1.Combined Clozapine and Electroconvulsive Therapy in a Japanese Schizophrenia Patient: A Case Report.
Yuta YOSHINO ; Yuki OZAKI ; Koichiro KAWASOE ; Shinichiro OCHI ; Takanori NIIYA ; Naomi SONOBE ; Teruhisa MATSUMOTO ; Shu Ichi UENO
Clinical Psychopharmacology and Neuroscience 2014;12(2):160-162
Clozapine is well-known for successful use in schizophrenic patients treatment resistant to other antipsychotics. However, even with clozapine, 25% of schizophrenic patients are not in remission. Recently, as adjunctive treatment with clozapine, electroconvulsive therapy has been reported to be an effective and safe adjunctive treatment. We report a Japanese schizophrenic woman who was not in remission with clozapine alone but with both clozapine and electroconvulsive therapy.
Antipsychotic Agents
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Asian Continental Ancestry Group*
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Clozapine*
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Electroconvulsive Therapy*
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Female
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Humans
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Lithium
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Schizophrenia*
2.Efficacy and Safety of Trastuzumab Deruxtecan and Nivolumab as Third- or Later-Line Treatment for HER2-Positive Advanced Gastric Cancer: A SingleInstitution Retrospective Study
Keitaro SHIMOZAKI ; Izuma NAKAYAMA ; Daisuke TAKAHARI ; Kengo NAGASHIMA ; Koichiro YOSHINO ; Koshiro FUKUDA ; Shota FUKUOKA ; Hiroki OSUMI ; Mariko OGURA ; Takeru WAKATSUKI ; Akira OOKI ; Eiji SHINOZAKI ; Keisho CHIN ; Kensei YAMAGUCHI
Journal of Gastric Cancer 2023;23(4):609-621
Purpose:
Determination of optimal treatment strategies for HER2-positive advanced gastric cancer (AGC) in randomized trials is necessary despite difficulties in direct comparison between trastuzumab deruxtecan (T-DXd) and nivolumab as third or later-line treatments.
Materials and Methods:
This single-institution, retrospective study aimed to describe the real-world efficacy and safety of T-DXd and nivolumab as ≥ third line treatments for HER2-positive AGC between March 2016 and May 2022. Overall, 58 patients (median age, 64 years;69% male) were eligible for the study (T-DXd group, n=20; nivolumab group, n=38).
Results:
Most patients exhibited a HER2 3+ status (72%) and presented metastatic disease at diagnosis (66%). The response rates of 41 patients with measurable lesions in the T-DXd and nivolumab groups were 50% and 15%, respectively. The T-DXd and nivolumab groups had a median progression-free survival of 4.8 months (95% confidence interval [CI], 3.3, 7.0) and 2.3 months (95% CI, 1.5, 3.5), median overall survival (OS) of 10.8 months (95% CI, 6.9, 23.8) and 11.7 months (95% CI, 7.6, 17.1), and grade 3 or greater adverse event rates of 50% and 2%, respectively. Overall, 64% patients received subsequent treatment. Among 23 patients who received both regimens, the T-DXd–nivolumab and nivolumab–T-DXd groups had a median OS of 14.0 months (95% CI, 5.0, not reached) and 19.3 months (95% CI, 9.5, 25.1), respectively.
Conclusions
T-DXd and nivolumab showed distinct efficacy and toxicity profiles as ≥ third line treatments for HER2-positive AGC. Considering the distinct features of each regimen, they may help clinicians personalize optimal treatment approaches for these patients.