1.A Clinical Study of Acupuncture Therapy for Lumbar Spinal Canal Stenosis.
Daichi KASUYA ; Fujio TAKEUCHI ; Kazuhiko YAMAMOTO ; Koji ITO ; Tomomi SAKAI
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 1999;62(4):201-206
We executed an acupuncture therapy to 62 lumbar spinal canal stenosis cases who were diagnosed by CT, MRI photo state and clinical symptom and examined the result.
The 36 men and 26 women in this study had a mean age of 67.3 years.
An acupuncture was executed by aiming to give an effect to the soft tissues and a blood circulation around the area where the stenosis was recognized then pierced facet joint closely and deeply and gave an electric acupuncture stimulus.
14 cases were very good and 17 cases had good results according to the JOA score. No cases worsened.
We concluded an acupuncture treatment was effective for treating lumbar spinal canal stenosis.
2.Revision of Undergraduate Medical Education in United Kingdom. Recommendation of General Medical Council and the Curriculum of the University of Leicester.
Atsushi HIRAIDE ; Koji YAMAMOTO ; Akinori KASAHARA ; Ikuto YOSHIYA
Medical Education 1999;30(2):87-91
We have reviewed the Recommendations on Undergraduate Medical Education published by the General Medical Council (GMC) of the United Kingdom in 1993, and have visited the University of Leicester to see how they have revised their medical course to take account of the GMC's recommendations. The aim of the GMC's recommendations is to promote a culture of self directed learning which will be of value to the future medical practitioners in their postgraduate careers. To achieve this the GMC recommends a reduction in the burden of factual information delivered to the student while promoting learning through curiosity and the exploration of knowledge. The students are given an integrated view of clinical and basic scientific disciplines. The University of Leicester has reorganised its medical teaching around modules relating to body function rather than the traditional disciplines, with contributions being made by clinicians and basic scientists in the same module. The new course places great emphasis on carefully guided and structured self directed study and a reduced number of lectures. Clinical skills are introduced early in the curriculum, while a deeper understanding of selected scientific disciplines are achieved by a series of special study modules where the students undertake supervised scientific research.
3.Delayed Hemothorax After Conservative Treatment of Sternal Fracture
Naoki Yamamoto ; Masahiro Sakakibara ; Maki Murakami ; Koji Sakaguchi
General Medicine 2011;12(2):85-88
Delayed hemothorax following blunt chest trauma is classified as a late presentation of hemothorax after a nearly normal chest X-ray on admission. Here, we present a case of delayed hemothorax 5 days after blunt chest trauma with ribs and sternal fracture.
4.The Effect of Human Placental Extracts in Suppressing Tumor Cell and Preventing Normal Cell Damage
Eiichi HIRANO ; Katsunori YAMAMOTO ; Koji TAMADA ; Taiichi KAKU ; Tetsuo MORINAGA
Japanese Journal of Complementary and Alternative Medicine 2015;12(2):65-71
Objectives: To analyze the effect of human placental extracts (HPEx) on hepatocellular carcinoma cells in vitro. Methods: The hepatocellular carcinoma cell lines, namely, HLE and Huh-7, were used. The cells were subjected to a growth assay using the formazan dye method; the effect of combination treatment with sorafenib and HPEx was also assessed. The preventing normal cell damage effect of HPEx was analyzed by virtual therapy where possible; the experimental protocol was constructed on the basis of pre- and post-sorafenib treatment data. Cytotoxicity was measured by lactate dehydrogenase (LDH) assay. Results: HPEx caused significant dose-dependent suppression in the growth of HLE and Huh-7 cells. These tumor cells were significantly suppressed by combination treatment with HPEx and sorafenib. In addition, HPEx potentiated sorafenib sensitivity against tumor cells, and significantly prevented sorafenib-induced cytotoxicity in primary cultured rat hepatocytes under all designed experimental conditions. Specifically, pre-treatment with HPEx had a greater effect than post-treatment with HPEx. Conclusion: HPEx suppresses tumor cell growth, potentiates sorafenib efficacy, and has a preventing normal cell damage effect; this triple functionality of HPEx makes it a useful agent for liver cancer therapy.
5.A Case of Drug-Induced Hypersensitivity Syndrome Complicated with Acute Pancreatitis
Hideo TAKENOSHITA ; Toshiyuki YAMAMOTO ; Mikiko TOHYAMA ; Koji HASHIMOTO
Journal of the Japanese Association of Rural Medicine 2009;58(4):476-482
A 59-year-old female was started on oral carbamazepine for her psychological disorder on April 21 2004. Four weeks later, she developed generalized erythemas on the trunk and extremities, and ran a high fever of 38°C. A physical examination showed erythroderma, and laboratory examination revealed liver dysfunction and hypereosinophilia. Three days after admission, a number of small pustules emerged on the erythrodermic backgrounds. The skin lesions were improved by the withdrawal of carbamazepine and systemic prednisolone (50mg per day). However, acute pancreatitis was also developed during the course. HHV-6 IgG was increased up to x1280 on June 17. Also, HHV-6 DNA was detected with two peaks during the therapy. DLST with carbamazepine showed a high titer of stimulation index. This case was unique in the acute generalized exanthematous pustulosis (AGEP)-like clinical appearance and the development of acute pancreatitis. HHV-6 DNA was increased with double peaks, which might suggest a “re-reactivation” of HHV-6 by carbamazepine.
