1.The Efficiency of Water Treatment Procedures on Removal of Cyanobacterial Toxins in Drinking Water
Fanling KONG ; Zengke ZHAO ; Li LI
Journal of Environment and Health 1993;0(03):-
To provide the human being with safe drinking water is one of the most important issues in public health. In response to the more and more serious pollution of algal toxins, growing concern has been attached to the water bodies contaminated with algal toxins and the effects posed on human health. Drinking water suppliers are confronted with the important problem of how to remove the toxins to the acceptable levels. Conventional water treatment procedures are not efficient in removing toxins. Activated carbon adsorption, membrane filtration, photocatalic process, ozonation and chlorination are effective in removing cyanobacterial toxins, but each has its limitation.
2.Discussion on differentiation laws of traditional Chinese medicine syndromes of patients with sepsis and gastrointestinal dysfunction
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2013;(3):134-137
10.3969/j.issn.1008-9691.2013.03.003
3.Construction of systematic evaluation guideline of transformation feasibility of achievements in medical research
Xiangjin KONG ; Zhenyu LI ; Yao ZHAO
Chinese Journal of Medical Science Research Management 2008;21(4):217-219
The prospective evaluation of the transformation feasibility of the research achievements is an important portion of the evaluation of the medical research achievements.This study explored to set up a system with Delphi method for the evaluation guideline of the hlansformation feasibility of the medical research achievements.And it also offered some evaluating methods and theoretical guidance to carry out the transformation feasibility of the achievements in the medical scientific research.
4.Role of tumor necrosis factor -alpha -induced protein 8 -like 2 in development and progression of liver and gastro-intestinal tumors
Li KONG ; Meng JIN ; Suxian ZHAO
Journal of Clinical Hepatology 2017;33(1):175-179
Liver and gastrointestinal tumors greatly threaten human health and have poor therapeutic outcomes and prognosis.Tumor necrosis factor -alpha -induced protein 8 -like 2 (TIPE2)can negatively regulate innate immunity and adaptive immunity and maintain immune ho-meostasis.Recent studies have found that TIPE2 can affect various signaling pathways and thus exerts an inhibitory effect on the development and progression of tumors.This article briefly introduces the structure and function of TIPE2 and its regulatory effect on tumor -related sig-naling pathways such as Ras,Ral,and Rac and downstream molecules,as well as the role of TIPE2 in liver and gastrointestinal tumors,re-lated signaling pathways,and research advances.
5.Exploring Effective Way for Improving Operating Room Nurses′Humanistic Exploring Effective Way for Improving Operating Room Nurses′Humanistic Quality by Using the Morning Shift Time Quality by Using the Morning Shift Time
Deling KONG ; Mingxu WANG ; Demin KONG ; Xiangli LI ; Shuzhen KONG ; Liyan ZHAO ; Xiaoli QUAN
Chinese Medical Ethics 2015;(5):795-798
Objective:To explore the effective way of cultivating the operating room nurses′humanistic quality by using the morning shift and to improve operating room nurses′comprehensive quality .Methods:The operating room nurses were divided into five specialist groups according to the nurses′levels, helping each group to determine the training topic of humanistic quality training , via taking a variety of training methods to promote operating room nurses′humanistic quality by making good use of the morning shift time .Results: Through taking a variety of training methods to promote the operating room nurses′humanistic quality by making good use of the morning shift time, the operating room nurses′humanistic care ability , theoretical knowledge , professional skills were improved significantly(P<0.05),and the operating rooms doctors, surgical patients′satisfaction of operating room nurses′service were improved ( P<0 .05 ) .Conclusion:Making good use of the morning shift time to improve the nurses′humanistic quality , at the same time , the nursing service quality and patients satisfaction were also improved .
6.EFFECTS OF SiNOMEMINE (SINO) ON HEMODYNAMICS IN ANESTHETIZED OPEN-CHEST DOGS
Fengyuan LI ; Xiangzhen KONG ; Shuzhong ZHAO ; Gengsheng ZHAO ;
Chinese Pharmacological Bulletin 1987;0(01):-
Sino 0.5 or 2 mg/kg iv reduced significantly heart rate ( HR), systolic blood pressure ( SBP ), diastolic blood pressure ( DBP ), left ventricular systolic pressure ( LVSP) , dP/dtmax, cardiac index ( CI ) and total peripheral resistance ( TPR ) . VCE- + dP/dtmax was unchanged. T value did't change in 0 .5mg/kg, but it elevated in 2 mg/kg.
7.Extracorporeal shock wave therapy for treatment of heel pain
Baolin LI ; Qingbo KONG ; Wei ZHAO ; Lixue MA ; Jiangang ZHAO
Chinese Journal of General Practitioners 2015;14(10):781-783
To explore the therapeutic efficacy of extracorporeal shock wave (ESW) for persistent heel pain.A total of 98 patients of persistent heel pain were randomly divided into ESW treatment and control groups (n =49 each).Treatment group had ESW while control group received infrared physical therapy.And their visual analogue scale (VAS) scores were assessed.After one course of treatment, VAS heel pain and function scores were (39.6 ± 6.2) and (25.1 ± 4.6) in ESW group versus (32.3 ± 6.5) and (17.4 ±7.2) in control group.And before treatment, (16.5 ±4.6) and (14.4 ±8.6), (16.1 ±4.7) and (14.6 ± 8.4) respectively.Heel pain significantly decreased with functional improvement (all P < 0.05).After one course, the effective rate was 65% (32/49) in treatment group.And the improvement rate of 31% (15/49) was better than control group [27% (13/49) and 63% (31/49)] (all P < 0.05).ESW treatment of persistent heel pain was more efficacious than physical therapy and it could be applied clinically.
