1.Surgical Treatment of the Metastatic Tumors of the Femur.
Han Koo LEE ; Sang Hoon LEE ; Han Soo KIM ; Kwang Hyun YOO
The Journal of the Korean Orthopaedic Association 1997;32(5):1224-1231
Metastasis to bone with destruction of the skeletal system is a common problem in old patients with malignancy. Destruction of the musculoskeletal system poses major problems for the patients, including uncontrollable pain, forced immmobilization, pathologic fracture and hypercalcemia. The purpose of this study is to evaluate the effectiveness of surgical treatment and to suggest treatment guidelines for impending or established pathologic fractures due to metastasis of the femur. Between 1985 and 1995, thirty six patients who had pathologic or impending fractures in the femur underwent surgical treatment. The indications of surgery for pathologic fractures are 1) the possibility of survival time more than three months, 2) more benefits of sungical treatment than those of conservative treatment, 3) the possibility of rigid internal fixation, 4) patient s general condition allowing surgery, and those in impending fractures are 1) cortical destruction more than 50% or lytic lesion more than 2.5cm. The method of surgery was excision of the tumor and rigid internal fixation to allow early ambulation with or without bone cement augmentation. The results were analyzed by three criteria, the performance status, pain relief and survival time. Pain relief more than Lots was achieved in 80.6% of patients according to the Kaiko's criteria. The performance status improved more than one grade in all patients except one who died of acute respiratory failure and the mean improvement was 1.8 grade by the Functional Classification of the New York Heart Association. Postoperatively, most of the patients had only slight to moderate limitation of physical activities and felt comfortable at rest and ordinary activities. The survival time was 20.9 months in patients with single metastasis and 10.2 months in patients with multiple metastases. But there was no statistical significance due to large deviation of survival time in each case. In summary, surgical stabilization of the pathologic lesion involving the femur provided definite improvement of quality of life including pain relief and early ambulation. In selected patients with single metastasis, low grade malignancy, or good performance status, postoperative survival time may be expected to be prolonged. More aggressive treatment for the metastatic lesion of the femur is suggested.
Classification
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Early Ambulation
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Femur*
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Fractures, Spontaneous
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Heart
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Humans
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Hypercalcemia
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Motor Activity
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Musculoskeletal System
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Neoplasm Metastasis
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Quality of Life
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Respiratory Insufficiency
2.A Case of Yellow Nail Syndrome.
Kwang Hyun CHO ; Joo Heung REE ; Yoo Shin LEE ; Sung Koo HAN
Korean Journal of Dermatology 1988;26(4):615-618
We report a 58 year old man who complained that his nails didn't grow for a year and developed yellowish discoloration. On physical examination his nails showed yellow greenish discoloration, increased corvexity, loss of lunulae and cuticles. C]iest X ray revealed atelectasis on right lower lung field and bronchiectasis on left lower lung field. Mild restrictive pattern was observed in pulmoniry function test. We gave him 800IU of Vitamin E claily for 3 months, but rio remarkable changes have been observed as yet..
Bronchiectasis
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Humans
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Lung
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Middle Aged
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Physical Examination
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Pulmonary Atelectasis
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Vitamin E
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Vitamins
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Yellow Nail Syndrome*
3.Promoter Polymorphism (rs12770170, -184C/T) of Microseminoprotein, Beta as a Risk Factor for Benign Prostatic Hyperplasia in Korean Population.
