Multipotent neural stem cells (NSCs) are operationally defined by their ability to self-renew, to differentiate into cells of all glial and neuronal lineages throughout the neuraxis, and to populate developing or degenerating CNS regions. Thus their use as a graft material can be considered analogous to hematopoietic stem cell-mediated reconstitution and gene transfer. The recognition that NSCs propagated in culture could be reimplanted into mammalian brain, where they might integrate appropriately throughout the mammalian CNS and stably express foreign genes, has unveiled a new role for neural transplantation and gene therapy and a possible strategy for addressing the CNS manifestations of diseases that heretofore has been refractory to intervention. We have tracked the response of host and transplanted NSCs to brain or spinal cord injury and explored the therapeutic potential of NSCs injected into the animal CNS subjected to focal hypoxic-ische-mic (HI) brain or spinal cord injury. Such cells integrated appropriately into the degenerating CNS, showed robust engraftment and foreign gene expression within the region of CNS injury, and appeared to have migrated preferentially to the site of injury, experienced limited proliferation, and differentiated into neural cells lost to injury, trying to repopulate the damaged CNS area. The transplantation of exogenous NSCs may, in fact, augment a natural self-repair process in which the damaged CNS "attempts" to mobilize its own pool of stem cells. Providing additional NSCs and trophic factors may optimize this response. Therefore, NSCs may provide a novel approach to reconstituting CNS damaged by HI brain or spinal cord injury. Preliminary data in animal models of hypoxic-ischemic brain injury or contusive spinal cord injury lend support to these hypotheses.
Animals ; Brain ; Brain Injuries ; Gene Expression ; Genetic Therapy ; Models, Animal ; Neural Stem Cells* ; Neurons ; Spinal Cord Injuries ; Stem Cells ; Transplants

No abstract available.
Vietnam*

The twelve patients, whose ages ranged from 18 years to 87 years, 5 of males and 7 of females, were admitted to Department of Orthopaedic Surgery of Korea University Hospital from January, 1978 to November, 1979 for total hip replacement surgery: 5 cases of the post traumatic femur neck fracture, 2 case of idiopathic aseptic necrosis, 2 cases of post infectious bony ankylosis of the hip, 1 case of sequele of Legg-Perthes disease, 1 case of secondary osteoarthritis secondary due to congenital acetabular dysplasia and acetabular dysplasia secondary to old infection. For these cases, the authors carrid out the surgery of total hip replacement through the new method of anterolateral “S” approach,combined with innominate osteotomy and autogenous bone graft of resected femoral head. Regular type of eleven Muller prosthesis and one Charnley prosthesis were adequately inserted in the enlarged acetabular socket. The results obtained are as follows: 1. This approach had the following advantages; such as the sufficient exposure of the operative field without the greater trochanteric osteotomy, the shortened operative time, the decreased amount of blood loss and the easy widening of the acetabular socket during the surgery. 2. There was no difficulty to perform simultaneously innominate osteotomy with autogenous bone graft of resected femoral head to the ilium during the same operative period. 3. The release of the rectus femoris from the anteroinferior iliac spine does not cause any weakness of the knee extension. 4. In all 12 patients, the end results of the function after this new method revealed saticefactory.
Acetabulum ; Ankylosis ; Arthroplasty, Replacement, Hip ; Female ; Femoral Neck Fractures ; Femur ; Head ; Hip ; Humans ; Ilium ; Knee ; Korea ; Legg-Calve-Perthes Disease ; Male ; Methods ; Necrosis ; Operative Time ; Osteoarthritis ; Osteotomy ; Prostheses and Implants ; Quadriceps Muscle ; Spine ; Transplants

