-barreled grass micropipettes pulled to an outer diameter of 80-100(micro)m and connected to a 1(micro)l Hamilton syringe. RESULTS: The follwing results were obtained in this experiment. Injection into the NTS of 10 or 20 nmol nipecitic acid, a selective inhibitor of GABA untake, produced an increase in AP. The pressor responses evoked by two doses of nipecotic acid were not significantly different. Injection of GABA(A) agonist, musciml(5 pmol in 80 nl artificial CSF) and GABA(B) agonist, baclofen (20 pmol in 80 nl) into the NTS of urethane-anesthetized rats prodused an increase in AP of 16.6+/-1.3 and 27.6+/-1.5 mmHg, respectively. Thus the pressor response to GABA(B) agonist was greater than to GABA(A) agonist. On the other hand, microinjection of GABA(A) antagonist, bicuculline and GABA(B) antagonist, phaclofen into the NTS decreased AP by approximately 13.4+/-1.0 and 20.9+/- mmHg, respectively. Thus injection of nipecotic acid into the NTS was greater in control group compared with the muscimiol or baclofen groups. The AP changes caused by i.v. injection of nitroprusside or phenylephrine were smallest in control group and greatest in the baclofen group. When calculated as baroreflex sensitivity, the change was greatest in control group and smallest in the baclofen group. CONCLUSION: From these results it was concluded that GABA in the NTS plays an important role in the regulation of AP, especially through GABA(B) receptors, and have an inhibitory effect on baroreceptor reflex.
Adult ; Animals ; Arterial Pressure ; Baclofen ; Baroreflex ; Bicuculline ; Blood Pressure ; Brain Stem ; Catheters ; Excitatory Amino Acids ; Femoral Artery ; Femoral Vein ; GABA Agents ; gamma-Aminobutyric Acid* ; Glutamic Acid ; Hand ; Heart ; Heparin ; Humans ; Male ; Microinjections ; Neurotransmitter Agents ; Nitroprusside ; Phenylephrine ; Poaceae ; Pressoreceptors ; Rats ; Rats, Sprague-Dawley ; Solitary Nucleus* ; Syringes