No abstract available.
Animals ; Mice* ; Valproic Acid*

The goal of therapy of epileptic children is to control of seizures with minimal side effects of antiepileptic drug (AED). The relationship between side effects, serum levels and doses of AED were examined prospectively in 72 epileptic children who received monotherapy with phenobarbital, phenytoin, valproate, or carbamazepine for 6 to 26 months. Our results were as follows: 1) Side effects were observed in 59.7% of all patients; in decreasing order, behavioral (41.6%)>digestive (25.0%)>others (22.2%)>neurologic (11.1%). 2) The most common side effects in children treated with phenobarbital (PB) was behavioral (54.2%); these included hyperactivity, drowsiness, sleeping in decreasing order and there was significant relationship between drowsiness and serum level of PB(P<0.05). 3) Common side effects in patients receing carbamazepine (CBZ) were behavioral (52.0%) and digestive (52.2%); behavioral disorders included drowsiness and sleeping which showed significance with dosage of CBZ (P<0.01), digestive disorders were abdominal pain which showed significance, with dosage of CBZ (P<0.05) and weight gain. Other side effects were dizziness, headache, diplopia, tremor pallor, durg eruption, alopecia, aggravated acne etc. 4) The most common side effect in children treated with valproate (VPA) was pallor which showed significance with dosage of VPA (P<0.05). Abdominal pain had<0.05 significance with serum level of VPA, and Other side effects were anemia and weight gain. 5) In 83.3% of all patients, they had no side effects or could tolerate mild side effects. But in 12.5% of patients, the side effects disappeared when dosages were reduced, and AED had to be withdrawn in only 4.2% of patients.
Abdominal Pain ; Acne Vulgaris ; Alopecia ; Anemia ; Anticonvulsants* ; Carbamazepine ; Child* ; Diplopia ; Dizziness ; Headache ; Humans ; Pallor ; Phenobarbital ; Phenytoin ; Prospective Studies ; Seizures ; Sleep Stages ; Tremor ; Valproic Acid ; Weight Gain

No abstract available.
Child* ; Colon* ; Humans

No abstract available.
Korea* ; Measles* ; Vaccination*

No abstract available.
Respiratory Syncytial Virus Infections* ; Respiratory Syncytial Viruses*

The third complementarity determining region (CDR3) of the immunoglobulin (Ig) kappa () chain is known to be located at the center of antigen binding groove and critical for antibody specificity. Ig chain has been characterized by limited junctional diversity due to the absence of N-region addition resulting in relative conservation of CDR3 lengths with 9 or 10 amino acids. CDR3 region of 11 amino acids is only possible with N-region addition. Recently, x transcripts with 11 amino acids CDR3 was found to be expressed in normal individuals, and in autoimrnune disease such as rheumatoid arthritis, the fraction of 11 amino acids CDR3 of humkv325-derived chains was overexpressed compared to conventional adult peripheral B cells. However, the significance of this bias is difficult to interpret without a clear understanding of normal repertoire of CDR3 length during development. The purpose of this study is to determine whether developmental regulation of CDR3 amino acids codon lengths exists in chains expressed in the fetal liver, cord blood, and adult peripheral blood lymphocytes (PBL). Lymphocytes were seperated from fetal liver, cord blood and adult PBL and cDNA was generated from extracted mRNA. PCR-based CDR3 finger- printing assay was performed with VI-IV family specific primers. CDR3 length diversity of Ig x chain increases as the development proceeds. The length diversity most frequently occured in Vlll family derived transcripts including 11 amino acids CDR3. transcripts with 11 amino acids CDR3 were consitently expressed in both fetal and adult Ig repertoire. These results support the hypothesis that v chain CDR3 length is developmentally regulated and implicates the diversity of antigen-antibody specificity generation.
Adult ; Amino Acids ; Antibody Specificity ; Arthritis, Rheumatoid ; B-Lymphocytes ; Bias (Epidemiology) ; Codon ; Complementarity Determining Regions ; DNA, Complementary ; Fetal Blood ; Humans* ; Immunoglobulin kappa-Chains* ; Immunoglobulins* ; Liver ; Lymphocytes ; RNA, Messenger ; Sensitivity and Specificity

