We report a pair of atypical rhomboideus muscles which originated higher than normal observed in a 49-year-old Korean male. Rhomboid muscles were not paralleogram shape but trapezoid with rhomboideus tertius attached inferior to the rhomboideus major muscles. Rhomboideus minor originated as tendon from the ligamentum nuchae of fourth and sixth cervical vertebrae level. The upper end of the origin of the rhomboideus major was the ligamentum nuchae between fifth and sixth cervical vertebrae level on the left side and the ligamentum nuchae at the sixth cervical vertebra level on the right side. The lower end of the origin of the rhomboideus major was the spinous process of the fourth thoracic vertebra on the left side and the spinous process of the second thoracic vertebra on the right side. The upper end of the origin of the rhomboideus tertius were the same as the lower end of the rhomboideus major and the lower end of the origin of the rhomboideus tertius were the spinous process of the fifth thoracic vertebrae on both sides. Whole rhomboideus muscle spanned over nine vertebrae. We compared these rhomboidei with previously reported variations and discussed its embryological and clinical significance.
Cervical Vertebrae ; Female ; Humans ; Male ; Middle Aged ; Muscles* ; Spine ; Tendons ; Thoracic Vertebrae

The most essential biological profiles in physical and forensic anthropology are age, sex, and populations to be determined. In case of dealing intact skeletons, experts can often determine sex with high accuracy. The external occipital protuberance (EOP) is one of the site among morphologic traits which is used to determine human sex. This study suggests the possibility to determine the sexual dimorphism using the EOP and surrounding anatomical structures in Koreans. After three-dimensional reconstruction of the skull model from Digital Korean Human Databse, the three parts were evaluated using a classification system based on Broca, Gulekon and Turgut. To determine for scoring, this study was used two in two different ways to observe the skull model; one was a lateral view and the other was turning the skull models. In a lateral view, the shape of the occipital area was classified as 'flat' or 'convex' type. After then the scores of the anatomical structures were converted into 4-digits code. In females, the skull was more convex in shape than males but the EOP and inion were lesser projection. In the lateral and turning views, the most common pattern was Type 2 in both sexes. The most common digit code was 2-2-2-0 in males, 2-2-2-1 in females. The digit code is better than simple scoring system for determining sex. The skull in Koreans were more feminine than in other populations in both sexes.
Classification ; Female ; Forensic Anthropology ; Humans ; Male ; Skeleton ; Skull

Angiogenesis is the fundamental biological phenomenon in the development of vertebrates and various pathophysiological process such as cancer, inflammation and wound healing. Thrombospondin-1 is a well-known anti-angiogenic molecule which is distributed in the extracellular matrix of various tissues. The second and third type I repeats of human TSP-1 have inhibitory effects on endothelial cell migration and induce angiogenesis inhibition. However the role of the first type I repeat was not elucidated. In addition, the first type I repeat of bovine TSP-1 has CSVTCG amino acid sequence which is known to have anti-angiogenic activity. In the present study, we compared the inhibition of angiogenesis to investigate the role of the first type I repeat of the human and bovine TSP-1. Matrigel was mixed with or without TSR-1 peptides and then injected into C57BL/6J mice. We compared angiogenesis inhibition activity by hemoglobin assay, microvessel density and optical density value after 7 days. Furthermore, inhibition of angiogenesis was confirmed on CAM assay by TSR-1 peptides. For in vitro angiogenesis assay, TSR-1 peptides were treated on the proliferation, migration, and tube formation assay of HUVEC. Apoptosis effect of TSR-1 peptides was confirmed by apoptosis assay kit and flow cytometry. Bovine and human TSR-1 peptides blocked neovascularization in in vivo Matrigel plug assay and CAM assay at 10 microM. Bovine TSR-1 peptides have shown stronger angiogenesis inhibition in bFGF-induced angiogenesis than human TSR-1 and CSVTCG peptides. However, all of TSR-1 peptides inhibit migration and tube formation of HUVEC in in vitro. Furthermore, these peptides also induced apoptosis of HUVEC. These results suggest that TSR-1 peptides of bovine and human TSP-1 have angiogenesis inhibition activity.
Amino Acid Sequence ; Animals ; Apoptosis ; Biological Phenomena ; Endothelial Cells ; Extracellular Matrix ; Flow Cytometry ; Humans ; Inflammation ; Mice ; Microvessels ; Peptides* ; Thrombospondin 1 ; Vertebrates ; Wound Healing

Cadaver dissection is an effective method for learning structure and function of the human body. However, division of health science is conducting an anatomy lecture lean toward theory because it is impossible to operate their own practice program. This study was performed to propose a customized anatomy practice program plan that reflects needs of students majoring dental hygiene. A survey was conducted to 138 students majoring dental hygiene at D university. We used a structured questionnaire to analyze general characteristics of a subject, opinions about cadaver dissection, educational method and the demands of a program. Then we acquired frequency, mean, standard deviation, and correlation coefficient value. Furthermore, we also performed independent t-test and variance analysis (ANOVA) by using R program (version 3.2.2). A majority of students responded positively in items of necessity, satisfaction and comprehension of cadaver dissection. Dissection using cadaver marked a highest response (48.6%) among the methods of anatomic education. As for an appropriate time required for education, 72 students (52.2%) responded 30 minutes for an orientation time and 46 students (33.3%) for an observation time. Students also responded head and neck area and skeletal system to be the top priority for observation. In order to operate systemic cadaver dissection program, practical institutions should provide an active system. Contents of a necessity and procedure of cadaver donation should be included in preliminary education, with a thoughtful consideration to minimize negative psychological response of students during educational process. In observation, we should organize program focused on head and neck region and a three-dimensional structure of skeletal system. We expect our study to provide useful information in composing cadaver dissection program for dental hygiene students in the future.
Cadaver* ; Comprehension ; Education ; Head ; Human Body ; Humans ; Learning ; Neck ; Oral Hygiene*

