1.A case of Ritter's disease.
Young Kui LEE ; Eun Mi KIM ; Dong Rak CHOI ; Hae Ran LEE ; Chong Young PARK
Journal of the Korean Pediatric Society 1992;35(6):840-844
No abstract available.
Staphylococcal Scalded Skin Syndrome*
2.An Adverse Effect Following Facial Hair Removal by Thread Shaving.
Sang Ju LEE ; Moo Yeol HYUN ; Kui Young PARK ; Seong Jun SEO
Korean Journal of Dermatology 2014;52(9):674-675
No abstract available.
Hair Removal*
3.An Adverse Effect Following Illegal Medical Procedure by Unlicensed Non-medical Personnel.
Sang Ju LEE ; In Kwon YEO ; Kui Young PARK ; Beom Joon KIM
Korean Journal of Dermatology 2014;52(3):205-206
No abstract available.
Nevus, Intradermal
4.Pharmacological treatment options for acne
Journal of the Korean Medical Association 2018;61(11):680-686
Acne vulgaris is a very common condition affecting up of about 80% to 90% of adolescents. The patients with acne have been shown to be adversely impacted by the effect of acne on their quality of life. Four factors are believed to play a key role in the development of acne lesions: excess sebum production, disturbed keratinization within the follicle, colonization of the pilosebaceous duct by Propionibacterium acnes, and the release of inflammatory mediators into the skin. Consequently, the target for acne therapy is these well-known pathogenic factors responsible for this disease state. Topical retinoids correct abnormal keratinization, but it should be applied cautiously because of irritation. Benzoyl peroxide is an effective bactericidal agent against P. acnes. Main topical antibiotics are erythromycin and clindamycin. Fixed combination topical products with retinoids, benzoyl peroxide and antibiotics have been introduced. Use of systemic antibiotics, including tetracyclines and macrolides rapidly improves inflammatory acne lesions. Oral isotretinoin is effective against all of the main pathogenic features of acne but is contraindicated in pregnant women and has been associated with cheilitis and dry skin. Hormonal therapy has been found to improve acne in some selective patients and should be considered for appropriate candidates. This review will present the general aspects of the pharmacological treatments for acne.
5.A Case of Bilateral Lower Leg Cellulitis Caused by Klebsiella pneumoniae.
Ga Ram AHN ; Hyun Jung KWON ; Kui Young PARK ; Seong Jun SEO
Korean Journal of Dermatology 2019;57(1):40-41
No abstract available.
Cellulitis*
;
Klebsiella pneumoniae*
;
Klebsiella*
;
Leg*
6.Pharmacological treatment options for acne
Journal of the Korean Medical Association 2018;61(11):680-686
Acne vulgaris is a very common condition affecting up of about 80% to 90% of adolescents. The patients with acne have been shown to be adversely impacted by the effect of acne on their quality of life. Four factors are believed to play a key role in the development of acne lesions: excess sebum production, disturbed keratinization within the follicle, colonization of the pilosebaceous duct by Propionibacterium acnes, and the release of inflammatory mediators into the skin. Consequently, the target for acne therapy is these well-known pathogenic factors responsible for this disease state. Topical retinoids correct abnormal keratinization, but it should be applied cautiously because of irritation. Benzoyl peroxide is an effective bactericidal agent against P. acnes. Main topical antibiotics are erythromycin and clindamycin. Fixed combination topical products with retinoids, benzoyl peroxide and antibiotics have been introduced. Use of systemic antibiotics, including tetracyclines and macrolides rapidly improves inflammatory acne lesions. Oral isotretinoin is effective against all of the main pathogenic features of acne but is contraindicated in pregnant women and has been associated with cheilitis and dry skin. Hormonal therapy has been found to improve acne in some selective patients and should be considered for appropriate candidates. This review will present the general aspects of the pharmacological treatments for acne.
Acne Vulgaris
;
Adolescent
;
Anti-Bacterial Agents
;
Benzoyl Peroxide
;
Cheilitis
;
Clindamycin
;
Colon
;
Drug Therapy
;
Erythromycin
;
Female
;
Humans
;
Isotretinoin
;
Macrolides
;
Pregnant Women
;
Propionibacterium acnes
;
Quality of Life
;
Retinoids
;
Sebum
;
Skin
;
Tetracyclines
7.Two Cases of Toenail Onychomycosis Treated by 1,064 nm Nd:YAG Laser.
