Hemangiopericytoma is a rare mesenchymal neoplasm, accounting for about 1% of vascular tumor. Hemangiopericytoma is known to be derived from the vascular pericyte and occurs most commonly lower extremities, pelvis and retroperitoneum. Surgical radical excision is the treatment of choice. Because of malignant features of hemangiopericytoma, long term and close follow-up is important. We report a case of successfully resected retroperitoneal hemangiopericytoma.
Accounting ; Follow-Up Studies ; Hemangiopericytoma ; Lower Extremity ; Pelvis ; Pericytes

Primary broad ligament tumors are a rare entity, although secondary involvement of broad ligament by a malignancy arising elsewhrere in the abdomen/pelvis is common. Among the primary broad ligament tumors, leiomyoma is the most frequent histopathological type followed by serous papillary cystadenoma of borderline malignancy. Primary sarcomas and high-grade carcinomas have been extremely rarely reported. Because of the rarity of disease, its treatment policy, follow-up strategy and prognosis are yet to be established and it is managed as an ovarian malignancy. We had experienced a case of clear cell adenocarcinoma arising from broad ligament and report this case with a brief review of literature.
Adenocarcinoma, Clear Cell ; Broad Ligament ; Cystadenoma, Papillary ; Female ; Follow-Up Studies ; Leiomyoma ; Prognosis ; Sarcoma

Peritoneal desmoplastic small round cell tumor is a very rare and highly aggressive neoplasm that predominantly strikes male children and young adults. It frequently presents as a large abdominal mass with widespread peritoneal involvement at diagnosis. We report one case of desmoplastic small round cell tumors in the pelvis in a old aged woman with a brief review of literature.
Aged ; Child ; Desmoplastic Small Round Cell Tumor ; Female ; Humans ; Male ; Pelvis ; Strikes, Employee ; Young Adult

Fetal chylothorax is a rare congenital manifestation that shows variable clinical outcome ranging from complete spontaneous resolution to progression into hydrops or lung hypoplasia. There is no consensus in the literature as to the optimal antenatal management despite several complications such as preterm delivery, pulmonary hypoplasia, and perinatal death. Pleuroamniotic shunting has been the treatment of choice in fetal chylothorax. Recently, new fetal therapy such as OK-432 (Picibanil) pleurodesis is being introduced. Herein, we present two cases of women referred at early 2nd trimester because of fetal hydrothorax by routine ultrasonography. Cytology obtained by thoracocentesis revealed abundant lymphocytes, suggesting chylothorax. Effusion was aspirated and OK-432 (Picibanil) was injected into the pleural space of fetus. On follow up ultrasonography, the pleural effusion was nearly resolved by adhesion of the intrathoracic space and resulted in the delivery of a healthy neonate. Intrapleural OK-432 injection may be feasible therapeutic option for selected cases in early 2nd trimester with persistent chylothorax for effective control of pleural effusion with no adverse effects.
Chylothorax ; Consensus ; Edema ; Female ; Fetal Therapies ; Fetus ; Follow-Up Studies ; Humans ; Hydrothorax ; Infant, Newborn ; Lung ; Lymphocytes ; Picibanil ; Pleural Effusion ; Pleurodesis

OBJECTIVE: The purpose of this study is to identify the cooperation between histologic diagnosis and sonographic pattern of functional ovarian cyst. And also determine performances of ultrasound, computed tomography, and tumor markers in diagnosis of functional ovarian cyst. METHODS: We retrospectively reviewed the medical records of 129 patients with ovarian cystic tumors undergone an adnexectomy between 2006 and 2008 at Kyung Hee medical center. All patients performed sonographic examinations, and a computed tomography or CA-125 or CA-19-9 were done if needed. RESULTS: Among 129 patients, 35 patients were diagnosed to be functional ovarian cyst. Sensitivity and specificity of ultrasound for functional cyst was 37.1% and 82.9%, respectively. Sensitivity and specificity of computed tomography was 47.6% and 69.3%, respectively. Tumor markers were not useful to detect functional ovarian cyst. If any one of the two appeared functional ovarian cyst, the sensitivity and specificity was 66.6%, 67.7% each. CONCLUSION: Computed tomography can be used as an alternative option replacing ultrasound, but combination of computed tomography and ultrasound does not provide the additional benefit in early diagnosis of functional ovarian cyst.
Early Diagnosis ; Female ; Humans ; Medical Records ; Ovarian Cysts ; Retrospective Studies ; Sensitivity and Specificity ; Biomarkers, Tumor

