Objective To discuss the protective effect of intra-aortic balloon pump(IABP) on renal function in patients with chronic renal insufficiency undergoing cardiac operations.Methods From May 2010 to May 2012,17 patients with moderate renal insufficiency who underwent cardiac surgery using cardiac pulmonary bypass(CPB) were randomized to divide into IABP group and control group.IABP was inserted before the cardiac operation,the support was maintained perioperatively in IABP group.In control group the IABP was never used during the operation.The clinical parameters related to renal function including the output of urine,the serum creatinine levels were documented perioperatively.Results The serum creatinine levels were increased obviously post-operation in both groups.But the degree of increase was significantly smaller in IABP group.Conclusion To patients with moderate renal insufficiency undergoing CPB cardiac operations,perioperative application of IABP is beneficial to protect renal function and may help to improve the outcome.

Objective To investigate the relationship between the stenosis of clinically relevant artery or the characteristics of carotid plaques and frequent transient ischemic attacks(TIA).Methods Seventy-nine consecutive patients sufiered TIA attribute to carotid territory in the acute phase(within 7 days )who had been admitted to neurology department of Xuanwu Hospital from August 2005 to January 2007 were retrospectively analyzed.Patients with nonatherosclerotic vasculal disease were excluded.According to the times of TIA from the first attack to the day of hospitaliztion(within 7 days)patients were divided into two groups:those who had sparse TIA(onsets＜3 times),and those who had multiple TIA(onsets≥3 times).All patients underwent the examination of DSA.carotid ultrasound and transcranial doppler.The degree of stenosis of clinically relevant artery and the characteristics of carotid plaques were compared between the two groups.According to degree of stenosis of relevant artery,we defined as normal or＜50%stenosis.50%-69%stenosis.70%-99%stenosis or occlusion.According to the characteristics of carotid plaques we divided into stable or unstable plaques.Resuits Patients with TIA in carotid territory had more intracranial artery diseases.The middle cerebral artery was the most commonly involved artery(5 1.2%).the extracranial internal carotid artery was the next(37.2%).Multiple TIA were more likely to have a short duration of symptoms≤10 min than sparse TIA(x2=5.343,P=0.021).A significant stenosis of clinically relevant artery(≥50%)was demonstrated more frequently in the multiple TIA group(66.7%)than in the sparse TIA group(35.3%,x2=7.655,P=0.006).No significant correlation was observed between the multiple TIA and characteristics of carotid plaques in the focus side(x2=0.939,P=0.332).Conclusions Frequent TIA is significantly associated with a short duration of symptoms and≥50% stenosis of clinically relevant artery.Transient flow reduction by hemodynamic compromise may he an important mechanism of frequent TIA.

This paper describes the present situation for the lack of sense of life responsibility from health con-sciousness and life responsibilities, and from the school education, social environment, family influence and its own factors four aspects analyze the medical students lack of sense of responsibility at the root of life, and then on this basis put forward the corresponding countermeasures:schools should innovation course, pay attention to the clinical practice, to strengthen the construction of teachers′quality education, deepen the life value;the government should strengthen the administrative intervention; the network, the media should give full play to the guiding function;play a role of family environment influence and change the concept of family education;improve the ability of self-awareness and self-monitoring of frustration education and emotional education.

With the economic development of science and technology advance,medical model,as the total understanding of health and disease at a certain historical period,has undergone several different phases:spirtualism medical model,mechanistic medical model,Biological Medical Model and biological-psychological-social medical model.Under the background of biologic and psychogenic society medicine,the professional quality of contemporary doctor faces new requirements and challenges.This article discusses the necessity,importance and approaches of intensifying research on humanistic knowledge which adapts to the transformation of medical model.

Objective The aim of this study was to investigate the effects of the ERK5 pathway on bone morphogenetic protein?9(BMP9)?regu?lated osteogenic/odontogenic differentiation of immortalized stern cells from the apical papilla(iSCAP). Methods BMP9 was introduced into the iSCAP by using recombinant adenoviruses,and the P?ERK5 protein expression was measured via western blotting. Then,the osteogenic/odontoblas?tic changes were analyzed by alkaline phosphatase(ALP)staining and Alizarin red staining,and the expression of osteogenic/odontoblast?associat?ed genes,such as Runx2,OCN,OPN,and DMP1 was measured by RT?PCR. Results BMP9 could up?regulate the phosphorylation of ERK5 in iSCAP. After using BIX02189,which was an inhibitor of ERK5,the phosphorylation of ERK5;the activity of ALP;the expression of Runx2, OCN,OPN,and DMP1;and the calcium deposition were all significantly inhibited. Conclusion The ERK5 signaling pathway plays an important role in BMP9?regulated osteogenic/odontogenic differentiation of iSCAP.

