The authors observed and treated a case of Ritter's disease, 1 month old male child, and admitted with complaint of generalized exfoliation followed by spontaneous erythema and blister on face, trunk and intertriginous areas for 3 days. The patient was treated with antibiotics and steroid-antibiotic ointment, and was discharged on 10th day after admission with cleared up of lesions.
Anti-Bacterial Agents ; Blister ; Child ; Erythema ; Humans ; Infant, Newborn ; Male ; Staphylococcal Scalded Skin Syndrome*

Disseminated superficial actinic porokeratosis (DSAP) is one of the recently found skin disorderes, which was differentiated from classicaI porokeratosis (Mibelli) and senile keratosis etc. in view of clinical features and hietogenesis by Marvin E. Chernosky on 1967. The one was 60 years old female patient, who had been suffered from multiple dark-brownish keratotic uniform minute papules on dorsa of the hands, forearms and neck with accompanying itching sensation since about 20 year's old of her age. The another one was 38years old housewffe, wha had been suffered from same lesions of the former on the face, neck, extremities especially sun-light exposed area. In both cases, skin lesions were exacerbated during each summer season and increase in numbers of the skin lesions with more severe itching sensation. Chernosky postulated none of a dark-sklnned race affording natural protection against sun-light had skin lesion of D S A P, we were abIe to find out two cases of typical D S A P ih the Korea.
Continental Population Groups ; Extremities ; Female ; Forearm ; Hand ; Humans ; Keratosis ; Korea ; Middle Aged ; Neck ; Porokeratosis* ; Pruritus ; Seasons ; Sensation ; Skin

1. Napotol solution was topically applied on a trial basis for the treatment of superficial fungal infections and 56% of patients had an excellent benefit and 14% of patients had an irritant dermatitis during the treatment. 2. The main compoeition of Napotol solution is drived from ethsnolie extraction of a natural plant and it's pharmacological action to fungal infection is not known,, yet it's antifungal action is potent as compared to other antifungal topical medicines, Napotol solution also including salicylic acid and benzoic acid, which are well known as possessing a potent antifungal property, may be accelerating it's function for the treatment of superficial fungal infection.
Arthrodermataceae* ; Benzoic Acid ; Dermatitis, Irritant ; Humans ; Plants ; Salicylic Acid

The study was made in order to investigate the minimal inhibit concentration (M.I.C) to Trichophyton(T.) gypseum and Trichophyton rubrum by same salt solution(ie: NaCl, KCl and Sodium thiosulfate). The stanis were obtained at the out-patient clinic of Seoul National University hospital. The results are as follows: 1. The M.I.C. of NaCl manifest 10%, and Trichophyton rubrum shows more higher than that of T. gypseum. 2. The M.I.C. of Sodiurn thiosulfate manifest 10%, and T. gypseum shows more higher M.I.C. than that of T. rubrum. 3. The M.I.C. of KCI manifest 15% for T.rubrum and shows 20% for T. gypseum.
Arthrodermataceae* ; Humans ; Outpatients ; Seoul ; Sodium ; Trichophyton

As an attempt to evaluate any possible effects of dimethylsulfoxide (DMSO) on the phenomena of membrane transport, effects on the short-circuit current (SCC) and potential difference (PD) across the isolated frog skin were studied under the conditions of various bathing medium, Changes of SCC and PD were measured by the method described by Ussing and Zerahn. Addition of DMSO to the inside bathing medium resulted in an initial increase in SCC followed by a secondary decline to pre-DMSO level, while DMSO at outside medium was without effect. Dose-responses(SCC) relationship revealed a linear one from 30 to 60 mM. Substitution of chloride by sulfate ion from bathing medium caused no alteration in the basic pattern and magnitude of response, thus indicating the specificity of DMSO action on the Na transport. Hypertonic solutions of DMSO added to either outer or inner bathing medium evoked a prompt fall in SCC and PD consistently. By isotopic measurement of sodium fluxes with Na24, it was evident that increased sodium influx was entirely responsible for the initial increase in SCC induced by DMSO. Of various parameters concerned with transepithelial Na transport, outer membrane permeability to Na (PoNa) was shown to be the onIy parameter which was significantly elevated by DMSO administration. From these findings, it was postulated that DMSO-induced increment in sodium influx was mediated by its stimulating action on the sodium penctration through the outer permeability barricr after binding to a receptor site different from that for the antidiuretic hormone (ADH.)
Baths ; Dimethyl Sulfoxide* ; Hypertonic Solutions ; Membranes ; Permeability ; Sensitivity and Specificity ; Skin* ; Sodium*

The 10 cases of psoriasis were treated with topical application of 0.3% of Vitamin A acid ointment, once daily, without dressing, and were observed at weekly intervals. Histopathological studies were obtained 5 cases out of former 10 psoriasis patients, before and 3 weeks after treatment. Clinical results(table 1)revealed 6 cases of good result, 4 cases of moderate resuIt in efficacy. In generally, the scales and infiltration were more rapidly responded to the treatment than the erythemas. Histopathological findings after treatment (table 2) were revealed, compare with before treatment, reduced or absence of parakeratosis, regenration of granular cell layer, reduced acanthosis, and decreased inflammatory cell infiltration in the upper derms. Side reaetions, as irritation dermatitis, occurred only on the normaI skin especially periollicular regions, which was cured easily by wet dressing with Burow's solution for a few days. Recurrences were occurred in 3 cases of the treated 10 patients, within 10 days after stop of the therapy.
Bandages ; Dermatitis ; Erythema ; Humans ; Parakeratosis ; Psoriasis* ; Recurrence ; Skin ; Tretinoin* ; Vitamin A* ; Vitamins* ; Weights and Measures