The aim of this study was to classify morphological patterns of the lumbrical muscles and their anatomical variations in the hands. The lumbricals in the hand were investigated in 70 specimens of 45 embalmed Korean adult cadavers. The shapes of the lumbrical muscles were observed in 70 specimens and the distances from the distal border of the flexor retinaculum to the origins of the lumbricals were measured using digital calipers in 52 specimens. The lumbrical muscles were classified into 3 types based on their shapes, and also into 10 types based on their insertion sites. The average distances from the distal border of the flexor retinaculum to the origins of the first, second, third, and fourth lumbricals were +1.8 mm, - 1.4 mm, +5.1 mm, and +11.2 mm, respectively. The results of this study could be useful information for better understanding the function of the lumbrical muscles and for various types of diagnoses and surgery involving the hands.
Adult ; Cadaver ; Diagnosis ; Hand* ; Humans ; Muscles*

The 2nd to 4th digit ratio (2D : 4D) reflects exposure level of sex hormones in fetal period. The aim of this study is to identify a change of digit ratio according to age and a critical age showing gender difference in Korean children. This study was done on 1,182 children (588 males, 594 females). Data were collected by measuring index and ring finger length on both hands by photocopy. The data were analyzed using SPSS win 21.0. This study showed that the 2nd and 4th finger length and digit ratio of both hands increased with age both male and female. There was no differences in 2nd to 4th digit ratio between males and females until they were 3 years old. However, there were significant differences in 2nd to 4th digit ratio between males and females from the age of four. The results suggest that digit ratio in Korean children increases with age and a critical age showing gender difference is from the age of four.
Child* ; Female ; Fingers ; Gonadal Steroid Hormones ; Hand ; Humans ; Male

This morphometric study of the trachea was performed to provide the basic data necessary for shielding crico-thyroid membrane incision, tracheal intubation and tracheotomy in korean bodies 48 (33 male, 15 female). Tracheal measurement included the number, the length, the anteroposterior and transverse diameters of trachea, and the height of tracheal cartilages, and the inter-rings distances of cartilages. The length of trachea was 104.0+/-1.4 mm in male and 102.3+/-1.9 mm in female, but there was no significance between males and females. All of the anteroposterior and transverse diameters, and the height were longer in males, compared with females, in the first, fifth, tenth and fifteenth tracheal cartilages. The anteroposterior and transverse diameters of the first and fifteenth tracheal rings, and the height of the first tracheal ring differed significantly male's from female's. The distances between posterior end of rings of the first, tenth and fifteenth tracheal cartilages were broader in males. The inter-rings distances of tracheal cartilage were also wider in the male, and showed significant differences in the 1st~2nd and 10~11th. These results suggest that this might be useful as a clinical basic data for the emergency physician, anesthetist, and associated medical doct
Cadaver ; Cartilage ; Emergencies ; Female ; Humans ; Intubation ; Male ; Membranes ; Trachea* ; Tracheotomy

Thrmobospondin-1 is the multifunctional protein that modulates endothelial cell and tumor cell behavior via several cell surface receptors and inhibits angiogenesis. In vitro, thrombospondin-1 alters adhesion, proliferation, motility, and survival of endothelial and cancer cells. Studies have confirmed that increased TSP-1 expression suppresses growth or metastasis of some tumors and inhibits angiogenesis. In the past three decades, inhibitors of angiogenesis have been developed as regulators target the vascular endothelial growth factor (VEGF) signaling pathway and small molecule tyrosine kinase inhibitors have been clinically approved. TSP-1 has several functional domain structures and inhibits tumor angiogenesis by engaging receptors CD36 and CD47. TSP-1 binding to CD47 dissociates it from VEGFR2, inhibiting downstream AKT activation and functional responses of endothelial cells to VEGF. Recently, macrophage phagocytosis and cytotoxic T-cell induction of tumor cells mediated by CD47-specific blocking antibodies have been proposed. These findings provide a new therapeutic paradigm for elinination of cancer cells and inhibition of angiogenesis of tumor by TSP-1.
Antibodies, Blocking ; Endothelial Cells ; Macrophages ; Neoplasm Metastasis ; Phagocytosis ; Protein-Tyrosine Kinases ; Receptors, Cell Surface ; T-Lymphocytes ; Thrombospondin 1 ; Vascular Endothelial Growth Factor A

No abstract available.

No abstract available.
Adipose Tissue* ; Bone Density* ; Female ; Humans ; Middle Aged*