OBJECTIVE: During the last several years, such as Photofrin(R), Photogem(R), HpD, and 5-aminolevulenic acid (ALA) has been used as photosensitizers for a wide range of malignant tumors as well as non-malignant disease. A new photosensitizer, 9-Hydroxypheophorbide-a (9-HpbD-a) was derived from Spirulina platensis. The aim of this study was to evaluate the anticancer effect and mechanism of photodynamic therapy in vivo using 9-HpbD-a and 670 nm diode laser on a HT-3 cervical cancer cell line. METHODS: PDT effects were observed in xenograft nude mouse model. HT-3 cell line was xenografted into the subcutaneous space of the mouse back. When the tumors grew up to 400~500 mm3, the animals were randomly separated into 4 groups: Group I (n=5), control group; group II (n=10), 9-HpbD-a alone; group III (n=10), laser irradiation alone; and group IV (n=20), PDT in nude mouse group. RESULTS: PDT treated group (9-HpbD-a+laser irradiation) showed complete response (15/20, 75%), recurrence (3/20, 15%) or no response (2/20, 10%). PDT group showed significant remission rate, comparing to laser irradiation alone group, 9-HpbD-a alone group and untreated control group (P<0.05). When PDT using 9-HpbD-a, tumor size was decrease and microscopically finding, antitumor effect was showed inflammation and necrosis of tumor cell. Overexpression of p53 and Ki-67 gene had been detected at the HT-3 cervical cancer cell and 10 days after PDT. And no experssion in normal tissue and tumor after PDT. So, immunohistochemical study of p53 and Ki-67 gene correlated with PDT for anticancer effect. CONCLUSION: These results suggest that 9-HpbD-a is one of the promising photosensitizers for the future and would be needed to use 9-HpbD-a as a photosensitizer in clinical setting. We would further suggest that photodynamic therapy is a more effective method than the conventional treatment for women who want to maintain their anatomical and functional uterine cervix.
Animals ; Cell Line ; Cervix Uteri ; Female ; Humans ; Inflammation ; Lasers, Semiconductor ; Mice ; Mice, Nude ; Necrosis ; Photochemotherapy ; Photosensitizing Agents ; Recurrence ; Spirulina ; Transplantation, Heterologous ; Triazenes ; Uterine Cervical Neoplasms

OBJECTIVE: The aim of this study is to find out the genes which are related to ovarian cancer cell growth using large circular antisense library. METHODS: Clones for antisense library were uni-directionally sub-cloned into pBS SK (-) vector. LC-antisense molecules were then purified from the culture supernatants of the bacterial competent cells superinfected with M13K07 helper bacteriophages. The LC-antisense library to 240 unigene clone was constructed and utilized in the identification of genes functionally involved in the growth of ovarian cancer cells. RESULTS: The 17 numbers out of the 240 numbers of the antisense library exerted a marked inhibitory effect on the growth of SK-OV 3. CONCLUSION: The putative functional categorization of each gene was then conducted via public databases. These candidates may be used as target genes for drug development or adjuvant of conventional chemotherapeutic drugs.
Bacteriophages ; Clone Cells ; Estrone ; Gene Targeting ; Genetic Therapy ; Ovarian Neoplasms

OBJECTIVE: We performed this study to evaluate maternal and fetal outcomes of pregnancies with IgA nephropathy. METHODS: We reviewed 20 pregnancies occurred in 14 women who were diagnosed as IgA nephropathy with the method of renal biopsy between 1997 and 2006. We used clinical and laboratory data from medical records and statistic analysis using SPSS 15.0. RESULTS: Of 20 prenancies, there were 17 live births and 3 spontaneous abortions. There was no stillbirth and congenital anomaly. We found severe preeclampsia in 47%, low birth weight in 53% and preterm birth (comprising medical indications) in 59%. But most were late preterm birth and all were alive. Blood pressure was elevated after delivery compared with pre-pregnancy. CONCLUSION: Although pregnancy is not contraindicated in IgA nephropathy, it is associated with significant complications comprising preeclampsia, preterm birth and low birth weight.
Abortion, Spontaneous ; Biopsy ; Blood Pressure ; Female ; Glomerulonephritis, IGA ; Humans ; Immunoglobulin A ; Infant, Low Birth Weight ; Infant, Newborn ; Live Birth ; Medical Records ; Pre-Eclampsia ; Pregnancy ; Pregnancy Outcome ; Premature Birth ; Stillbirth