No abstract available.
Tooth Eruption* ; Tooth* ; Transplants*

No abstract available.
Tooth Eruption* ; Tooth* ; Transplants*

Epidermolysis bullosa Dystrophica is rare, chronic non-mflammatory mechanobullous disease of hereditary trait, which easily produces bulIa by minor trauma or spontaneousIy. The lesions usually appears from birth or in infant involving especially lower leg, hand, foot and lea,ds to erosive, hemorrhagic bulla, secondary infection, pruritus and scar formation and sometimes deformity of nails and cicatrical alopecia. It sometimes involves oral mucosa, esophagus, eye, tooth, bone, respiratory system, anus and vagina. This disease has rare tendency for carcinogenesis from cicatrical Iesions. These manifestations are more severe in recessive type than in dominant type. We had observed 5 cases of EBD at Ewha Womans University Hospital from Sept. 1975. to Jul. 1976. Among 5 cases, 4 cases occurred from birth, 1 case occurred at age l. Skin lesivns were hand, foot, knee area in all 5 cases. Head, face were involved in 2 cases. Arm, leg, trunk, buttock were involved in 3 cases. In skin manifestations, bulla, erosive bulla, secondary infection, scar formation, pruritus, nail deformity, positive Nikolsky sign were observed in all 5 cases. Hemorrhagic bulla, miliaria. were presented, in 1 case, alopecia in 2 cases. Aggrevated season were summer in 4 cases, spring in 1 case, HistologicalIy, microscopic observation, after H@-E stain, revealed hyperkeratosis in 3 cases, acanthosis in 2 cases, partial atrophy in 1 case, partial ulcer in 1 case, snbepidermal bulla in 5 cases, chronic nonspecific inflamma- tory cell infiltration of upper dermis in 3 cases, fibrosis of lower dermis in 1 case.
Alopecia ; Anal Canal ; Arm ; Atrophy ; Buttocks ; Carcinogenesis ; Cicatrix ; Coinfection ; Congenital Abnormalities ; Dermis ; Epidermolysis Bullosa Dystrophica* ; Epidermolysis Bullosa* ; Esophagus ; Female ; Fibrosis ; Foot ; Hand ; Head ; Humans ; Infant ; Knee ; Leg ; Miliaria ; Mouth Mucosa ; Parturition ; Pruritus ; Respiratory System ; Seasons ; Skin ; Skin Manifestations ; Tooth ; Ulcer ; Vagina

No abstract available.
Humans ; Incontinentia Pigmenti* ; Male*

During 10 years (from 1986 to 1995), 54 patients were diagnosed as maxillary cancer and undergone maxillectomy in department of Oral and Maxillofacial Surgery, Korea Cancer Center Hospital. We studied clinically about their age and sex distribution, TNM staging, histopathologic diagnoses, treatment modalities, overall survival rates, survival rates according to stages and treatment modalities. In them, 23 patients were delivered maxillary obturators, we also studied clinically about them and their obturators. The overall 3-year and 5-year survival rates of these maxillectomized patients were 59.0% and 55.0%. The 5-year survival rates of stage II and stage III patients was 63.0%, and that of stage IV patient was 50.0%. According to treatment modalities, The 5-year survival rates in cases of surgery only was 66.7%, in cases of preoperative chemotherapy and/or radiaiotherapy was 63.5%, in cases of postoperative radiotherapy and/or chemotherapy was 50.4%. The 5-year survival rate of obturator delivered patients was 56.8%, and that of no-obturator delivered patients was 51.8%. The using rates of obturator were 70.5% at 1 year, 59.7% at 2 years, and 53.0% at 3 years.
Diagnosis ; Drug Therapy ; Humans ; Korea ; Neoplasm Staging ; Radiotherapy ; Sex Distribution ; Surgery, Oral ; Survival Rate

It is well known that total colonoscopy is one of the essential procedure to make diagnosis of colonic and terminal ileal diseases, to detect early atage of colonic cancer and to do prophylactic removal of premalignant polyp. Previously commonly used longer colonoscope has been reached to ileocecal area with patients much discomfort arising from excessive loop formation at sigmoid or transverse colon because of no limitation of the length. (continue...)
Colon ; Colon, Sigmoid ; Colon, Transverse ; Colonic Neoplasms ; Colonoscopes ; Colonoscopy ; Diagnosis ; Humans ; Ileal Diseases ; Polyps

Demodicidosis is caused by the enormous infestation of 400 micron sized demodex folliculorum which normally exist, though in small number, in pilosebaceous unit. Its characteristic clinical feature is erythema and erythematous indurated papulopustular eruptions combined with itching and buming sensation. Microscopic examination of indurated pustule always reveals demodex folliculorum. Many authors have reported that demodicidosis aggravated by avoidance of using soap, long-term use of cosmetic cream, especially cold cream, topical or systemic use of corticosteroid. Our patiednts were housewives of 46,39, and 42 years old and presented characteristic clinical featurss and skin lesions by topical application of corsicosteroid for 1~2 years and were diagnosed as steroid acne. But simple microscopic examination reveled demodex folliculorum. We treated them with 5% sulfur lintment and soap and water cleansing of face with remarkable clinical improvement.
Acne Vulgaris ; Adult ; Erythema ; Humans ; Pruritus ; Sensation ; Skin ; Soaps ; Sulfur ; Water