A patient who had been complaining of slowly progressive proptosis for two months came to the authors`hospital. Brain MRI was taken promptly to show an intraorbital lesion highly suspicious of schwannoma. We performed an operation in concert with neurosurgeons in which the intraorbital mass was totally resected through orbitozygomatic and extradural approach. After the surgery, ptosis of right upper eyelid and right hypertropia of 22 prism developed as a complication. Another operation was performed 7 months after the initial resection of the mass, in which right inferior rectus muscle was recessed and a silicone sleave was inserted for right frontalis sling. No further complication developed thereafter. Presently, the patient has right hypotropia of 8 prism and only a few creases on right upper eyelid. Orbital schwannoma is a rare disease and comprises approximately 1 percent of all orbital tumors. The authors experienced postoperative double elevator palsy as well as sinus and intraorbital schwannoma. We report this case with review of the literature.
Brain ; Cavernous Sinus* ; Elevators and Escalators* ; Exophthalmos ; Eyelids ; Humans ; Magnetic Resonance Imaging ; Neurilemmoma* ; Orbit* ; Paralysis* ; Rare Diseases ; Silicones ; Strabismus

No abstract available.

No abstract available.
Nevus, Intradermal

No abstract available.
Hair Removal*

No abstract available.
Pregnancy* ; Ultrasonography*

The concentration of hyaluronic acid of rabbit vitreous was investigated after surgical procedures equivalent to intracapsular and extracapsular cataract extraction. Following intracapsular cataract extraction, the concentration of hyaluronic acid decreased significantly (79.0 +/- 55.7 ug/ml), whereas in eyes sujected to extracapsular cataract extraction, hyaluronic acid concentration was not significantly decreased(167.7 +/- 53.8 ug/ml).
Cataract Extraction ; Cataract* ; Hyaluronic Acid*

Aconite is a common remedy of herb doctors and is widely used in the Far East. Clinical aspects of the visual disturbance produced by this drug have been described, but little is known about its pathology. Tinctura aconiti (0.6 mg of total alkaloid/kg 2x) was administered intraperitoneally in rabbits to evaluate its toxic effects on the visual system. The alteration in the visual evoked potential following aconite injection consisted of a delay in the onset and peak latency. Histopathologically, there were damages to the myelin sheath of the visual pathway, spinal cord and peripheral nerves. These findings suggest that aconite may cause primarily myelo-optic neuropathy.
Aconitum/administration & dosage/*toxicity ; Animals ; Evoked Potentials, Visual/*drug effects ; Injections, Intraperitoneal ; Myelin Sheath/*drug effects/ultrastructure ; Optic Nerve/*drug effects/ultrastructure ; Optic Nerve Diseases/*chemically induced/pathology ; Rabbits ; Spinal Cord/*drug effects/ultrastructure

Onychomycosis is a relatively common fungal infection. Treatment modalities include oral and topical antifungals, surgical treatment or a combination of these therapies. But treatment failure is common and oral drugs may cause toxicity and potential drug interactions. Currently, there are few publications about the treatment of onychomycosis using photodynamic therapy or laser therapy. We report two cases of toenail onychomycosis treated by 1,064 nm Nd:YAG laser.
Drug Interactions ; Laser Therapy ; Nails ; Onychomycosis ; Photochemotherapy ; Treatment Failure

Oriental medicine is a broad range of medical practices that are based on traditions. These traditions include various forms of herbal medicine, acupuncture, massage, exercise, and dietary therapy. The views of the body place little emphasis on anatomical structures, but are mainly concerned with the identification of functional entities. Recently, most oriental doctors have expanded their range of medical treatment into a variety of aspects, and have introduced treatment remedies that include unproved methods, especially into the field of dermatology. Herein, we present 3 cases of adverse effects following the acupuncture for congenital melanocytic nevus, syringoma, and acne scar in oriental medical clinic. With the increasing popularity of acupuncture, we need to understand the current status of dermatologic treatments conducted in oriental clinics.
Acne Vulgaris ; Acupuncture ; Cicatrix ; Dermatology ; Herbal Medicine ; Hypogonadism ; Massage ; Medicine, East Asian Traditional ; Mitochondrial Diseases ; Nevus, Pigmented ; Ophthalmoplegia ; Syringoma

OBJECTIVETo investigate the association between pulmonary vascular remodeling and expression of hypoxia-inducible factor-1α (HIF-1α), endothelin-1 (ET-1) and inducible nitric oxide synthase (iNOS) in pulmonary vessels in neonatal rats with hypoxic pulmonary hypertension (HPH).

METHODSA neonatal rat model of HPH was established as an HPH group, and normal neonatal rats were enrolled as a control group. The mean pulmonary arterial pressure (mPAP) was measured. The percentage of medial thickness to outer diameter of the small pulmonary arteries (MT%) and the percentage of medial cross-section area to total cross-section area of the pulmonary small arteries (MA%) were measured as the indicators for pulmonary vascular remodeling. The immunohistochemical reaction intensities for HIF-1α, ET-1 and iNOS and their mRNA expression in lung tissues of neonatal rats were measured. Correlation analysis was performed to determine the relationship between pulmonary vascular remodeling and mRNA expression of HIF-1α, ET-1 and iNOS.

RESULTSThe mPAP of the HPH group kept increasing on days 3, 5, 7, 10, 14, and 21 of hypoxia, with a significant difference compared with the control group (P<0.05). The HPH group had significantly higher MT% and MA% than the control group from day 7 of hypoxia (P<0.05). HIF-1α protein expression increased significantly on days 3, 5, 7 and 10 days of hypoxia, and HIF-1α mRNA expression increased significantly on days 3, 5 and 7 days of hypoxia in the HPH group compared with the control group (P<0.05). ET-1 protein expression increased significantly on days 3, 5 and 7 days of hypoxia and ET-1 mRNA expression increased significantly on day 3 of hypoxia in the HPH group compared with the control group (P<0.05). Both iNOS protein and mRNA expression were significantly higher on days 3, 5 and 7 days of hypoxia than the control group (P<0.05). Both MT% and MA% were positively correlated with HIF-1α mRNA expression (r=0.835 and 0.850 respectively; P<0.05).

CONCLUSIONSPulmonary vascular remodeling is developed on day 7 of hypoxia in neonatal rats. HIF-1α, ET-1 and iNOS are all involved in the occurrence and development of HPH in neonatal rats.

Animals ; Animals, Newborn ; Endothelin-1 ; analysis ; physiology ; Hypertension, Pulmonary ; etiology ; metabolism ; pathology ; Hypoxia ; complications ; Hypoxia-Inducible Factor 1, alpha Subunit ; analysis ; physiology ; Immunohistochemistry ; Nitric Oxide Synthase Type II ; analysis ; physiology ; Pulmonary Artery ; chemistry ; pathology ; Rats ; Rats, Wistar