1.Dejerine-Sottas Disease: One Case Report
Myung Chul YOO ; In Hoi KOO ; Chong Kwan KIM
The Journal of the Korean Orthopaedic Association 1983;18(2):415-418
A case of hypertrophic interstitial neuropathy in a 32 years old man developed in the median nerve is reported. This is a rare disease characterized by thickened peripheral nerves which may be palpable and visible. This case was treated by excision of transverse carpal ligament and external and internal neurolysis.
Hereditary Sensory and Motor Neuropathy
;
Ligaments
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Median Nerve
;
Peripheral Nerves
;
Rare Diseases
2.The Role of Nitric Oxide in Seizures Induced by Pentylenetetrazole.
Journal of the Korean Pediatric Society 2000;43(10):1356-1363
PURPOSE: Nitric oxide(NO) is a highly reactive messenger molecule that is synthesized by nitric oxide synthase(NOS) in a number of tissues including the brain. Our aim was to examine the possible role of NO on pentylenetetrazole(PTZ)-induced seizure in rats as a proconvulsant or an anticonvulsant. METHODS: Male Sprague-Dawley rats weighing 200-300g were used. PTZ(40mg/kg) was used to induce seizure. In order to examine the role of NO in seizures, the neuronal nitric oxide synthase (nNOS) was blocked by a specific inhibitor, 50mg/kg 7-nitroindazole(7-NI), and a non-specific inhibitor, 50mg/kg L-nitroarginine(L-NA). Both 7-NI and L-NA were administered 30 min before the administration of PTZ. We evaluated the onset time of the first myoclonic jerk and the nature of seizures, such as the types and severity of the seizures in each group. Western blot and RT-PCR were used to examine the expression of nNOS mRNA and proteins in the hippocampus of each group. RESULTS: The onset time of the first rnyoclonic jerk was markedly delayed in the 7-NI and L-NA pretreated groups in comparison to the PTZ group. In addition, 7-NI and L-NA markedly sup- pressed the severity of PTZ-induced seizure. The expression of nNOS mRNA was higher in the PTZ and 7-NI pretreated groups than in the control group. The expression of nNOS protein was more suppressed in the 7-NI and L-NA pretreated groups than in the PTZ group. CONCLUSION: The expression of nNOS protein appears to increase in PTZ-induced seizures. Both specific and non-specific NOS inhibitors produce a reduction in seizure activity and nNOS protein expression. These results suggest that nNOS may be in a close relationship with seizures, and NO may play an important role as a proconvulsant in the PTZ-induced seizure in rats.
Animals
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Blotting, Western
;
Brain
;
Hippocampus
;
Humans
;
Male
;
Myoclonus
;
Nitric Oxide Synthase Type I
;
Nitric Oxide*
;
Pentylenetetrazole*
;
Rats
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Rats, Sprague-Dawley
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RNA, Messenger
;
Seizures*
3.A Case of Atrial Septal Defect in Identical Twins.
Jong Tae LEE ; Hun Kwan LIM ; Tae Myeung CHOI ; Sung Koo KIM ; Young Joo KWON
Korean Circulation Journal 1994;24(5):722-725
Atrial septal defect is one of the most common congenital heart diseases in adult, of which absolute causes is not confirmed, but explained by multifactorial inheritance. In Korea, there has been no case report of atrial septal defect in identical twins in spite of some reports of atrial septal defect in relatives and twins in other countries. We present a first case of atrial septal defect in identical twins whose mother had no infection or medication history during pregnancy.
Adult
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Heart Diseases
;
Heart Septal Defects, Atrial*
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Humans
;
Korea
;
Mothers
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Multifactorial Inheritance
;
Pregnancy
;
Twins
;
Twins, Monozygotic*
4.Manidipine Monotherapy in Patients with Mild to Moderate Essential Hypertension.
Jong Koo LEE ; Seong Wook PARK ; Jae Kwan SONG ; Jae Joong KIM ; Seung Jung PARK
Korean Circulation Journal 1992;22(2):301-306
A clinical trial was done to evaluate the antihypertensive efficacy and side effects of manidipine, a new calcium antagonist, in 30 patients with mild to moderate essential hypertension. 1) The study patients consisted of 19 men and 11 women, and the mean age was 51.8 years. 2) Blood pressure dropped significantly in 2 weeks and in 4 weeks, and well maintained throughout the study period. The mean-pressure drop was 26.2/14.9mmHg after 10 weeks. 3) Heart rate did not change significantly with manidipine therpy. 4) Optimal dose for effective pressure-drop was between 10 and 20 mg in 86% of patients. Overall good antihypertensive effect was achieved in 83% of patients. 5) All of the laboratory parameters including blood chemistry, glucose, lipid and electrolytes did not change, but serum calcium increased from 9.2% mg/dl (p=0.001) in 10 weeks. 6) Side effects were mild in nature(palpitation in 3, dry mouth in 1, weakness in 1 and impotence in 1 patient). In conclusion, manidipine monotherapy with 10 to 20 mg once a day regimen is effective and well tolerated in the patients with mild to moderate essential hypertension.
Blood Pressure
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Calcium
;
Chemistry
;
Electrolytes
;
Erectile Dysfunction
;
Female
;
Glucose
;
Heart Rate
;
Humans
;
Hypertension*
;
Male
;
Mouth
5.A Case of Subdural Tension Pneumocephalus after Operation.