OBJECTIVE: To investigate and compare the amount of the lipid peroxidation and the protein carbonyls formation in maternal venous plasma of preterm premature rupture of membranes (PPROM) during antibiotics administration. METHODS: PPROM were selected between 25 and 32 weeks of gestation. Eighteen patients (group 1) were treated with amoxicillin and erythromycin for 7 day period, 18 patients (group 2) were treated with 3rd generation cephalosporin (cefodizime, cefditoren) and erythromycin for the same period. Maternal blood were obtained from the two groups before and after the antibiotics administration, day 3 and day 7. Lipid peroxidation levels and protein carbonyl contents were measured by thiobarbituric acid reaction and 2,4-dinitrophenyl hydrazine method. Other 18 women with normal pregnancy between 25 and 32 weeks of gestation of venous blood were checked same things in vitro. Interleukin (IL) -6 was measured by enzyme-linked immunosorbent assay. RESULTS: 1. The lipid peroxidation levels and protein carbonyls formation in the maternal venous plasma of PPROM was significantly higher than that of normal pregnancy (lipid peroxidation levels; 4.77+/-.36 vs 7.11+/-.41 nmol/mg protein, P<001, protein carbonyls formation; 3.55+/-.22 vs 5.69+/-.30 nmol/mg protein, P<001). 2. There were no significant differences in the lipid peroxidation levels and protein carbonyls formation of the maternal venous plasma with PPROM mixed and incubated by amoxicillin, cefodizime, cefditoren, and erythromycin (in vitro). 3. There were no significant differences in the lipid peroxidation levels and protein carbonyls formation of the venous plasma of group 1 between before and after antibiotics administration, day 3 and day 7. 4. There were no significant differences in the lipid peroxide levels of the venous plasma of group 2 between before and after antibiotics administration, day 3 and day 7. 5. The protein carbonyls formation in the venous plasma of group 2 was significantly decreased at day 3 and day 7 after antibiotics administration than that of before (6.04+/-.44 and 5.53+/-.37 vs. 7.04+/-.51 nmol/mg protein, P<005). 6. The levels of IL-6 in the venous plasma of group 2 was significantly decreased at day 7 after antibiotics administration than that of before (7.50+/-.35 vs. 3.13+/-.37 pg/mL, P<005). CONCLUSION: In the maternal venous plasma of PPROM, the lipid peroxidation levels and protein carbonyls formation were increased. The formation of protein carbonyls and IL-6 in the maternal blood of PPROM was decreased by combined treatment of 3rd generation cephalosporin and erythromycin. The results suggest that reactive oxygen species formation by inflammatory reaction is suppressed by the 3rd generation cephalosporins and erythromycin combined treatment.
Amoxicillin ; Anti-Bacterial Agents ; Cefotaxime ; Cephalosporins ; Enzyme-Linked Immunosorbent Assay ; Erythromycin ; Female ; Humans ; Hydrazines ; Interleukin-6 ; Interleukins ; Lipid Peroxidation ; Membranes ; Plasma ; Pregnancy ; Reactive Oxygen Species ; Rupture ; Thiobarbiturates

OBJECTIVE: To determine which compartments of placenta in the term pregnancy express the embryonic stem cell markers. METHODS: We have used immunohistochemical methods with antibodies to embryonic stem cell surface antigens, TRA 1-60 (Tumor rejection antigen 1-60), TRA 1-81 (Tumor rejection antigen 1-81), SSEA-3 (stage-specific embryonic antigen-3) and SSEA-4 (stage-specific embryonic antigen-4), to identify and localize stem cells in the term placenta. RESULTS: Stem cell marker-positive cells were found in all layer of placenta. Amnionic epithelial cells was immunoreactive with TRA 1-60, TRA 1-81. Amnionic mesenchymal stromal cells was immunoreactive with TRA 1-81. Chorionic mesenchymal stromal cells was immunoreactive with TRA 1-60 and TRA 1-81. SSEA-3 and SSEA-4 were not stained at any compartment of the term placenta. Compartment that was stained most strongly by TRA 1-60 was the amnionic epithelial cells layer. Compartment that was stained most strongly by TRA 1-81 was the chorionic mesenchymal stromal cells layer. CONCLUSION: The mesenchymal stroma cells of the amnion and chorion as well as amnionic epithelial cells may be useful source of pluripotent stem cells in the term placenta.
Amnion ; Antibodies ; Antigens, Surface ; Antigens, Tumor-Associated, Carbohydrate ; Chorion ; Embryonic Stem Cells ; Epithelial Cells ; Humans ; Mesenchymal Stromal Cells ; Placenta ; Pluripotent Stem Cells ; Pregnancy ; Rejection (Psychology) ; Stage-Specific Embryonic Antigens ; Stem Cells