Objective:To discuss the clinical efficacy of Shenghua Decoction combined with conventional western medicine therapy in treatment of polycystic ovarian syndrome with blood-insufficiency congealing-cold and blood-stasis syndrome. Methods:A total of 140 polycystic ovarian syndrome patients with blood-insufficiency congealing-cold and blood-stasis syndrome were selected from January 2018 to December 2019 in our hospitals, and were divided into observation group and control group according to the random indicator method, 70 cases in each group. The control group received ethinylestradiol and cyproterone acetate tablets treatment, and Shenghua Decoction was added based on the control group’s treatment in the observation group. Changes in the TCM syndrome score, modified Ferriman-Gallway (mF-G) of hirsutism, Rosenfield of acne, Testosterone (T), Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) levels detected by ELISA of two groups were observed. The adverse events were recorded and the clinical efficacy was evaluated. Results:The effective rate of the observation group was 88.6% (62/70), which was significantly higher than control group of 60.0% (42/70) ( χ2=14.957, P<0.001). After treatment, mF-G, Rosenfield and TCM Syndrome Scores in the observation group were significantly lower than those in the control group ( t=6.524, 3.111, 2.196, P<0.01 or P<0.05). After treatment, the levels of FSH [(5.16 ± 1.76) IU/L vs. (7.19 ± 1.06) IU/L, t=2.530], LH [(6.12 ± 1.88) IU/L vs. (8.03 ± 1.78) IU/L, t=2.403], T [(1.34 ± 0.32) μg/L vs. (1.80 ± 0.36) μg/L, t=7.080] in the observation group were significantly lower than those in the control group ( P<0.05 or P<0.01) Conclusion:The Shenghua Decoction showed beneficial effect for the patients with polycystic ovarian syndrome with blood-insufficiency congealing-cold and blood-stasis syndrome.

In order to know the effects of caloric stimulation on neuronal firing in medial vestibular nuclei (MVN) by middle ear irrigation, the middle ear was irrigated with ice (4 degrees C), hot (44 degrees C), and warm (37 degrees C) water, and the firing rate of MVN neuron was extracellularly recorded. The results showed that the firing rate of MVN neuron was changed by caloric stimulation, and the majority of MVN neurons showed excitation by irrigation with hot water and inhibition by ice water (type A). The neuronal firing was recovered immediately after the cessation of the stimulation. I It was concluded that the neuronal firing rate in MVN was changed by caloric stimulation in middle ear cavity. The response was different in various neurons.
Cold ; Ear, Middle ; Electrophysiology ; Endolymph/physiology ; Heat ; Irrigation ; Neurons/classification ; Neurons/physiology ; Rats, Wistar ; Vestibular Nerve/*physiology ; Vestibular Nuclei/*physiology

Based on the introduction of the concept and characteristics of the wearable medical devices,the paper elaborates the development situation of wearable medical devices at home and abroad,focuses on the statement of the functions of wearable medical devices in medical practice including achieving dynamic monitoring,providing medical diagnosis data,finding out the causes of diseases,achieving early treatment of diseases,promoting medical level,improving medical techniques,and relieving the situation of medical resources shortage of China,and meanwhile analyzes the problems of wearable medical devices and the healthcare industry.

Independent Institute is a model of exploration and innovation under a new situation of higher education mechanism and model and its students ideological and political work has its own particularity.This paper analyses the particularity of the ideological and political work of independent institute students,and discusses how to strengthen and improve the ideological and political work of independent institute students.

AIM and METHODS: In situ hybridization and image-analysis system were used to investigate the expression of NOSⅢ mRNA in cultured porcine pulmonary artery endothelial cells (PAEC) under normoxic or chronic hypoxic conditions. RESULTS: The expression of NOSⅢ mRNA were increased by 48%, 125%, 119% respectively in the 2nd, 4th, 6th subculture of normoxic PAEC after expouse to acute hypoxia for 12 hours while in chronic hypoxic group,the expression of Ⅲ NOS mRNA were increased by 92%, 245%, 565% separately. The increase was more apparent in chronic hypoxic group than in normoxic group and became more significant following the prolonging duration of hypoxia. CONCLUSION: Chronic hypoxia increased the expression of NOSⅢ gene in PAEC in response to acute hypoxia. Nitric oxide may play an important role in the decrease of hypoxic pulmonary vasoconstriction caused by chronic hypoxia.