OBJECTIVE:To optimize formula for the compound naftifine hydrochloride cream and to study the stability of its finished products.METHOD:The dosage of the hexadecanol,octadecanol,S-40and sodium dodecyl sulfate was taken as variable factor,the orthogonal experimental design method was adopted and L 9 (3 4 )table was chosen for the experiment.RE-SULTS:The optimized formula is composed of4%of hexadecanol,2%of octadecanol,6%of S-40and0.1%of sodium do-decyl sulfate,from which the finished products manufactured had good stability.CONCLUSION:The cream prepared from this optimized formula and method can meet the specification stated in Chinese Pharmacopoeia.

OBJECTIVE:To optimize the best formulation and process of acitretin capsule and to study the stability of its finished preparation.METHODS:The orthogonal experiment was conducted with the formula quantity of amylum pregela?tinisatum,lactose and low-substituted hydroxypropyl cellulose(L-HPC)as the determination factors,the comprehensive e?valuation was conducted with dissolution rate,flowability,content uniformity and so on as the quality determination index of finished preparation;The stability of the finished preparation was determined under illumination,high temperature and high-moisture.RESULTS:The best formulation was composed of the following,amylum pregelatinisatum20%,lactose20%,L-HPC1%,which was prepared by granulating process;The finished preparation was stable in quality.CONCLUSION:The optimized formulation and technics of acitretin capsule were reasonable and the dissolution,content uniformity and stability of the finished preparation from which were in conformity with China Pharmacopoeia.

OBJECTIVE: To provide references on the development of soybean isoflavones products for Chinese enterprises and research institutions of pharmacy.METHODS: Both domestic and abroad markets of soybean isoflavones and the exploitation status quo of which were analyzed in detail.RESULTS & CONCLUSION: Soybean isoflavones is worthy to be exploited and the market for which is very broad.

At the important position of the basic medical education,clinical practice and scientific research,scientific research of university affiliated hospital plays a crucial role in promoting national progress of medicine in the process of national disease prevention and the healthy level of prevention,treatment,care promotion.Under the science and technology plan management reform and innovation driven development strategies of the top-level design,one of the most important tasks of the discipline inspection and supervision work of hospitals in the new era is to explore how to strengthen the supervision and administration of scientific research,how to construct the scientific research work independent risk control system and how to empower university hospital research development.

BACKGROUND:K-wire and steel wire tension band wiring is the most commonly method for the treatment of patel ar fracture. However, there have been many reports of complications related to the mental implants. Based on the reasons above, some scholars begin to replace the steel wire with braided polyester sutures for the treatment of patel ar fracture. OBJECTIVE:To observe the effect of patel ar ring pins and FiberWire braided polyblend sutures tension band fixation for treatment of patel ar fracture. METHODS:We performed a retrospective analysis involving 26 patients with patel ar fracture (16 males, 10 females, at the age of 36-54 years with a mean age of 44.6 years) who were treated with patel ar ring pins and FiberWire braided polyblend sutures tension band fixation. RESULTS AND CONCLUSION:Al the patients were fol owed-up for 6-18 months, average of 12 months. Al patients were primary healing and achieved bone union in 8-16 weeks, averaged in 12 weeks from surgery. There was no fracture fragment displacement, internal fixation loosening and break. No pins protruding from the subcutaneous and irritate the skin. According to the Lysholm&Gil quist scales, 18 cases were excellent, four cases were good, and four cases were fair, with the excellent and good rate of 85%. Tension band fixation using patel ar ring pins and FiberWire braided polyblend sutures resulted in good outcomes with few complications.

Aged ; Anemia, Hemolytic, Autoimmune ; complications ; Female ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; complications

Chemokine CXCL12 ; Child ; Humans ; Neoplasm Metastasis ; Neoplasms ; pathology ; Receptors, CXCR4

Traditional theories on information management have made an extreme of studies and practice on medical informatics, which has hampered the development of medical informatics. Knowledge management is a brand new theory based on information and aiming at innovation of knowledge, and is in accordance with the nature of medical informatics. Medical informatics based on knowledge management promotes management of medical information, which not only benefits the integration and development of disciplines of medical informatics, also benefits hospital informatization, implementation of evidence-based medicine, and education in medical informatics. Basic studies on medical informatics, personnel training and management should be guided by knowledge management theory in the field of informatics.

Objective To investigate the therapeutic effect of minimally invasive percutaneous nephrostolithotomy (mPCNL) in treatment of kidney calculi and the influence of renal function.Methods According to the operation method,70 patients with kidney calculi were divided into mPCNL group (38 patients) and percutaneous nephrostolithotomy (PCNL) group (32 patients).The curative effect,serum creatinine (SCr) and blood urea nitrogen (BUN) postoperative 1 month were compared.Results The patients in two groups were successfully for broken calculi.The operation time of stag-horn calculi,retinitis simplex kidney pelvis calculi and kidney calices multiple calculi in PCNL group were significantly shorter than those in mPCNL group [(89.13 ± 13.36) min vs.(112.32 ± 12.41) min,(65.28 ±9.76) min vs.(78.84 ± 12.03) min,(98.97 ± 11.84) min vs.(112.64 ± 10.87) min,P ＜ 0.05].The first stage clearance rate of retinitis simplex kidney pelvis calculi in PCNL group was significantly higher than that in mPCNL group [88.89％(8/9) vs.57.14％(8/14),P ＜ 0.05].But the clearance rate of kidney calices multiple calculi in PCNL group was significantly lower than that in mPCNL group [58.33％(7/12) vs.86.67％(13/15),P＜0.05].The first stage clearance rate of stag-horn calculi in two groups had no significant difference [63.64％(7/11) vs.66.67％ (6/9),P ＞ 0.05].The patients in two groups had no serious complication.The rate of fever after operation in two groups had no significant difference [15.63％ (5/32) vs.10.53％ (4/38),P ＞ 0.05].The level of SCr and BUN in the patients combined with kidney insufficiency in two groups were decreased slightly (P ＞ 0.05).The improvement rate of renal function in two groups had no significant difference (P ＞0.05).Conclusions mPCNL and standard channel PCNL in treatment of kidney calculi can achieve a good first stage clearance rate,and the incidence rate of postoperative complication is lower.mPCNL and standard channel PCNL have no obviously influence on early stage renal function.The operation time of mPCNL is generally longer,but the therapeutic effect of kidney calices multiple calculi is better than standard channel PCNL.

Objective: To summarize the experience in the treatment of candidiasis albicans. Methods: 95 cases aged 5 months～78 years old with candidiasis albicans were treated by fluconazole and polyactin A etc, the Candida albicans were examined by smear examination.Results: The rate of cure was 35.79 %, that of improvement was 57.89%, the clearance rate of Candida albicans was 80.59%.Conclusion: The Cadida albicans is opportunistic pathogen. Fluconazole is effective in the treatment of candidiasis albicans.