PURPOSE: The incidence of genitourinary tuberculosis(tbc) has consistently declined as results of effective chemotherapy and health care. But it still has significant associated morbidity. The pathogenesis of prostatic and epididymal tbc remains obscure. To assess the progress of tuberculous infection in sex accessory organs including prostate, epididymis and testis, prospective clinical study was performed. MATERIALS AND METHODS: Of the 58 male patients with genitourinary tbc during a 8-year period(1989-1996), 23 patients (39.7%) had tuberculosis in sex accessory organs. Thirty patients who demonstrated tuberculosis in at least one organ amomg prostate, epididymis, testis and bladder were evaluated. The conclusive diagnosis was made on the basis of isolation of Mycobacterium tuberculosis, histopathology. A patients with organ confined tbc was considered to be caused by metastatic spread of infection. RESULTS: In 12(40%) of 30 patients tubercle bacilli were detected in urine. 14(87.5%) of the 16 patients with tuberculous epididymitis and 10(76.9%) of the 13 patients with tuberculous prostatitis were considered to have an infection extended through the metastatic spread. Three(25%) patients had tuberculous cystitis directly extended from the tuberculous prostatitis. All three tuberculous orchitis were secondary to the tuberculous epididymitis. CONCLUSIONS: The results suggest that the route of infection of tuberculosis in the prostate and the epididymis are mainly through the hematogenous spread and direct extension of infection is likely deveploped by descending spread.
Cystitis ; Delivery of Health Care ; Diagnosis ; Drug Therapy ; Epididymis ; Epididymitis ; Humans ; Incidence ; Male ; Mycobacterium tuberculosis ; Orchitis ; Prospective Studies ; Prostate ; Prostatitis ; Testis ; Tuberculosis* ; Urinary Bladder

Number of germ cells in the seminiferous epithelium was analyzed quantitatively in testicular biopsy specimens of 23 patients without ductal obstruction and of 4 patients with ductal obstruction. Roth number of mature spermatids within each cross-section of seminiferous tubule and number of atrophic tubule were counted in biopsy specimens. Results were expressed as cell number of mature spermatids per seminiferous tubule and percentage of atrophic tubules. A significant correlation was demonstrated between sperm density and mature spermatid counts. Patients with sperm counts of less than 40 x l0(6)/ml had mature spermatids counts of less than 25 per seminiferous tubule. Coefficients of correlation between mature spermatid count and percentage of atrophic tubules were higher than those of correlation between sperm counts and percentage of atrophic tubules. In asoospermrc patients with epididymal obstruction, sperm count after corrective surgery could be predicted correctly by this quantitative analysis technique of testicular biopsy specimens and partial obstruction of anastomotic site of seminal tract could be proved in oligozoospermic patients after corrective surgery.
Biopsy ; Cell Count ; Germ Cells ; Humans* ; Seminiferous Epithelium* ; Seminiferous Tubules ; Sperm Count ; Spermatids ; Spermatozoa ; Testis*

A discrepancy between patency and pregnancy rates persists even if a surgical success rate of vasovasostomy, improved. A sperm granuloma has been considered that it has relation to improvement of quality of sperm by decompression of intravasal pressure. During the period from 1981 to 1983, a total of 160 vasovasostomies were performed. An age of the patient ranged from 24 to 65 with the mean of 36.5. Duration of obstruction ranged from 5 months to 20 years with the mean of 4.2 years. Viable sperms more than 10 x 1,000,000/ml appeared in 145 out of the 160 patients (90.6%) , and pregnancy occurred in 98 out of the 160 patients (61.2%) following the vasovasostomy The sperm granuloma was found in 50% of 160 vasectomized patients. Forty-eight percent of patients whose patency were restored had sperm granuloma. Fifty percent of patients who impregnated their wives had sperm granuloma. There was statistically no significant difference in both patency and pregnancy rates between patients with and without sperm granuloma. But sperm months at 6 months post operatively was found to be higher in patients with sperm granuloma than without sperm granuloma (p<0.05).
Decompression ; Granuloma* ; Humans ; Infertility ; Pregnancy ; Pregnancy Rate ; Spermatozoa* ; Spouses ; Vasovasostomy*

No abstract available.
Tobacco Smoke Pollution*