No abstract available.
Staphylococcal Scalded Skin Syndrome*

No abstract available.
Nevus, Intradermal

No abstract available.
Hair Removal*

No abstract available.
Cellulitis* ; Klebsiella pneumoniae* ; Klebsiella* ; Leg*

Acne vulgaris is a very common condition affecting up of about 80% to 90% of adolescents. The patients with acne have been shown to be adversely impacted by the effect of acne on their quality of life. Four factors are believed to play a key role in the development of acne lesions: excess sebum production, disturbed keratinization within the follicle, colonization of the pilosebaceous duct by Propionibacterium acnes, and the release of inflammatory mediators into the skin. Consequently, the target for acne therapy is these well-known pathogenic factors responsible for this disease state. Topical retinoids correct abnormal keratinization, but it should be applied cautiously because of irritation. Benzoyl peroxide is an effective bactericidal agent against P. acnes. Main topical antibiotics are erythromycin and clindamycin. Fixed combination topical products with retinoids, benzoyl peroxide and antibiotics have been introduced. Use of systemic antibiotics, including tetracyclines and macrolides rapidly improves inflammatory acne lesions. Oral isotretinoin is effective against all of the main pathogenic features of acne but is contraindicated in pregnant women and has been associated with cheilitis and dry skin. Hormonal therapy has been found to improve acne in some selective patients and should be considered for appropriate candidates. This review will present the general aspects of the pharmacological treatments for acne.
Acne Vulgaris ; Adolescent ; Anti-Bacterial Agents ; Benzoyl Peroxide ; Cheilitis ; Clindamycin ; Colon ; Drug Therapy ; Erythromycin ; Female ; Humans ; Isotretinoin ; Macrolides ; Pregnant Women ; Propionibacterium acnes ; Quality of Life ; Retinoids ; Sebum ; Skin ; Tetracyclines

Acne vulgaris is a very common condition affecting up of about 80% to 90% of adolescents. The patients with acne have been shown to be adversely impacted by the effect of acne on their quality of life. Four factors are believed to play a key role in the development of acne lesions: excess sebum production, disturbed keratinization within the follicle, colonization of the pilosebaceous duct by Propionibacterium acnes, and the release of inflammatory mediators into the skin. Consequently, the target for acne therapy is these well-known pathogenic factors responsible for this disease state. Topical retinoids correct abnormal keratinization, but it should be applied cautiously because of irritation. Benzoyl peroxide is an effective bactericidal agent against P. acnes. Main topical antibiotics are erythromycin and clindamycin. Fixed combination topical products with retinoids, benzoyl peroxide and antibiotics have been introduced. Use of systemic antibiotics, including tetracyclines and macrolides rapidly improves inflammatory acne lesions. Oral isotretinoin is effective against all of the main pathogenic features of acne but is contraindicated in pregnant women and has been associated with cheilitis and dry skin. Hormonal therapy has been found to improve acne in some selective patients and should be considered for appropriate candidates. This review will present the general aspects of the pharmacological treatments for acne.

Onychomycosis is a relatively common fungal infection. Treatment modalities include oral and topical antifungals, surgical treatment or a combination of these therapies. But treatment failure is common and oral drugs may cause toxicity and potential drug interactions. Currently, there are few publications about the treatment of onychomycosis using photodynamic therapy or laser therapy. We report two cases of toenail onychomycosis treated by 1,064 nm Nd:YAG laser.
Drug Interactions ; Laser Therapy ; Nails ; Onychomycosis ; Photochemotherapy ; Treatment Failure

Oriental medicine is a broad range of medical practices that are based on traditions. These traditions include various forms of herbal medicine, acupuncture, massage, exercise, and dietary therapy. The views of the body place little emphasis on anatomical structures, but are mainly concerned with the identification of functional entities. Recently, most oriental doctors have expanded their range of medical treatment into a variety of aspects, and have introduced treatment remedies that include unproved methods, especially into the field of dermatology. Herein, we present 3 cases of adverse effects following the acupuncture for congenital melanocytic nevus, syringoma, and acne scar in oriental medical clinic. With the increasing popularity of acupuncture, we need to understand the current status of dermatologic treatments conducted in oriental clinics.
Acne Vulgaris ; Acupuncture ; Cicatrix ; Dermatology ; Herbal Medicine ; Hypogonadism ; Massage ; Medicine, East Asian Traditional ; Mitochondrial Diseases ; Nevus, Pigmented ; Ophthalmoplegia ; Syringoma

No abstract available.
Dermatitis* ; Metronidazole* ; Tacrolimus*

BACKGROUND: Filaggrin (FLG) is the major component of the epidermal granular layer and binds to and condenses the keratin cytoskeleton. FLG thus contributes to cell compaction and serves as a natural moisturizing factor by promoting unfolding and degradation into hygroscopic amino acids. Loss or downregulation of FLG has been shown to result in a weak stratum corneum, which causes water loss and increases the possibility of skin barrier-related seizure. Adiponectin (Acrp30) contributes to the functional recovery of somatic cells, including human normal epidermal keratinocytes (NHEKs). OBJECTIVE: To investigate the effect of Acrp30 in FLG expression and identifying its signal transduction mechanism. METHODS: Normal human keratinocytes were treated with Acrp30 and the levels of FLG were examined. Silent mating type information regulation 2 homolog (SIRT)-targeting siRNA and aryl hydrocarbon receptor nuclear translocator (ARNT)-targeting siRNA were used to identify the role of various signal transduction pathway components. RESULTS: Acrp30 upregulated SIRT1 and ARNT expression in NHEKs, resulting in increased FLG expression. Treatment with both SIRT1-targeting siRNA and ARNT-targeting siRNA blocked Acrp30 stimulation and silenced FLG expression. CONCLUSION: Adiponectin upregulates FLG expression through a SIRT1-mediated pathway. Our results suggest that Acrp30 is a promising agent for skin barrier permeability improvement.
Adiponectin* ; Amino Acids ; Aryl Hydrocarbon Receptor Nuclear Translocator ; Cytoskeleton ; Down-Regulation ; Humans* ; Keratinocytes* ; Permeability ; RNA, Small Interfering ; Seizures ; Signal Transduction ; Skin ; Water