No abstract available.
Alcoholics* ; Ego* ; Humans

No abstract available.
Anencephaly* ; Humans ; Pregnancy, Twin* ; Twins*

PURPOSE: To study whether preoperative fasting would influence postoperative prognosis and to measure the variation of the ketone body amount and ketone body ratio, kidney function during the postoperative period in the model of 90% hepatectomy. MATERIALS AND METHODS: Total of 180, seven weeks old, male, specific pathogen free Sprague-Dawley rats, divided into two groups of the fasted and the fed. First, 80 rats were divided into two groups of 40 each; 40 of that were denied food for 48 hours before the operation, other 40 were fed. Following 90% hepatectomy they were investigated by Kaplan-Meier method, drawing a survival curve. Secondly, 100 rats were divided into two groups of 50 each, 50 of that were denied food for 48 hours before the operation, and the other 50 were fed. Following 90% hepatectomy, they were investigated by the method of Student's T-test and Mann-Whitney test on the following: the amount of arterial ketone body in the blood in the blood sampled from abdominal aorta, reading at preoperative 48 hours, at the time of operation, postoperative 6 hours, 12 hours, 24 hours, 48 hours periods. RESULTS: The mean survival time after operation: the fasted group was 53.0+/-3.7 hours and the fed group was 34+/-1.7 hours and it had the statistical significance(p=0.0008). Rats which had long term survival over 72 hours were 14(35%) in fasted group, but only 2(5%) in fed group. In preoperative fasted group arterial ketone body ratio was recovered earlier than fed group and ketone body amount elevated, but in preoperative fed group, there was no significant change in ketone body amount. Blood glucose level lowered in both groups. Blood ammonia was severely increased in preoperative fed group, suggested bad liver function and destruction of muscle. BUN and blood creatinine was elevated in preoperative fed group, suggested lowered kidney function. CONCLUSION: Preoperative fasting has a positive influence on survival of the rats which has acute liver failure induced by 90% hepatectomy, because it could be caused by increased ketone body amount by preoperative fasting.
Ammonia ; Animals ; Aorta, Abdominal ; Blood Glucose ; Creatinine ; Fasting* ; Hepatectomy* ; Humans ; Kidney ; Liver ; Liver Failure ; Liver Failure, Acute ; Male ; Postoperative Period ; Prognosis ; Rats* ; Rats, Sprague-Dawley ; Specific Pathogen-Free Organisms ; Survival Rate

No abstract available.
Humans ; Organophosphate Poisoning* ; Respiratory Insufficiency*

PURPOSE: Theophylline, an adenosine antagonist commonly used in premature infants to treat apnea, has been shown to decrease erythropoietin levels in adults. We studied the effect of theophylline on serum erythropoietin levels in premature infants with apnea. METHODS: Subject were 12 premature infants with apnea who were admitted to the NICU, Chosun University Hospital. The first dose of theophylline was 5mg/kg, given intravenously, followed by 1 to 2mg/kg per day. Serum levels were maintained between 5 and 12microgram/dl with dosage adjustments. Erythropoietin, hemoglobin, hematocrit, reticulocyte count, erythrocyte indices were obtained on the last day of theophylline treatment and again 1 week later. Erythropoietin levels were determined by radioimmunoassay. Blood transfusions were avoided a week before and during the study period. RESULTS: 1) Hemoglobin and hematocrit levels were decreased at 1 week after the discontinuation of theophylline treatment compared to the last day of theophylline treatment (P<0.05), but reticulocyte count (%) was increased (P<0.05). 2) There was a significant increase in serum erythropoietin levels from 3.31+/-1.53u/l to 6.68+/-2.41u/l (P<0.05). 3) No correlation was found between erythropoietin levels and the number of days on respirator, the number of days of O2 supply, the number of apneic episodes, the number of blood transfusion, the period of theophylline treatment and the theophylline blood levels. CONCLUSIONS: We suggest that prolonged treatment with theophylline might reduce erythropoietin production in premature infants.
Adenosine ; Adult ; Apnea ; Blood Transfusion ; Erythrocyte Indices ; Erythropoietin* ; Hematocrit ; Humans ; Infant, Newborn ; Infant, Premature* ; Radioimmunoassay ; Reticulocyte Count ; Theophylline* ; Ventilators, Mechanical

PURPOSE: Chromosomal aberration has an effect on the lives of both patients and families. Peripheral blood chromosomal analysis is useful to make a diagnosis and counsel the patient with chromosomal abnormality. We studied the cases with peripheral blood chromosomal analyses and investigated the positivity of peripheral blood chromosomal analysis. METHODS: We analyzed 650 patients with chromosomal analyses in Ajou University Hospital during the past 10 years. We used a high-resolution banding technique to diagnose the chromosomal aberrations. RESULTS: The male to female ratio of the patients was 1.1 : 1. Among 650 patients, 108 patients had chromosomal aberrations(16.6%). Fifty seven out of 313 patients with the congenital anomalies or dysmorphologies had chromosomal aberrations. twenty six out of 166 patients with hematologic disorders had chromosomal aberrations. Fifteen out of 109 patients with developmental delay had chromosomal aberrations. Four out of 24 patients with seizures had chromosomal aberrations. Six out of 39 patients with the aberrant perinatal histories had chromosomal aberrations. CONCLUSION: Peripheral blood chromosomal analysis is an important diagnostic method in managing patients with chromosomal aberrations. Further advanced chromosomal staining and molecular genetic methods will raise the detection rate of chromosomal aberration and be useful in managing patients with chromosomal abnormalities.
Chromosome Aberrations ; Diagnosis ; Female ; Humans ; Male ; Molecular Biology ; Seizures