Seong Ho KIM ; Whan Whae KOO ; Kwan Tae KIM ; Youn KIM
Journal of Korean Neurosurgical Society 1985;14(2):469-474
Tension pneumocephalus is rare complication is neurosurgical operation. But it should be treated promptly because of sudden neurological deterioration. Computed tomography permitted rapid diagnosis including localization of the air, thus facilitating prompt treatment. A case of subdural tension pneumocephalus after cranial operation under the impression of bifrontal subdural hygroma is presented.
Diagnosis
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Pneumocephalus*
;
Subdural Effusion
6.A Case of Oligodendroglioma Presenting as Ventricular Hemorrhage After Head Injury.
Whan Whae KOO ; Jin Young YOUM ; Kwan Tae KIM ; Youn KIM
Journal of Korean Neurosurgical Society 1985;14(4):749-754
Oligodendroglioma constitutes about 4% of all gliomas. The usual symptoms of oligodendrogliomas are seizures, focal neurologic deficits, and increased intracranial pressure. They usually present with a gradual onset of symptoms and slow progression. The apopletic symptom due to sudden tumor bleeding is rare. The author review literatures and present a case of oligodendroglioma initially manifested as ventricular hemorrhage after head injury.
Craniocerebral Trauma*
;
Glioma
;
Head*
;
Hemorrhage*
;
Intracranial Pressure
;
Neurologic Manifestations
;
Oligodendroglioma*
;
Seizures
7.Surgical Correction of Ruptured Aneurysm of Aortic Sinus of Valsalva.
Kwan Sik KIM ; Bum Koo CHO ; Seung Nok HONG
Yonsei Medical Journal 1979;20(2):162-169
This is a report of 13 cases of surgically corrected ruptured aneurysm of the aortic sinus of Valsaha. The simultaneous trans-venous and trans-arterial catheterization and cineangiogram are the best diagnostic procedures. In 12 cases, the aneurysm originated from the right coronary sinus and only one from the noncoronary sinus. Eleven aneurysms ruptured into the right ventricle and 2 into the right atrium. Eight cases were associated with ventricular septa1 defect and 5 with aortic regurgitation. In three cases the Hancock porcine valve replacement was done. There was no surgical mortality.
Adolescent
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Adult
;
Aortic Aneurysm/surgery*
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Aortic Rupture/diagnosis
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Aortic Rupture/surgery*
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Child
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Female
;
Heart Catheterization
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Human
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Male
;
Sinus of Valsalva/surgery*
8.Impaired Endothelium-Dependent Responsiveness in Porcine Coronary Arteries with Chronic Regenerated Endothelium.
Seung Jung PARK ; Seong Wook PARK ; Jae Joong KIM ; Jae Kwan SONG ; Jong Koo LEE ; Paul M VANHOUTTE
Korean Circulation Journal 1994;24(1):118-134
No abstract available.
Coronary Vessels*
;
Endothelium*
9.Magnesium Sulfate in the Treatment of Torsade De Pointes.
Cheol Whan LEE ; Jae Joong KIM ; Jae Kwan SONG ; Seong Wook PARK ; Seung Jung PARK ; Jong Koo LEE
Korean Circulation Journal 1994;24(4):617-623
No abstract available.
Magnesium Sulfate*
;
Magnesium*
;
Torsades de Pointes*
10.A Clinical Study on the Cardiac Toxicity of Adriamycin.
Jae Kwan SONG ; Yoon Koo KANG ; Kyung Ja CHO ; Duk Kyung KIM ; Dae Won SOHN ; Jeong Wook SEO
Korean Circulation Journal 1991;21(2):240-247
To clarify the exact role of endomyocardial biopsy in the diagnosis and monitoring of adriamycin-induced cardiotoxicity and to observe the actual relationship between pathologic changes and cardiac dysfunction, a cross-sectional clinical study was conducted. Echocardiography was used to evaluate cardiac dysfunction in 18 patients who had received chemotherapy including adriamycin(mean dose : 410mg/m2 of B.S.A.) without clinical evidence of congestive heart failure, and in 19 normal controls. Six patients receiving adriamycin underwent 7 transfemoral endomyocardial biopsy procedures, and the specimens were evaluated by light and electron microscopy for evidence of drug-related cardiotoxicity. Indexes of cardiac systolic function obtained by M-mode echocardiography(left ventricular dimension, excursion of interventricular septum and left ventricular posterior wall, shortening fraction and ejection fracton) did not show any statistically significant difference between patients who received adriamycin and normal controls. In transmitral flow-velocity curves recorded by Doppler echocardiography with a 2.25MHz probe, the patients showed less E peak velocity and decreased E/A ratio compared with normal controls, which suggests left ventricular diastolic dysfunction in the patients who received adriamycin. All the specimens of the endomyocardial biopsy showed significant pathologic changes of adriamycin indnced cardiotoxicity which was characterized by myofibrillar loss and vacuolization of the cytoplasm. In 2 specimens, pathologic grade was II, while 5 specimens showed pathologic changes of grade III and further chemotherapy with adriamycine was not done in thse 5 cases. From these results it is suggested that pathologic changes precede the clinical onset of congestive cardiomyopathy in the patients receiving adriamycin and left ventricular diastolic dysfunction occurrs before ejection fraction falls to subnormal levels. We conclude that sequential endomyocardial biopsy is absolutely indicated for exact diagnosis and monitoring of adrinamycin-induced cardiotoxicity to prevent the development of irreversible and often fatal cardiomyopathy.
Biopsy
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Cardiomyopathies
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Cardiomyopathy, Dilated
;
Cytoplasm
;
Diagnosis
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Doxorubicin*
;
Drug Therapy
;
Echocardiography
;
Echocardiography, Doppler
;
Heart Failure
;
Humans
;
Microscopy, Electron