International Neurourology Journal 2014;18(2):63-67
PURPOSE: Benign prostatic hyperplasia (BPH) is the most common prostate disease in aging men. Microseminoprotein-beta (MSMB) is abundant in semen. In this study, we investigated association between single nucleotide polymorphisms (SNPs) at the promoter of the MSMB gene and the risk for developing BPH in a Korean population. METHODS: We genotyped two promoter polymorphisms (rs12770171, -184C/T and rs10993994, -2C/T) of the MSMB gene by direct sequencing. Ninety-five BPH patients and 78 control subjects were recruited for this study. SNPStats and Haploview version 4.2 were used for genetic analyses. Multiple logistic regression models (codominant, dominant, recessive, and log-additive models) were applied to determine the odds ratio (OR), 95% confidence interval (CI), and P-value. RESULTS: Genotype frequency of the rs12770171 SNP showed significant difference between BPH patients and controls (OR, 2.14; 95% CI, 1.07-4.27; P=0.032 in the codominant 1 model; OR, 2.31; 95% CI, 1.19-4.47; P=0.011 in the dominant model; and OR, 2.05; 95% CI, 1.17-3.61; P=0.009 in the log-additive model). Moreover, the SNP also showed association between the two groups (OR, 2.05; 95% CI, 1.19-3.52; P=0.009). The rs10993994 SNP was not associated with BPH. In haplotype analysis, CC and TT haplotypes were associated with BPH (P<0.05). CONCLUSIONS: This result indicates that a promoter polymorphism (rs12770170, -184C/T) in the MSMB gene may be associated with BPH development in a Korean population.
Aging
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Genotype
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Haplotypes
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Humans
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Logistic Models
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Male
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Odds Ratio
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Polymorphism, Single Nucleotide
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Prostate
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Prostatic Hyperplasia*
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Risk Factors*
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Semen
4.Pityriasis Lichenoides in Children.
Kyu Han KIM ; Koo Il SEO ; Kwang Hyun CHO ; Yoo Shin LEE
Annals of Dermatology 1992;4(2):63-67
No abstract available.
Child*
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Humans
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Pityriasis Lichenoides*
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Pityriasis*
5.The fracture of the talar neck the significances of Hawkins' sign.
In KIM ; Seung Koo RHEE ; Sung Soo KIM ; Won Yoo KIM ; Chang Whan HAN ; Hyung Gwan KIM
The Journal of the Korean Orthopaedic Association 1992;27(1):169-175
No abstract available.
Neck*
6.Clinical characteristics of diffuse panbronchiolitis.
Young Whan KIM ; Chul Gyu YOO ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1992;39(1):28-34
No abstract available.
7.The role of hydroxyl radical in the pathogenetic mechanism of endotoxin-induced acute lung injury in rats.
Young Soo SHIM ; Chul Gyu YOO ; Young Whan KIM ; Sung Koo HAN ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1992;39(2):120-130
No abstract available.
Acute Lung Injury*
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Animals
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Hydroxyl Radical*
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Rats*
8.The role of pulmonary capillary pressure in the oxygen free radical- induced acute lung injury.
Chul Gyu YOO ; Young Whan KIM ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1992;39(6):474-483
No abstract available.
Acute Lung Injury*
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Capillaries*
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Oxygen*
9.Screening for early detection of lung cancer: results from Seoul National University Hospital.
Yong Chol HAN ; Chul Gyu YOO ; Young Whan KIM ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM
Tuberculosis and Respiratory Diseases 1991;38(2):119-127
No abstract available.
Lung Neoplasms*
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Lung*
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Mass Screening*
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Seoul*
10.Experimental Animal Models of Neurogenic Bladder Dysfunction.
International Neurourology Journal 2010;14(1):1-6
Neurogenic bladder is related to various types of neurogenic disease and injury, including cerebrovascular accident, brain tumor, spinal cord injury, and Parkinson's disease. The results of urodynamic study show different types of detrusor and sphincter function. According to these urodynamic results, the physician decides on a treatment plan, such as anticholinergics or alpha-blockers. In the development of a new medication, it is necessary to test the medication's efficacy and toxicity by using a laboratory animal. The proper laboratory animal should have several characteristics. These are biological similarity to humans, a short generation period, and an environment that is easy to control. We describe the development of laboratory animals for the study of neurogenic bladder by decerebration, stroke, and spinal cord injury.
Animals, Laboratory
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Brain Neoplasms
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Cholinergic Antagonists
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Humans
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Models, Animal
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Parkinson Disease
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Spinal Cord Injuries
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Stroke
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Urinary Bladder, Neurogenic
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Urodynamics