1.Some variations of case-based techniques for the teaching of undergraduate pathology.
The Malaysian journal of pathology 2005;27(2):127-8
The challenges to the teaching of undergraduate pathology include adapting to the ever-evolving medical curriculum and the emergence of new teaching technologies. Nevertheless, pathology remains the crucial bridging medical discipline, with the pathology teacher playing an important role in consolidating the basic medical sciences and leading in the clinical disciplines. In this report, variations of case-based teaching of undergraduate pathology are discussed. These can be used in pathology lectures, tutorials and practical sessions, both traditional and computer-based. They contribute to the pathology teacher's repertoire of teaching tools and help add relevance and zest during class.
Pathology processes
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Teaching aspects
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TEACHERS
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Methodology
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seconds
2.Unusual presentation of adult xanthogranuloma: a case report.
Lixian Chris TAN ; Kong Bing TAN ; Chen Wee Derrick AW
Singapore medical journal 2014;55(2):e25-7
Xanthogranulomas are the most common form of non-Langerhans cell histiocytosis. Both adult and childhood forms have been described. Adult cutaneous forms can present as solitary or multiple yellowish, orange-red or tan-hued papules. Herein, we present the case of a 28-year-old Chinese man with a skin-coloured nodule on his left nasal ala that persisted for several months. While initial impression was that of a fibrous papule of the nose, the results of an excision biopsy showed histological features corresponding to xanthogranuloma. This case demonstrates the condition’s myriad of dermatological presentations, and adds to the differential diagnoses of a cutaneous lesion found in the head and neck region.
Adult
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Biopsy
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Diagnosis, Differential
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Granuloma
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diagnosis
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surgery
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Histiocytosis
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diagnosis
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Humans
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Male
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Skin
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pathology
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Skin Diseases
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diagnosis
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surgery
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Treatment Outcome
3.Left ventricular pseudoaneurysm: a case report and discussion on differential diagnoses.
Kong Bing Tan ; Siang Hui Lai ; Keng Poh Wee
The Malaysian journal of pathology 2003;25(2):135-8
Left ventricular pseudoaneurysm is a rare complication of myocardial infarction or cardiac trauma. We report a case of sudden death from rupture of such a lesion. Clinically, these lesions need to be distinguished from the other ventricular out-pouching lesions (true aneurysms and diverticula) because of their greater likelihood for rupture. Pathologically, apart from often being infarct-related, they are characterized by a narrow connection with the ventricular cavity and a fibrous outer wall that is devoid of myocardial tissue.
Lesion, NOS
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Left
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seconds
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Traumatic Rupture
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Case Report
7.Asymmetric left ventricular hypertrophy associated with morbid obesity mimicking familial hypertrophic cardiomyopathy.
Raymond Ching-Chiew WONG ; Kong Bing TAN
Singapore medical journal 2014;55(12):e201-4
Asymmetric septal hypertrophy with systolic anterior motion of the mitral valve is frequently a phenotypic, but not pathognomonic, expression of genetic hypertrophic cardiomyopathy (HCM) with or without obstruction. It can, however, be associated nonspecifically with other forms of increased left ventricular (LV) afterload. We herein report the case of a young man with obesity cardiomyopathy and heart failure who presented with asymmetric septal hypertrophy and marked LV hypertrophy, and endomyocardial biopsy ruled out genetic HCM.
Adult
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Cardiomyopathy, Hypertrophic, Familial
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Diagnosis, Differential
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Echocardiography
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Humans
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Hypertrophy, Left Ventricular
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complications
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diagnosis
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Male
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Obesity, Morbid
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complications
8.Large Forehead Nodule with Multiple Facial and Oral Papules.
May Mq LIAU ; Kong Bing TAN ; Victor Km LEE ; Sue Ann Je HO
Annals of the Academy of Medicine, Singapore 2016;45(10):481-483
Adult
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Facial Neoplasms
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diagnosis
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etiology
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pathology
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Fibroma
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diagnosis
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etiology
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pathology
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Forehead
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Hamartoma Syndrome, Multiple
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complications
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diagnosis
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pathology
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Humans
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Male
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Mouth Neoplasms
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diagnosis
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etiology
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Papilloma
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diagnosis
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etiology
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Skin Neoplasms
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diagnosis
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etiology
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pathology
9.Case Report of a Novel Association between Anti-p200Pemphigoid and Acquired Haemophilia A
Xuan Qi KOH ; Kong Bing TAN ; Enno SCHMIDT ; Detlef ZILLIKENS ; Nisha Suyien CHANDRAN
Annals of Dermatology 2023;35(1):61-65
Anti-p200 pemphigoid is an uncommon subepidermal autoimmune bullous disease that, unlike many other autoimmune bullous diseases, has not previously been associated with hematological diseases. The diagnosis of anti-p200 pemphigoid in a patient with congruent clinical features requires the demonstration of subepidermal blistering, with linear deposition of immunoglobulin (Ig) G and/or C3 at the dermoepidermal junction on direct immunofluorescence, and a floor-binding pattern on indirect immunofluorescence. In addition, the detection of antibodies against p200 antigen via immunoblotting is ideal but not readily accessible in many facilities, leading to a potential under-recognition and under-diagnosis of this condition. In this case report, we describe a 53-year-old gentleman with recently diagnosed acquired hemophilia A who developed a concurrent vesiculobullous eruption and was evaluated to have anti-p200 pemphigoid. Both of his conditions were controlled with immunosuppression via prednisolone and cyclophosphamide. While we acknowledge the contemporaneous occurrence of both diseases in this patient may be a mere coincidence, it is important to recognize the possibility of this association given the potential clinical significance. Whether the activity of one disease parallels the other will require further evaluation.
10.Studies on constituents of Oldenlandia diffusa.
Ying-Jun ZHOU ; Kong-Song WU ; Guang-Yao ZENG ; Jian-Bing TAN ; Kang-Ping XU ; Fu-Shuang LI ; Gui-Shan TAN
China Journal of Chinese Materia Medica 2007;32(7):590-593
OBJECTIVETo investigate the chemical constituents of Oldenlandia diffusa.
METHODThe column chromatography with polyamide Sephadex LH -20, silica gel as packing materials and HPLC, were used to separate and purify the chemical components. The structures were elucidated on the basis of physicochemical properties and spectral data.
RESULTNine compounds were isolated and identified as 2, 6-dihydroxy-1-methoxy-3-methylanthraquinone (1), 2-hydroxy-1-methoxy-3-methylanthraquinone (2), 2-hydroxy-3-methylanthraquinone (3), quercetin-3-O-[2-O-(6-O-E-sinapoyl)-beta-D-glucopyranosyl]-beta-glucopyranoside (4), quercetin-3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-glucopyranoside (5), kaempferol-3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-galactopyranoside (6), quercetin-3-O-(2-O-beta-D-glucop-yranosyl)-beta-D-glucopyranoside (7), rutin (8) and quercertin (9).
CONCLUSIONCompounds 1 and 8 were obtained from this plant for the first time, and compound 1 was a new compound.
Anthraquinones ; chemistry ; isolation & purification ; Molecular Conformation ; Molecular Structure ; Oldenlandia ; chemistry ; Plants, Medicinal ; chemistry ; Quercetin ; chemistry ; isolation & purification ; Rutin ; chemistry ; isolation & purification