Control programme of malayan filariasis by diethylcarbamazine was set up in village, Cheju-Island, Korea. The daily dose of 6 mg per kg of body weight for 6 days was chosen as a chemotherapeutic course only for microfilaria positives, which was repeated with an interval of one or two months. For the evaluation of drug control programme the yearly posttreatment blood survey was carried out. The results collected from 1970 to 1973 were analysed from the various points of view, such as microfilaria positive rates, incidence as well as prevalence rates. The change of microfilaria counts was also utilized for the comparison of the intensity of infection among population in the four year blood surveys. Considering the extremely skewed distribution of average microfilaria density, the mode of frequency distribution of microfilaria density in a population was particularly taken into account for the evaluation of changing endemicity affected by diethyecarbamazine treatment. The equation; Y= a+b log X(a , b: constants, X=microfilaria density; Y=probit scale of cumulative frequency of positives to X microfilariae) was found to fit farily well the data collected from four-year surveys before and after treatment. From these data obtained, four regression lines have been drawn by determining "a" and "b"; two paramenters, which were increased year by year since inauguration of control programme. In the present investigation, it was verified that the chmotherapeutic control measure of malayan filariasis applied in a village of Cheju-Island has been successfully carried out and the quantitative level of endemicity inthis area has also been distinctly lowered within the four-year control programme.
parasitology-helminth-nematoda-Brugia malayi ; chemotherapy-diethylcarbamazine ; control ; filariasis ; diethylcarbamazine

No abstract available.
Animals ; Cell Adhesion* ; Female ; Leiomyoma* ; Mice ; Myometrium* ; Neural Cell Adhesion Molecules*

The recent development of endoscopic retrograde cholangiopancreatography (ERCP) now permits the collection of pure human pancreatic secretions via duodenoscopic cannulation. Study objectives are evaluation of exocrine pancreatic function and analysis of pure pancreatic juice collected by use of ERCP technique in subjects without pancreatic disease. From March to July 1993, we performed ERCP and collection of pure pancreatic juice in 10 patients without evidence of pancreatic disease. (continue...)
Catheterization* ; Cholangiopancreatography, Endoscopic Retrograde ; Duodenoscopy ; Humans ; Pancreatic Diseases ; Pancreatic Juice*

Sebaceous hyperplasia is not a rare disorder and commonly develops on the face over the age of forty. The typical clinical manifestations are 2 ~ 3mm sized, single or multiple, soft protuberant yellowish nodules with central umbilication and histology shows a group of mature sebaceous lobules and central sebaceous ducts. We report an exceptionally "giant" size of sebaceous gland hyperplasia which lead us to such clinical impressions as an acrochordon, intradermal nevus, and verruca vulgaris. Histologically, the lesion showed a greatly enlarged sebaceous gland composed of numerous lobules grouped around a wide sebaceous duct. Besides the extraordinarily large size of the nodule, the benign proliferating pattern led us to a diagnosis of giant sebaceous hyperplasia.
Diagnosis ; Hyperplasia* ; Nevus, Intradermal ; Sebaceous Glands* ; Warts

PURPOSE: To study the availability of the radiological classification for incongruent hallux valgus deformities, which has been used as the key to the algorithm for selecting surgical options. MATERIALS AND METHODS: To determine radiological severity, 257 cases of incongruent hallux valgus deformities were studied. The hallux valgus angle (HVA) and the 1/2 intermetatarsal angle (IMA) were measured in each case. Following Mann's radiological classification system, the HVA and IMA were compared to determine any similarity in severity. The distal metatarsal articular angle (DMAA) was also measured to observe the extent of its effect on the incongruent deformity. RESULTS: The HVA was 36.1degrees on average (range, 16-60degrees) and the 1/2 IMA was 15.8degrees on average (range, 5-30degrees). In 126 cases (49.1%), the severity between the 1/2 IMA and HVA coincided with the index classification, whereas. 131 cases (50.9%) did not correspond. Overall, the severity of approximately half the cases, could not be graded. The DMAA was 15.6degrees on average (range, 0-40degrees) and 133 cases (51.8%) demonstrated a value above normal value (>15degrees). CONCLUSION: The radiological classification system used as a guide for surgical decision-making needs to be revised, due to the overt limits of correspondence between the severity of the 1/2 IMA and HVA. Because the HVA would be influenced by both the lateral subluxation and bony deformity around the first metatarsophalangeal joint, it is reasonable to consider these factors on the HVA as elements to be corrected individually, instead of the HVA alone.
Classification* ; Congenital Abnormalities* ; Hallux Valgus* ; Hallux* ; Metatarsal Bones ; Metatarsophalangeal Joint ; Reference Values

It is thought that the biological aggressiveness of meningioma is closely related to the development of peritumoral edema. However, the effects of mechanical tumor factors on the venous return of underlying brain tissue, as well as those of MIB-1 or p53 immunoreactivity on the brain edema formation are still not clear. To identify factors which may influence meningioma-associated peritumoral edema development, the authors examined 28 histologically proven intracranial meningiomas(22 benign, 4 atypical, and 2 malignant meningioma patients). Correlation between the degree of brain edema and various factors including volume of the tumor, venous sinus involvements, tumor location, histologic subtypes, MIB-1 labeling index(LI), and immunoreactivity of p53 protein was analyzed retrospectively. The degree of brain edema(edema ratio) was measured by maximum edema area to maximum tumor area as seen on T2 and T1 enhanced magnetic resonance images, respectively. Mean maximum tumor area and the volume of the tumor were 15.7cm2 and 50.2cm3, respectively. The mean area of maximum edema extension was 23.3cm2 and the mean ratio between maximum edema area and tumor area was 1.90(range: 0-11.5). Tumor volume and the area of edema showed significant correlation(p=0.015). MIB-1 LI, however, correlated inversely with edema ratio(p=0.039). p53 protein expression, venous sinus involvement, age, sex, and histologic characteristics did not correlated with edema area or ratio. In conclusion, this study showed there was inverse correlation between edema development and MIB-1 LI, and no correlation with p53 expression. It was thus speculated that peritumoral edema in meningioma may not be a sign of biological aggressiveness.
Brain ; Brain Edema ; Edema* ; Meningioma ; Retrospective Studies ; Tumor Burden