8.Significance of cortactin expression in primary liver cancer
Gang ZHAO ; Hongyi ZHANG ; Li REN ; Yalin KONG ; Yu LI
Chinese Journal of Digestive Surgery 2010;09(6):444-446
Objective To investigate the significance of cortactin in primary liver cancer. Methods Fiftythree paraffin embedded primary liver cancer specimens were collected at General Hospital of Air Force of PLA from January 2002 to May 2008. The expression of cortactin was detected by immunohistochemistry, and the relationship between cortactin expression and clinicopathologic parameters was analyzed. All data were analyzed via Wilcoxon rank sum test and Spearman rank correlation analysis. Results There was a significant difference in cortactin expression among tumor capsule integrity, TNM staging, portal vein tumor thrombus and extrahepatic metastasis (u =2. 19, 3. 584, 2. 796, P < 0.05 ). There was a positive correlation between tumor invasion and cortactin expression ( r = 0. 5794, P < 0.05 ). Conclusions Overexpression of cortactin may be one of the factors enhancing the invasion of primary liver cancer. The level of cortactin expression can be used in evaluating the invasive potential of primary liver cancer.
9.Pre-treatment with radix astragali for myocardial cell apoptosis and its relative genes in rats with ischemic reperfusion
Shumin ZHAO ; Li HAN ; Lihui MA ; Jian ZHOU ; Xiangyu KONG
Chinese Journal of Tissue Engineering Research 2005;9(23):226-228
BACKGROUND: Radix astragali has the effect of protecting cells from damage in ischemic reperfusion, whether pre-treatment with radix astragali can protect myocardial eells from apoptosis in ischemic reperfusion ? OBJECTIVE: To investigate the effect of pre-treatment with radix astragali on apoptosis and its relative genes in rats with ischemic myocardial reperfusion DESIGN: A randomized and controlled trial taking Wistar rats as experimental subjects.SETTING: The Basic Medical Department of Chengde Medical College and the Geriatric Department of the Affiliated Hospital.MATERIALS: The experiment was completed in the Imunnohistochemical Laboratory of Basic Medical Institute in Chengde Medical College from February to December in 2004. A total of 30 healthy male Wistar rats were selected, and at random classified as groups of radix astragali pre-treated (radix astragali), ischemic reperfusion and psuedo-operated (control), 10 rats for each group.METHODS: Radix astragali injection was given peritonealy for rats in radix astragali pre-treated group before operation, and the equivalent normai saline was given for those in ischemic reperfusion and psuedo-operated groups. One week later, the model of ischemic reperfusion was set up. After operation the myocardia in marginal zone of ischemic reperfusion were sampled, and the myocardia of the corresponding zone were taken for control group. The method of terminal (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) was used for assay of myocardial apoptosis rate, and the ABC immunohistochemical method was used for assay of myocardial bcl-2 (inhibiting apoptosis gene) and bax (promoting apoptosis gene).MAIN OUTCOME MEASURES: Apoptosis rates, and expression of bcl2 and bax genes of myocardia RESULTS: ① Apoptosis rate of myocardial cells: The rate in radix astragali group was decreased compared with that in ischemic reperfusion group [ (14.06 ±9.97) %, (19.34±12.30) %, t = 1.863, P < 0.05].② Expression of bcl-2: There was no significant difference between radix astragali and ischemic reperfusion groups[(9.14±4.46) %, (8.99±4.54) %, P < 0.05].③ Expression of bax: The expression in radix astragali group was decreased compared with that in ischemic reperfusion group [(12.65 ±7.23)%,(18.12±7.92) %, t = 2.096, P < 0.05]CONCLUSION: Pre-treatment with radix astragali can down-regulate the expression of promoting apoptosis gene so as to reduce the rate of myocardial cell apoptosis, hence it can protect the myocardial cells in ischemic reperfusion.
10.Influencing factors in the refolding process of artificial molecular chaperone assisting chicken IL-18 recombination protein
Xinhua WANG ; Jingdong HU ; Na KONG ; Hongmei LI ; Hongkun ZHAO
Chinese Journal of Veterinary Science 2009;29(7):905-908
The recombinant plasmid of mChlL-18 prokaryotic expression was transformed into E.coli BL21(DE3) strain and then induced by IPTG at 37℃.After crushed and washed,the expressing inclusion bodies were thoroughly denatured with 6 mol/L guanidine hydrochloride.Then according to experiment design,the effects of rChlL-18 protein refolding yield at different densities were investigated by the systems of artificial chapercne at different densities.Experiment results indicate that there is a optimal condition on assiting rChIL-18 protein by using the artificial chaperone technique.The optimal condition can improve the refolding yield of rChIL-18 protein,and then the expressed product of fusion chicken IL-18 gene in E.coli has a relativity high bioactivity.