1.Role of p75 neurotrophin receptor in neuronal apoptosis after cerebral ischemia
Linhui PENG ; Kongping LI ; Lixuan ZHAN ; Xialin ZUO ; En XU
International Journal of Cerebrovascular Diseases 2021;29(1):58-63
p75 neurotrophin receptor (p75 NTR) is a member of the tumor necrosis factor receptor superfamily, which interacts with tropomyosin receptor kinase (Trk) receptor or binds neurotrophic factors. It mediates a variety of complex signal transduction pathways, induces synaptic growth and affects cell survival. After acute cerebral ischemia, p75 NTR binds effector factors such as pro-nerve growth factor (proNGF) and sortilin, activating downstream apoptotic signal molecules and leading to neuronal death. Therefore, elucidating the pathways and molecular mechanisms of p75 NTR that mediate neuronal apoptosis in acute cerebral ischemia is of great significance for the development of new therapeutic drugs for acute cerebral ischemia.
2.Roles and mechanisms of connexin 43 in cerebral ischemia-reperfusion
Kongping LI ; Jianhua ZHENG ; Xiaohui CHEN ; Minhua FANG ; En XU
International Journal of Cerebrovascular Diseases 2018;26(9):708-716
In the central nervous system, gap junctions exist between neurons and glial cells. Among them, connexin 43 (Cx43) is one of the most abundant connexin proteins in the central nervous system,involved in the metabolic coupling of intercellular substance exchange and electrical coupling of electrical signaling. It plays an important role in regulating cell metabolism, homeostasis, and cell differentiation. After cerebral ischemia, the uncoupling of gap junctions and abnormal hemichannel activity cause a steady-state imbalance of the internal and external environment of the cells, eventually leading to brain tissue damage.Therefore, maintaining the normal function of Cx43 is essential for protecting brain tissue from neuronal damage induced by cerebral ischemia-reperfusion.
3.Role of CCAAT/enhancer binding protein β in acute cerebral ischemia
Tieshi ZHU ; Kongping LI ; Xialin ZUO ; Xiaohui CHEN ; En XU
International Journal of Cerebrovascular Diseases 2022;30(10):792-796
CCAAT/enhancer binding protein β (C/EBPβ), a transcriptional factor of the basic-leucine zipper family, can regulate the transcription activity of downstream target genes. After acute cerebral ischemia, the activity of C/EBPβ changes, and participates in the process of cerebral ischemia injury by regulating neuronal apoptosis and inflammation. This article reviews the molecular biological characteristics of C/EBPβ and its expression changes and role in acute cerebral ischemia, providing a basis for developing new neuroprotective drugs for acute cerebral ischemia using C/EBPβ as therapeutic target.