Purpose: The goal of this study is to define whether or not preoperative portal vein embolization has any additional role in the total amounts of liver regeneration and functional improvement after major hepatectomy in rat model. In addition, this study is to define obstructive jaundice has any positive or negative effect on it. METHODS: There were a total of 650 rats, divided into three experimental groups. Experiment A was done under the normal liver status, experiment B was done under the obstructive jaundice status, experiment C was done under the external biliary drainaged status. Each experimental group was divided into three groups that had been made by different surgery. One was 70% partial hepatectomy, another was 70% portal vein branch ligation, and the other was 70% portal vein ligation followed by 70% hepatectomy. Each operational group required over 60 rats for serial data collection which was taken at the operation and 6, 12, 24, 48, 72 hours after operation. RESULTS: We finally observed that there was no additional regeneration of remaining liver by doing preoperative portal vein embolization. It was same in obstructive jaundice group and external biliary drainaged group. And also, there was no significant fucntional improvement or deterioration by existence of obstructive jaundice. Conclusion: We conclude it is no worth doing preoperative portal vein embolization for getting additional liver regeneration and obstructive jaundice does not has significant positive or negative effect on liver regeneration and hepatic function in itself.
Animals ; Data Collection ; Hepatectomy ; Jaundice* ; Jaundice, Obstructive ; Ligation* ; Liver Regeneration ; Liver* ; Models, Animal ; Portal Vein* ; Rats* ; Regeneration*

The Korean Agricultural Culture Collection (KACC) has developed a web-based system to provide an integrated database with information updates about microbial resources. This integrated database consists of 5 major functions and contains general information, which includes identification numbers, culture media composition, image information, DNA sequences, patent information, and general forms for ordering and depositing microorganisms. In 2008, KACC started providing characterization information. KACC maintains 9,801 cultures of microorganisms, including 3,296 strains of bacteria, 4,734 fungi, 784 actinomycetes, 64 yeasts, and 923 others.
Actinobacteria ; Bacteria ; Base Sequence ; Culture Media ; Fungi ; Yeasts

Herpes zoster, an inflammatory human disease caused by varicella zoster virus, is characterized by papulovesicular lesions along the distribution of a sensory nerve. We experienced a herpes zoster in 23 day old premature infant. The papules were distributed on his skin corresponding to the dermatomes innervated by the left Th3-Th4. The diagnosis of herpes zoster was made with dermatomal distribution of typical skin lesions, pathologic findings of eosinophilic intranuclear body and multinucleated giant cells in skin lesion (biopsy specimen). Detection of VZV specific IgG and IgM in the sera of patient was carried out. He was successfully treated with topical and intravenous administration of acyclovir. We report this case with a review of related literatures.
Acyclovir ; Administration, Intravenous ; Diagnosis ; Eosinophils ; Giant Cells ; Herpes Zoster* ; Herpesvirus 3, Human ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Infant, Newborn ; Infant, Premature* ; Skin

PURPOSE: The objective of this study was to analyze the relationship between the electrophysiological studies(EEG and BAEP) and brain ultrasonography and the prognosis of the newborn infants with asphyxia. METHODS: Clinical records, including electrophysiological findings of EEG and BAEP and brain ultrasonography, of 29 term infants with neonatal asphyxia, who had been admitted to the Pediatric Department of Chosun University Hospital between January 1994 and June 1997 were reviewed retrospectively. RESULTS: Out of the 29 cases that returned for follow up, 23 cases were neurodevelopmentally normal, but 6 cases showed delayed development on the Korean Denver Developmental Scale Test(KDDST). Of 19 cases with abnormal EEG findings, 5 showed delayed developrnent on the KDDST(P>0.05). Follow up EEG was performed in 10 cases', 8 of them were normalized, and two remained abnormal without delayed development on the KDDST. Of 8 cases with abnormal brain ultrasonographic findings, 5 showed delayed development on the KDDST(P<0.05). Of 12 with abnormal BAEP findings, 3 showed delayed KDDST(P>0.05). Follow up BAEP was performed in 8 cases, and all cases were normal. CONCLUSION: These results suggest that abnormal findings of EEG and BAEP in the asphyxiated term newborn were reversible, but abnormal brain ultrasonographic findings, especially intracranial hemorrhage, were significantly correlated with delayed development.
Asphyxia ; Brain Stem* ; Brain* ; Electroencephalography* ; Evoked Potentials, Auditory, Brain Stem* ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Intracranial Hemorrhages ; Prognosis ; Retrospective Studies ; Ultrasonography