Extramammary Paget's disease is a dermatosis which pathologically and clinically resembles Paget's disease of the breast. The disease occurs in regions with apocrine gIands; most often in the anogenital area, seldom in the axilla. umbilicus, mucous membrane of the mouth, nose, ear and Moll's gland of tne eyelid. In this work the effect of bleomycin for extramammary Paget's disease was studied on ultrastructural aspect. The material was a case of extramammary Paget's disease of 7 years standing occuring in the scrotum and the pubic area by serial sections after IV injection of 60mg, 120mg and 240mg of bleomycin, and examined under the electron microscope. The results obtained are summarized as follows: 1. The size of Paget's cell and its nucleus was gradually decreased. 2. The numbers of lysosome, dense body, autophagic vacuolization and tonofilament was decreased. From these fidings, it is suggested that bleomycin induces retrograde degenerative change of Pagct's cell, and cell necrosis finally.
Axilla ; Bleomycin* ; Ear ; Eyelids ; Intermediate Filaments ; Lysosomes ; Mouth ; Mucous Membrane ; Necrosis ; Nose ; Paget Disease, Extramammary ; Paget's Disease, Mammary ; Scrotum ; Skin Diseases ; Umbilicus

The sera of 86 patients with untreated secondary syphilis were anaIyzed by immunoelectrophoresis with the specific antisyphilitic rabbit serum. Twenty-seven out of the 86 sera (31. 4%) showed more prominent IgA precipitate arcs as compared to the precipitate arcs of the normal serum. Fourteen out of the 86 scra (16. 3%) showed more promincnt IgM precipitate arcs as compared to the normal. However there was no speciific abnormal precipitate line for the syphilis serum, Quantitative analyscs of the 86 sera from the syphilitics by the Lim's modification of the Oudin capillary tube method showed that the mean of the IgG level is 2.415+53.2mg/100ml, IgA 293+8.3mg/100mI and Igm 102+3.6mg/100ml. This result represents a statistically significant increases of immune globulin levels in the syphilitics as compared with the normal controls (p<0.05).
Capillaries ; Humans ; Immunoelectrophoresis ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulins* ; Syphilis*

It has been well known for a long time that Rhus species are belonged botanically to same family called family Anacardacea and their allergenic components are identical because it contains 3-pentadecyl catechol. However, Mason (1954) and some investigators suggest the possibility that some individuals may be sensitive to a component of the oleoresin other than 3-pentadecyl catechol. By this suggestion, author performed the patch test on 138 individuals with 4 species of Korean Rhus tree (Rhus verniciflua, Rhus trichocarpa, Rhus javanica, and Rhus sylvestris.) and observed the incidence of latent sensitivity to dry leaves of Rhus trees and urushiol, The patch test results on sensitivity to Rhus verniciflua, Rhus trichocarpa, Rhus javanica, and Rhus sylvestris showed 35.50%, 27.53%, 21.01%. 28. 26%, and 29. 71% respectively and these results could make the suggestion that cross sensitivity between each Rhus trees are few and a certain specific antigenic component may be contained in every Rhus tree leaves. On animal experiment concerning the basic study for the extraction of Rhus tree antigen, author could easily sensitize the guinea pig with urushiol but couldn't challenge these animal with methanol aceton extract of Rhus leaves. From these findings, author proposed that Korean Rhus trees are different immunologically to poison ivy tree antigen and a certain specificities of antigeniciy contain in each Korean Rhus. But this postulation will need further experimental study as multiple step fractionation with Rhus tree.
Animal Experimentation ; Animals ; Guinea Pigs ; Humans ; Incidence ; Methanol ; Patch Tests ; Research Personnel ; Rhus* ; Toxicodendron ; Trees*

The authors investigated serial changes of bacillary and granularity indices from 49 previously non-treated lepromatous leprosy patients under DDS therapy during 24 month period, and the following results were obtained. 1) Pretreatment bacillary index was highest on eye brows, and chins, ear lobes, arms, legs, backs in decreasing order. The proportion of fall of B.I. during therapy showed similar tendencies in each site of smears, the average decrease being 1. 2 in the first year and 0. 8 in the second year. 2) The average granularity index before therapy was 2. 5, the rise of G.I. was rapid during first 12 months, slower during next 6 months, and no significant changes were seen during last 6 months. 3) The changes of G.I. were faster and more sensitive to therapy than that of B.I. Therefore, it. seems more valuable assesing the response of therapy, drug resistance, prognosis, etc 4) 300 mg of DDS per week appears to be sufficient for maintaining the therapeutic dosage.
Arm ; Chin ; Drug Therapy ; Ear ; Equidae ; Humans ; Leg ; Leprosy, Lepromatous ; Mycobacterium* ; Prognosis