Objective:To explore the effect of nursing based on Roy adaptation model on negative emotions and adverse reactions in patients with multiple myeloma during chemotherapy.Methods:Using the convenient sampling method, a total of 100 patients with multiple myeloma who were admitted to Zhoushan Hospital in Zhejiang Province from July 2017 to August 2019 were selected. They were divided into the control group and the observation group by lottery method, with 50 cases in each group. The control group was given routine nursing measures while the observation group was given nursing based on Roy adaptation model on basis of the control group. And patients in both groups were also given the same chemotherapy intervention.The incidence of negative emotions, chemotherapy compliance, nursing satisfaction and adverse reactions after nursing were compared between the two groups.Results:There were no statistically significant differences in the scores of anxiety and depression before nursing between the two groups ( P>0.05) . The scores of anxiety and depression of the two groups after nursing were lower than those before nursing, and the scores of the observation group after nursing were lower than those of the control group, and the differences were statistically significant ( P<0.01) . The incidence of adverse reactions after nursing in the observation group (12.00%, 6/50) was lower than that of the control group (48.00%, 24/50) , and the difference was statistically significant ( P<0.01) . In the observation group, the proportions of patients with good treatment compliance and nursing satisfaction were respectively 90.00% (45/50) and 96.00% (48/50) , which were higher than 64.00% (32/50) and 80.00% (40/50) in the control group, and the differences were statistically significant ( P<0.05) . Conclusions:Nursing based on Roy adaptation model on the basis of routine nursing can improve the adverse reactions of patients with multiple myeloma during chemotherapy, relieve their negative emotions and improve their compliance and nursing satisfaction, which is worthy of promotion and application.