1.Atrial remodeling and atrial fibrillation:recent advances and translational perspectives
Chinese Journal of Geriatrics 2016;35(5):560-564
Atrial fibrillation (AF) is the most common clinical arrhythmia.Atrial electrical remodeling and structural remodeling are the important mechanisms for AF.The intracellular Ca2+ handling abnormalities play an important role in the induction of triggered ectopic activity and in the activation of Ca2+-related cell signaling which mediates fibrillatory remodeling.In addition,the importance of microRNAs,which are a new class of small noncoding sequences that regulate gene expression,has been found in both electrical and structural remodeling.The new discovery of AF mechanisms are helpful to exploring the effective treatment for AF,showing good prospects for the use of translational perspectives.
3.Recent progress in short QT syndrome.
Kui HONG ; Hai SU ; Xiao-shu CHENG
Chinese Journal of Cardiology 2006;34(9):858-860
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Arrhythmias, Cardiac
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diagnosis
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genetics
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therapy
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Child
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Child, Preschool
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Electrocardiography
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Humans
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Infant
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Male
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Middle Aged
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Syndrome
4.The effect of polyactin A and/or Zhongtong’an in the treatment of recurrent aphtha ulceraiton
Hong XU ; Kui SU ; Shufan LIU
Journal of Practical Stomatology 1995;0(04):-
0.05;1 or 2 vs 3,P
7.The clinical study of candidiasis albicans
Kui SU ; Hong XU ; Shufan LIU
Journal of Practical Stomatology 2001;0(03):-
Objective: To summarize the experience in the treatment of candidiasis albicans. Methods: 95 cases aged 5 months~78 years old with candidiasis albicans were treated by fluconazole and polyactin A etc, the Candida albicans were examined by smear examination.Results: The rate of cure was 35.79 %, that of improvement was 57.89%, the clearance rate of Candida albicans was 80.59%.Conclusion: The Cadida albicans is opportunistic pathogen. Fluconazole is effective in the treatment of candidiasis albicans.
8. Nitrogenous chemical constituents from Carthamus tinctorius
Chinese Traditional and Herbal Drugs 2014;45(21):3071-3073
Objective: To study the chemical constituents from flowers of Carthamus tinctorius. Methods: The chemical constituents were isolated and purified by multiple chromatographic methods. Their structures were identified on the basis of spectral data and physicochemical properties. Results: Ten compounds were identified as l-phenylalanine (1), thymine (2), inosine (3), guanosine hydrate (4), thymidine (5), 2'-O-methyluridine (6), banegasine (7), adenosine (8), 2'-deoxyadenosine (9), and 5'-deoxy-5'- methylamino-adenosine (10). Conclusion: Compound 3, 5, 6, 9, and 10 are isolated from this plant for the first time.
9.Application of Induced Pluripotent Stem Cells in Experiment Study of Hereditary Heart Disease (review)
Yunguo ZHOU ; Lingling CAO ; Kui HONG
Chinese Journal of Rehabilitation Theory and Practice 2012;18(11):1047-1048
The establishment of induced pluripotent stem (iPS) cells is considered as one of the most important progresses in science and technology nowadays. In recent years, the iPS cells have been used in the construction of cellular model for hereditary heart disease, and the successful treatment in animal model of myocardial infarction, which brings a bright future for exploring the pathogenesis and therapy of hereditary heart disease.
10.Effect of Cold Stress on Connexin43 Protein Expression With Drug Intervention in Neonatal Rats’ Myocardial Cells
Qianghui HUANG ; Kui HONG ; Xiaoshu CHENG ; Jianxin HU
Chinese Circulation Journal 2015;(1):59-63
Objective: To study the effects of acute cold stress on connexin43 (Cx43) protein expression with drug intervention, and cell to cell conduction with its mechanism in neonatal rats’ myocardial cells.
Methods: The primary neonatal rats’ myocardial cell culture was conducted in 4 groups. Group① , the cells were normally cultured, Group②, the cells were cultured at 4℃, Group③, the cells were cultured at 0℃and Group④, the anti-arrhythmia peptide (AAP 10) was added in Group②and Group③. The apoptosis rate of myocardial cells was evaluated by lfow cytometry assay, mRNA and protein expressions of CX43 were examined by RT-PCR and Western blot analysis, and CX43 phosphorylation product (P-CX43) was detected.
Results: Compared with normally cultured cells, the myocardial cell apoptosis rate was obviously increased by acute cold stress at 4℃and 0℃with time extension. The mRNA expression of Cx43 was decreased at varying degrees at 4℃and 0℃stimulation, the protein expression of Cx43 was decreased at varying degrees at 4℃and 0℃stimulation with time extension, and P-Cx43 level was decreased. While the APP 10 intervention may obviously elevate the protein levels of Cx43 and P-Cx43.
Conclusion: Acute cold stress could reduce the protein expression of CX43 and P-CX43, while APP 10 intervention may elevate such expression and improve the cell to cell conduction in neonatal rats’ myocardial cells.