6.THE RELATIONSHIP BETWEEN THE RUNNING ECONOMY AND THE HOPPING ECONOMY IN THE LONG DISTANCE RUNNER
SEIJI TAKEDA ; YASUMITSU ISHII ; MASAYOSHI YAMAMOTO ; KOJI ZUSHI
Japanese Journal of Physical Fitness and Sports Medicine 2010;59(1):107-118
Running economy is an important factor in determining a performance of a long distance running. The purpose of this study was to examine the relationship between the running economy and the submaximal hopping economy. Twelve long-distance runners performed a submaximal repeated hopping exercise on a force platform at a frequency of 2.2Hz and the maximum five-repeated rebound jumping (5RJ). Jumping height, contact time, maximum ground reaction force and oxygen intake were recorded during submaximal repeated hopping exercise. In addition, they performed the submaximal running for a distance of 3200m on an outdoor 400m track. Oxygen intake was recorded during the submaximal running. Then running economy (RE = V/VO2) was calculated by using oxygen intake (VO2) and running speeds (V). Hopping economy (HE = h/VO2) was calculated by using oxygen intake (VO2) and average jumping height (h). As a result of this study, we confirmed that a submaximal repeated hopping exercise performed for a ten-minute period was an aerobic exercise and a steady-state exercise. There was a significant positive correlation between RE and HE (r = 0.805, p<0.01). These results suggest that hopping economy is an important factor in running economy. On the other hand, we did not find a significant correlation between HE and 5RJ. Furthermore, between RE and RJ index of the submaximal hopping exercise, a significant positive correlation was found (r = 0.735, p<0.01). Therefore, RE seems to be connected with the Stretch-shortening cycle (SSC) function of the legs. We conclude that the SSC ability of a long distance runner can be evaluated appropriately by using the submaximal repeated hopping exercise of this study.
7.How to Innovate Initial Postgraduate Clinical Training
Junji OHTAKI ; Haku ISHIDA ; Koji SENSAKI ; Ritsuko YAMAMOTO ; Shuji MIYAKE
Medical Education 1988;19(6):418-418,423
8.Use of Diffusion-Weighted Imaging for Cerebral Infarctions in Kainan General Hospital.
Koji MIZUTANI ; Tomotaka SUMIDA ; Shinichi UMEDA ; Naoto YAMAMOTO ; Toshihiko TANASAWA ; Koji HATTORI ; Tadao SUGATA ; Isao TANIMOTO
Journal of the Japanese Association of Rural Medicine 1996;45(1):28-32
Many reports say that DWI (diffusion-weighted-image) is very useful for the diagnosis of cerebral infarction, especially in the acute phase, but it is difficult to have a fine image because DWI is very sensitive to artifacts caused by the “body-move” of the patient.
About the degree of MPG (motion probing gradient), criteria are yet to be established. Many persons try in their own way. With MPG5, the intensity of CSF and that of the focal lesion are almost equal, so that it is difficult to distinguish infarcts from adjacent ventricles.
The stronger the degree of MPG is, the more artifacts or noises we get, We recommend MPG6 or 7 in the right-left direction.
9.A Surgically Treated Case of Abdominal Aortic Aneurysm Associated with Melioidosis.
Hiroshi Sugimura ; Koji Watanabe ; Shuichiro Sugimura ; Tadashi Iriyama ; Yoshinobu Hattori ; Koji Negi ; Mitsuru Yamashita ; Ryo Hoshino ; Toru Yamamoto ; Yoshitsugu Iinuma
Japanese Journal of Cardiovascular Surgery 1998;27(4):237-240
A 58-year-old man was admitted for pneumonia after several business trips to Thailand, Vietnam, and Malaysia. Despite resolution of pneumonia on chest X-ray, high fever persisted. CT scan revealed a juxtarenal, atypical-shaped abdominal aortic aneurysm of 4.5cm in size, and this was thought to be the cause of persisting fever. After prolonged antibiotic treatment, surgical resection and prosthetic tube replacement of the aneurysm was performed. The aneurysm was a pseudoaneurysm, and histological examination showed chronic inflammation with no atherosclerotic change. It was thought to be of mycotic origin. On the 12th day after operation, he became febrile, and an arterial blood culture yielded Burkholderia pseudomallei. Antibiotics chosen according to sensitivity tests, were given. He was finally discharged with no exidence of persisting infection, on the 55th day after operation.
10.Experience of Clinical Practice During the Student Era at Osaka University Medical School.
Koji YAMAMOTO ; Atsushi HIRAIDE ; Naruya TOMITA ; Shinji NEGORO ; Akihiko ITO ; Akinori KASAHARA ; Ikuto YOSHIYA
Medical Education 2000;31(1):17-21
To clarify the experience in clinical practice of students at Osaka University Medical School, a questionnaire survey was performed according to the International Classification of Primary Care. More than half of the students had observed only 6 of the 23 reasons for seeking primary care such as headache and hypertension but had not experienced 17 of the 23 reasons, such as cough and abdominal pain. Most students had observed malignancy and chronic diseases, but more than half had only knowledge of 54 of 105 diseases such as appendicitis. In conclusion, medical students' experiences in clinical practice are not well balanced.