Sang Ju LEE ; Young Koo KIM ; Sun Young CHOI ; Kui Young PARK
Korean Journal of Dermatology 2013;51(2):119-122
Onychomycosis is a relatively common fungal infection. Treatment modalities include oral and topical antifungals, surgical treatment or a combination of these therapies. But treatment failure is common and oral drugs may cause toxicity and potential drug interactions. Currently, there are few publications about the treatment of onychomycosis using photodynamic therapy or laser therapy. We report two cases of toenail onychomycosis treated by 1,064 nm Nd:YAG laser.
Drug Interactions
;
Laser Therapy
;
Nails
;
Onychomycosis
;
Photochemotherapy
;
Treatment Failure
8.Three Cases of Adverse Effects Following the Acupuncture in Oriental Medical Clinic.
Sang Ju LEE ; In Kwon YEO ; Kui Young PARK ; Young Koo KIM
Korean Journal of Dermatology 2013;51(3):189-191
Oriental medicine is a broad range of medical practices that are based on traditions. These traditions include various forms of herbal medicine, acupuncture, massage, exercise, and dietary therapy. The views of the body place little emphasis on anatomical structures, but are mainly concerned with the identification of functional entities. Recently, most oriental doctors have expanded their range of medical treatment into a variety of aspects, and have introduced treatment remedies that include unproved methods, especially into the field of dermatology. Herein, we present 3 cases of adverse effects following the acupuncture for congenital melanocytic nevus, syringoma, and acne scar in oriental medical clinic. With the increasing popularity of acupuncture, we need to understand the current status of dermatologic treatments conducted in oriental clinics.
Acne Vulgaris
;
Acupuncture
;
Cicatrix
;
Dermatology
;
Herbal Medicine
;
Hypogonadism
;
Massage
;
Medicine, East Asian Traditional
;
Mitochondrial Diseases
;
Nevus, Pigmented
;
Ophthalmoplegia
;
Syringoma
9.A Rapid Effect in Childhood Granulomatous Periorificial Dermatitis with Oral Metronidazole and Topical Tacrolimus.
Yeon A NO ; Moo Yeol HYUN ; In Young OH ; Kui Young PARK ; Kapsok LI ; Beomjoon KIM ; Seongjun SEO ; Myeungnam KIM ; Changkwun HONG
Korean Journal of Dermatology 2015;53(5):405-406
No abstract available.
Dermatitis*
;
Metronidazole*
;
Tacrolimus*
10.Adiponectin Upregulates Filaggrin Expression via SIRT1-Mediated Signaling in Human Normal Keratinocytes.
Taewon JIN ; Kui Young PARK ; Seong Jun SEO
Annals of Dermatology 2017;29(4):407-413
BACKGROUND: Filaggrin (FLG) is the major component of the epidermal granular layer and binds to and condenses the keratin cytoskeleton. FLG thus contributes to cell compaction and serves as a natural moisturizing factor by promoting unfolding and degradation into hygroscopic amino acids. Loss or downregulation of FLG has been shown to result in a weak stratum corneum, which causes water loss and increases the possibility of skin barrier-related seizure. Adiponectin (Acrp30) contributes to the functional recovery of somatic cells, including human normal epidermal keratinocytes (NHEKs). OBJECTIVE: To investigate the effect of Acrp30 in FLG expression and identifying its signal transduction mechanism. METHODS: Normal human keratinocytes were treated with Acrp30 and the levels of FLG were examined. Silent mating type information regulation 2 homolog (SIRT)-targeting siRNA and aryl hydrocarbon receptor nuclear translocator (ARNT)-targeting siRNA were used to identify the role of various signal transduction pathway components. RESULTS: Acrp30 upregulated SIRT1 and ARNT expression in NHEKs, resulting in increased FLG expression. Treatment with both SIRT1-targeting siRNA and ARNT-targeting siRNA blocked Acrp30 stimulation and silenced FLG expression. CONCLUSION: Adiponectin upregulates FLG expression through a SIRT1-mediated pathway. Our results suggest that Acrp30 is a promising agent for skin barrier permeability improvement.
Adiponectin*
;
Amino Acids
;
Aryl Hydrocarbon Receptor Nuclear Translocator
;
Cytoskeleton
;
Down-Regulation
;
Humans*
;
Keratinocytes*
;
Permeability
;
RNA, Small Interfering
;
Seizures
;
Signal Transduction
;
Skin
;
Water