An 81-year-old man was referred to our hospital with bilateral multiple patchy opacities on chest radiography. His chief complaints were a few months’ history of intermittent mild cough and slightly yellow sputum. Chest computed tomography (CT) showed non-segmental air-space consolidations with ground-glass opacities. Amyloid deposition with organizing pneumonia (OP) was seen in transbronchial lung biopsy (TBLB) specimens from the left S8. Three months later, the infiltration originally seen in the left lower lobe was remarkably diminished, and new infiltrations in the lingual and right lower lobes were detected on chest CT. Amyloid deposition with OP was seen in TBLB specimens from the left S4. Transthyretin was detected following immunohistochemical examination. The presence of wild-type transthyretin (ATTRwt) was proven using genetic analysis. The present report describes a rare case of ATTRwt amyloidosis associated with OP.

  On July 7, 2010, a 74-year-old man came to our hospital, complaining that he had a nagging pain in his chest that started the preceding day. After performing electrocardiography, blood tests and electrocardiography, we diagnosed the case as acute myocardial infarction. At first, it was thought that blood flow could be restored in due course of time, antiplatelet and anticoagulant agents were used. Intracardiac catheterization was not included in our initial treatment plan. Three days after the initiation of the treatment, the patient had pain in his left inguinocrural region. Computed tomography and magnetic resonance imaging reveled hematoma in his left iliopsoas muscle. We stopped administering antiplatelet and anticoagulant agents to him. But anemia progressed from Hb14.1g/dL to 9.8 g/dL, so blood transfusions had to be given. After that, the patient underwent a rest cure. With the passage of time, the pain and swelling of the left iliopsoas muscle went down. Regarding the cardiac condition, however, the pain in the chest did not abate even when he was taking a rest. The antiplatelet therapy was resumed, with one type of agent given at first and then with another type added. Examinations using a coronary CT and a cadiac catheter found 90% stenosis at the proximal left anterior descending coronary artery. So, a bare metal stent was placed in the near-closed artery. Ever since, there has been no recrudescence of chest pain and no recurrence of iliopsoas muscle hematoma. The extravascated blood mass seemed to be dissolved spontaneously.

No abstract available.
Lymphoma, T-Cell* ; T-Lymphocytes*

Objective:It is necessary to obtain appropriate drug information (DI)so that appropriate medical care is provided for the consumers,patients. Thorough studies have not been done on institutions that offer DI for patients in Japan and the state of its dissemination. The purpose of this study is to find levels of recognition of the institutions providing medical information and the actual state of its usage.Method:In order to find the levels of recognition of the institutions that provide DI to general consumers and the state of usage of the information provided by them,we conducted questionnaire surveys using online panels. We also conducted a study to find subjective comprehension on DI by the panels. The surveys were conducted twice using the same questionnaire in order to robust the outcomes of the study.Results:We received 1,095 valid responses from the first survey and 1,086 from the second survey respectively. No significant differences were found between the two surveys. Although the levels of recognition vary for the four representative public institutions providing DI,DI provided by these institutions has been barely utilized by the respondents. As the sources of DI that have been used most,almost the same numbers of respondents replied that they used Internet search engines to access them in addition to medical doctors and pharmacists. Regarding the levels of comprehension for the provided DI,the respondents tended to have shown high levels of understanding on maintaining medication compliance,but low on safety information. There was a positive correlation between age and the understanding of the DI.Conclusion: The study implies that the environment to provide DI for patients still needs to be improved, and the respondents didnʼt understand DI enoughly. Therefore,it is necessary to study further for the creation and communication of truly user-friendly DI.

Drug Evaluation, Preclinical ; methods ; Humans ; Intracellular Signaling Peptides and Proteins ; metabolism ; Protein Binding ; drug effects ; Small Molecule Libraries ; chemistry ; pharmacology ; Transcription Factors ; metabolism ; Tumor Suppressor Proteins ; metabolism